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protein function

10362 relationships annotated with this phrase. Showing first 500 of 10362.
Source entity Relationship Target entity Species
Fn3 domain in GH3 β-xylosidase might be involved in anchoring enzyme on large polymeric substrates and thermostability
RhNAC100-Enhanced GFP fusion protein localization to nucleus supports theory that RhNAC100 is a transcription factor
six convergent shifts in FT were located in critical sites that may influence enzyme function
N. benthamiana ortholog of (PBS1, AT5G13160) (PGSC0003DMP400014933) does not substitute for Arabidopsis (PBS1, AT5G13160) when conducting transient expression assays Nicotiana benthamiana
Slr1064 needs to bind to membrane to perform its function Synechocystis
artificial excision of (ATSYP132, SYP132, AT5G08080) (DDP1, PTM, AT5G35210) region severely interfered with normal (ATSYP132, SYP132, AT5G08080) activity Oryza sativa
distinct or overlapping patterns of gene expression and subcellular localization could be further investigated to explore functional divergence or redundancy of MCTP members Arabidopsis thaliana
NRC-like helper NLRs if form complex with Rx1, might be candidates for which sequestering in nonfunctional complex would affect resistance
expression of this mutant does not affect other resistance proteins Arabidopsis thaliana
glycine to charged residue substitution in BUZZ catalytic domain might affect catalytic properties of BUZZ Brachypodium distachyon
AtRPL10B expressed under (RPL10, RPL10A, SAC52, uL16z, AT1G14320) promoter showed complementation with slower growth rate than (GAL1, GALK, AT3G06580) promoter Saccharomyces cerevisiae
function of RhNAC100m supposed to be identical to RhNAC100
rhd3-1 point mutant exerts dominant-negative effect on RHD3-like (RL) proteins Arabidopsis thaliana
AtRPL10B-GFP fusion protein is functional in Arabidopsis Arabidopsis thaliana
ZmRCAα protein contains two conserved ATP-binding domains Zea mays
intron-containing mRNAs for OsNF-YA4 and OsWRKY55 exert function similar to protein encoded by CS transcript
mutated versions of (ALMT12, ATALMT12, QUAC1, AT4G17970) ALMT13 and ALMT14 are nonfunctional in triple mutants Arabidopsis thaliana
residual levels of mutated (GOM8, RHD3, AT3G13870) in -1 may have dominant-negative effect on Arabidopsis development Arabidopsis thaliana
PnTGS1 proteins complementation in yeast ∆tgs1 mutants expressing full-length and truncated PnTGS1 proteins Paspalum notatum
artificial excision of (ATSYP132, SYP132, AT5G08080) (DDP1, PTM, AT5G35210) region has dominant-negative effect Oryza sativa
Arabidopsis (RPL10, RPL10A, SAC52, uL16z, AT1G14320) proteins are functionally equivalent to Saccharomyces cerevisiae (RPL10, RPL10A, SAC52, uL16z, AT1G14320) Arabidopsis thaliana; Saccharomyces cerevisiae
RALPH effector BEC1054 in Bgh was shown to have ribosomal RNA-binding capabilities Blumeria graminis
C terminus of SKRP is critical for function of SKRP Arabidopsis thaliana
UspA proteins in plants little functional information on prior to this study Arabidopsis thaliana
G-to-A mutation at codon 246 in (AtSAMS3, MAT4, MTO3, SAMS3, AT3G17390) is different from (AtSAMS3, MAT4, MTO3, SAMS3, AT3G17390) mutation in ATP binding site Arabidopsis thaliana
(OHP, OHP1, PDE335, AT5G02120) and (OHP2, AT1G34000) do not functionally complement each other Arabidopsis thaliana
loss-of-function mutants of Arabidopsis (RPS2, uS2C, ATCG00160) with alterations in CC domain suppress activity of wild-type (RPS2, uS2C, ATCG00160) expressed in same Arabidopsis background Arabidopsis thaliana
weaker activation observed for LG3 suggests more divergent binding properties Nicotiana benthamiana
coexpression of CC, CC-NB-ARC, NB-ARC, or LRR with full-length Rx1 leads to dominant negative suppression of Rx1-mediated resistance and cell death
LRR domain is important for LRX function Arabidopsis thaliana
truncated Rx1 protein lacking CC domain was functionally complemented by coexpressed full-length Gpa2 protein
activity of chimeric Mi constructs was suppressed only by N-terminal domain originating from same Mi protein as LRR in chimeric construct Solanum lycopersicum
PrxQA localization pattern in stromules suggests unexpected function of PrxQA in stromules Physcomitrella patens
G-to-A mutation at codon 246 in (AtSAMS3, MAT4, MTO3, SAMS3, AT3G17390) occurs in conserved amino acid involved in binding Met Arabidopsis thaliana; Homo sapiens
RanGAP2-bound and free pools of Rx1 in cell differ in activity or stability
Arabidopsis homologs of mitochondrial GrpE co-chaperone and (HSP70, AT4G16660) apparent co-expression suggests similar functional relationship Arabidopsis thaliana
functions of mucin-like proteins in insects are largely unknown
SNP −85A/G and 4.5-kb insertion substantially affect functions of BrpHL1b in Bre Brassica rapa
much smaller segments of CC of Rx1 are still functional in trans with NB-ARC-LRR
kinase surface domain is not involved in ATP binding Hordeum vulgare
similar autoactive mutant of resistance protein Rpi-blb1 from Solanum bulbocastanum is not suppressed by LRR of Prf Solanum bulbocastanum
IDS1 protein amount increases IDS1 enzyme activity Picea glauca
NB domain when tested for dominant negative activity, did not have suppressive effect on Rx1-mediated resistance
not all Pm3 variants that interact have suppressive effect Triticum aestivum
key individual residues in these channels determine important properties of channels
(PCK2, PEPCK, AT5G65690) has pleiotropic activity Arabidopsis thaliana
these proteins may have some function independent of cytokinin Oryza sativa
self-association is required for functioning of several other CC- and TIR-NB-LRR proteins
mutation in 12th repeat of LRR of (EMB3113, PRPS5, RPS5, SCA1, uS5c, AT2G33800) inactivates (EMB3113, PRPS5, RPS5, SCA1, uS5c, AT2G33800) Arabidopsis thaliana
modifications occurring in the ER are required for functionality of signal proteins Arabidopsis thaliana
Substitution E572K in (EMB3113, PRPS5, RPS5, SCA1, uS5c, AT2G33800) surprisingly also suppresses subset of other NB-LRRs in Arabidopsis not limited to CC-NB-LRR proteins Arabidopsis thaliana
insertion in the D-loop of NBD1 might interfere with nucleotide binding Zea mays
CC-NB-ARC of Pm3 proteins in contrast to what we observe for Rx1 Triticum aestivum
dominant negative activities can be informative on functional mechanisms of protein
residues in helix 4 of CC required for interaction with (RANGAP2, AT5G19320) are also required for suppressive effect of CC
FLS2-epitope fusions have been assumed to be functional
(GAUT13, AT3G01040) and (GAUT14, AT5G15470) share overlapping function with (GAUT12, IRX8, LGT6, AT5G54690)
(AtGRF7, GRF7, AT5G53660) and (AtGRF9, GRF9, AT2G45480) may be equivalent to other GRFs, at least at the protein level Arabidopsis thaliana
(ATEXO70H4, EXO70H4, AT3G09520) function is highly specific (ATEXO70H4, EXO70H4, AT3G09520) Arabidopsis thaliana
(ATCBL2, CBL2, SCaBP1, AT5G55990) rely on PAT10 for functionality
Citrine insertion does not obstruct protein activity Arabidopsis thaliana
helper NLRs might have taken over role in signaling from Rx1 that autoactive CC domains of MLA-like proteins possess
Bs2 shows similar dependence on NRCs as Rx1
different C-terminal domains of different TOLs contribute to distinct localization and function
(PP7L, AT5G10900) mutant phenotype may be due to ectopic activity of (MAIL3, AT1G48120) Arabidopsis thaliana
CaDeSI2 localization in nucleus and cytoplasm indicates CaDeSI2 plays roles in both nuclear and cytoplasmic compartments Nicotiana benthamiana
differentially abundant proteins were enriched in Gene Ontology (GO) term Intrinsic Component of Membrane Oryza sativa
three conserved histidine motifs in membrane-bound FA desaturases are required for catalytic activity
difference in subcellular localization of (ATBPM1, BPM1, AT5G19000) and (ATCUL3, ATCUL3A, CUL3, CUL3A, AT1G26830) imply potentially unrelated functions of (ATBPM1, BPM1, AT5G19000) when deprived of (ATCUL3, ATCUL3A, CUL3, CUL3A, AT1G26830) Arabidopsis thaliana
(VUP1, AT3G21710) and its close homologs may act as regulatory proteins Arabidopsis thaliana
plant lipoate-protein ligases lacking C-terminal domain are not bifunctional
SNP in fgt2-1 causes amino acid exchange from leucine to phenylalanine at position 44 of (APD9, FGT2, AT5G66080) /P2C79 protein Arabidopsis thaliana
point mutation Leu51Arg in AQP5 converted AQP5 from a water channel to an anion channel
absence of NLS2 in GmPRR3b H6 may reduce but not abolish biological activity of GmPRR3b H6 Glycine max
at least four or more transmembrane domains are required for functional transport protein
site-directed mutagenesis studies indicate indel does not account for lack of catalytic activity Arabidopsis thaliana
SPA family members ( (SPA1, AT2G46340) to (SPA4, AT1G53090) ) exhibit partially overlapping functions and differential pattern of expression
GmPRR3b H6 has moderate activity in comparison with GmPRR3b H4 Glycine max
substitution of (CLE7, AT2G31082) signal peptide with rice signal peptide attenuated overexpression phenotypes of (CLE7, AT2G31082) Arabidopsis thaliana
Gnd protein might have moonlight function Synechocystis
proteins carry out most biological activities
disrupting either the ubiquitination of, or ubiquitin binding by, (TOL6, AT2G38410) affected localization and function of the protein
missing amino acid residue 125A is dispensable for (HEMG2, MEE61, PPO2, AT5G14220) function Hordeum vulgare
Mi-ASP2 may have an additional role in plant cell
overexpression of AFP fusion proteins might affect native function of the fusion protein
dimer is structure basis for nucleating and bundling activity Arabidopsis thaliana
S328 is necessary for (ATEXO70A1, EXO70A1, AT5G03540) function Arabidopsis thaliana
OFP3-Flag fusion proteins are functional in plants Oryza sativa
(AtCLE6, CLE6, AT2G31085) and (CLE7, AT2G31082) proteins with substituted signal peptides attenuated ability to substitute for (AtCLV3, CLV3, AT2G27250) Arabidopsis thaliana
TOL6:ubq I44A:Ven construct completely restored the ability to function like wild-type TOL6:Ven Arabidopsis thaliana
TOL6:ubq I44A:Ven was not compromised in functionality Arabidopsis thaliana
GFP-Mp myosin XI-tail acts as dominant negative Arabidopsis thaliana
glycolytic enzymes are well-known examples of moonlighting proteins
similarities between diatom Lhcx and LhcSR proteins is based on assumption of direct activation of Lhcx proteins
PfLCAT-PLA may have currently unknown physiological functions in non-seed tissues Physaria
3D structure of signaling peptides and effectors is important for functions of (ASL29, LBD27, SCP, AT3G47870) and Alt-A1 effectors
intron-encoded proteins (IEPs) contain maturase domain
N-terminal acidic domain is directly involved in functional specialization among (ATTOC159, PPI2, TOC159, TOC160, TOC86, AT4G02510) family receptors Arabidopsis thaliana
kelch motif-containing superfamily members have diverse activities
repetitions in C-terminal region of (AtDRB1, DRB1, HYL1, AT1G09700) suggest functionality of C-terminal region
function of (ADT5, AT5G22630) in the nucleus is currently unknown
ribosomal protein-defective mutants highlight extra and unique functions of ribosomal proteins
ubiquitin-binding domain-containing proteins and their potential post-translational modifications illustrates how ubiquitin receptors can control cellular functions
oligosaccharides released from AGPs might execute function of AGPs
C-terminal truncation mutants (Δ9 and Δ33) in yeast Mrs6p (REP) are viable and only marginally affected in function Saccharomyces cerevisiae
non-vesicular ER to Golgi transfer of PtdIns does not reflect critical (ATSEC14, SEC14, AT4G39180) activity in vivo
phosphorylation potential of C-terminal region suggests functionality of C-terminal region
Ala111Thr substitution between the Clipper and Sahara 3771 HvCBL4 proteins is located outside of regions expected to participate directly in homodimerization, Ca2+ binding, N-myristoylation, S-acylation, or binding to a (ATSOS2, CIPK24, SNRK3.11, SOS2, AT5G35410) homologue protein Hordeum vulgare
transplastomic tobacco line HisBjCHI1-4 has chitinase activity of 0.028 U μg−1 min−1 Nicotiana tabacum
G225 of GhECR2 was shown to be essential for GhECR2 activity Gossypium hirsutum
(AHG1, AT5G51760) and (AHG3, ATPP2CA, PP2CA, AT3G11410) have overlapping and distinctive functions Arabidopsis thaliana
V352E substitution may confer protein stability or stimulate (ACS2, AT-ACC2, AT1G01480) catalytic activity Solanum lycopersicum
G40 residue in (FLA19, AT1G15190) has indispensable roles in the normal function of FLA19s in plants
RALPHs lack of RNase activity may suggest structural scaffold role
sequence modification to S-subunit residues far from catalytic sites on L-subunit have pervasive effect on kinetic properties of enzyme
I231 of GhECR2 was shown to be essential for GhECR2 activity Gossypium hirsutum
native folds are required for activity of some (ASL29, LBD27, SCP, AT3G47870)
sugar chain modification may directly affect protein function
(TOL6, AT2G38410) mislocalization results in overall loss in functionality
high sequence similarity (92%) suggest potential for redundant substrates Arabidopsis thaliana
ferredoxin affinity of p FNR changes with different N-terminal start points Triticum aestivum
WUS-box is essential for all activities of (PGA6, WUS, WUS1, AT2G17950) Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) was previously reported as MULTIPLE ANTIBIOTIC RESISTANCE 1 (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) Arabidopsis thaliana
Frq1 is essential Pik1 co-factor
all subunits of plant AGPase are required for normal enzyme function
(SPPA, SPPA1, AT1G73990) structure suggests that only one of the catalytic domains is active
(ATSAGT1, GT, SAGT1, SGT1, UGT74F2, AT2G43820) has multiple sites of action inside the cell Arabidopsis thaliana
plant targets of RKN candidate effectors suggest a role inside plant cells
p FNRI KKVS has highest catalytic efficiency of four p FNR isoforms Triticum aestivum
ability of enzyme to move and change shape might be important in holding ferredoxin substrate Triticum aestivum
increase in thylakoid membrane-associated Rubisco activase (TM–RCA) under conditions without heat stress indicates TM–RCA may have other unrecognized functions besides protection
distinct subcellular localization patterns might account for distinct functions of (ARAC4, ATRAC4, ATROP2, ROP2, AT1G20090) and (ARAC3, ATROP6, RAC3, RHO1PS, ROP6, AT4G35020) Arabidopsis thaliana
Egl-27 and MTA1 are functionally redundant Caenorhabditis elegans
(FMO GS-OX1, AT1G65860) is still functional after fusion with YFP
differences in phenotype must be caused by the expressed protein Arabidopsis thaliana
carbohydrate moiety of arabinogalactan proteins (AGPs) is crucial for functional diversity of AGPs
TRXz redox activity may be dispensable
post-translational modifications may not influence (CCT, CRP, MED12, AT4G00450) functions
(AtVIP1, SUE3, VIP1, AT1G43700) is VIRE2-INTERACTING PROTEIN1 (AtVIP1, VIH2, VIP1, AT3G01310) Arabidopsis thaliana
N-terminal flap (and its length) plays an important role in holding ferredoxin substrate Triticum aestivum
MPR1 might serve some physiological function
type V barley is likely to be affected in (PPO, TOPP2, AT5G59160) activity Hordeum vulgare
transplastomic tobacco line HisBjCHI1-4 shows greater than 2-fold increase in chitinase activity Nicotiana tabacum
increase in Trx activity at 14 days of treatment implied that PsTrx o 1 is active in this condition Pisum sativum
aberrant tertiary structure causes inactivity Pisum sativum
transglycosylase enzymatic (XET) activity and xyloglucan hydrolase activity (XEH) are not correlated with protein structure
electronegative surface of CrTRXz supports important function for type-z physiological functions in plants Chlamydomonas reinhardtii
BjCET3 and BjCET4 may have similar functions in the plant Brassica juncea
molecular mechanism of action of AGPs is still elusive Arabidopsis thaliana
p FNRI SKKQ has half the catalytic efficiency of p FNRI KKVS Triticum aestivum
(ATPUMP1, ATUCP1, PUMP1, UCP, UCP1, AT3G54110) homologues ( (ATUCP2, PUMP2, UCP2, AT5G58970) and (UCP3, AT1G14140) in mammals, plant ) have physiological role that continues to be a matter of intense debate
(EMB2444, JANUS, AT2G18510) kinases (JAKs) have two-faced function
(SPT, AT4G36930) may often have redundantly acting partners Arabidopsis thaliana
(CCT, CRP, MED12, AT4G00450) motif is critical functional domain for transcription factors Oryza sativa
aberrant basal behavior of FLAGELLIN SENSING 2 (ATFLS2, FLS2, AT5G63580) C1132,1135 S mutant does not exist when compared with FLAGELLIN SENSING 2 (ATFLS2, FLS2, AT5G63580) Arabidopsis thaliana
purified SIE141 determined to be biologically active in co-incubation with (ATCDSP32, CDSP32, TRXL1, AT1G76080) in enhancing oxidoreductase activity
cyclophilins encode unique functions
Met-309 to Ile substitution could not explain altered kinetic phenotype
cloned FA encodes functional protein Capsicum frutescens; Arabidopsis thaliana
C-terminal half of R2R3-MYB proteins confers specific biological functions Arabidopsis thaliana
galectin/galactose-binding domain can be found in a number of glycosyltransferases
FDM1-reporter relocation coincided with defects in additional members of gene family Arabidopsis thaliana
plant PP2C isoforms are associated with diverse functions Arabidopsis thaliana; Oryza sativa
SNP at position 618 in Ghd7 is located in (CCT, CRP, MED12, AT4G00450) motif Oryza sativa
Topo6B has conserved ATP binding and hydrolysis domains
seedlings from all three different seed classes of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) homozygous mutant lack (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) activity Arabidopsis thaliana
Arabidopsis ACBPs with similar subcellular localization and binding affinities may share overlapping roles Arabidopsis thaliana
predicted domains were functional
ARM repeat domain could represent structural or protein interaction domain unique to the functions of plant and protozoan FU proteins
structural disorder of RNA chaperones is considered to be important for RNA chaperone function
loss of mid-SUN proteins cannot be functionally compensated by Cter-SUNs Arabidopsis thaliana
(PAP10, TRX P, TRX z, AT3G06730) stands out from other TRXs that appear to have at least overlapping functions Arabidopsis thaliana
present data do not rule out function for (ATIPT1, IPT1, AT1G68460) in the cytosol and mitochondria Physcomitrella patens
differences in protein interaction strength have bearing on functional significance of protein complexes in planta
(FER, AT3G51550) can adopt at least two active configurations Arabidopsis thaliana
R588 residue is not part of QXXRW motif (791–795 in OsCesA9) Oryza sativa
grass CCR proteins possess NADPH binding site
alternative splicing regulates enzymatic characteristics
AtRPL10B expressed under GDP promoter showed complementation with lower growth rate than endogenous (RPL10, RPL10A, SAC52, uL16z, AT1G14320) protein Saccharomyces cerevisiae
DAGK fusion proteins retained activity Escherichia coli
RING FINGER OF SEED LONGEVITY1 (RSL1)/RING FINGER ABA-RELATED (RFA) E3 ligases family show distinct functions
glycosylphosphatidylinositol (GPI) anchoring is crucial for protein function
PUB-ARM proteins may possess plant-specific functions Marchantia polymorpha
secreted 8CM is sufficient for HyPRP1 functions Capsicum annuum; Nicotiana benthamiana
novel roles of prolyl isomerases are unrelated to heat-shock response Arabidopsis thaliana
Vitreoscilla VHb may substitute the function of endogenous hemoglobins (Hbs) hybrid aspen
RfCTD is essential for proper functioning of (RPF2, AT1G62670) (NAD6, ATMG00270) protein in mitochondria
SDE2-UBL plays regulatory role in Schizosaccharomyces pombe and Homo sapiens Schizosaccharomyces pombe; Homo sapiens
DAGK fusion proteins remain functional
carbohydrate-binding modules (CBM) enable substrate selection and localization
AtRPL10C expressed under GDP promoter showed complementation with lower growth rate than endogenous (RPL10, RPL10A, SAC52, uL16z, AT1G14320) protein Saccharomyces cerevisiae
complex interaction and heterologous γ subunit function does not require GBD
VirE2-GFP11 is functional like VirE2
ANU10:GFP fusion protein retains sufficient activity to complement anu10-1 mutant phenotype Arabidopsis thaliana
Tyr224 reveals the essential role of this tyrosine Arabidopsis thaliana
(AtERF#092, ERF1, ERF1B, AT3G23240) binding partners determine (AtERF#092, ERF1, ERF1B, AT3G23240) function
Tyr207 suggests important role
some Arabidopsis ACBPs perform distinct cellular functions in vivo Arabidopsis thaliana
BnaGLN1.2 and BnaGLN1.3 protein conserves K49 and A174 residues Brassica napus
SlCDF genes display additional functions Solanum lycopersicum
closely related WRKY proteins such as (ATWRKY18, WRKY18, AT4G31800) (ATWRKY40, WRKY40, AT1G80840) and (ATWRKY60, WRKY60, AT2G25000) have revealed cooperative effects of functional interactions Arabidopsis thaliana
truncated protein could retain some enzymatic function Zea mays
FDM reporter proteins provides evidence for distinct roles of FDM proteins Arabidopsis thaliana
TaNPSN11/TaSYP132 interaction suggests functional differences among NPSN members Triticum aestivum
C terminus of (MSL3, AT1G58200) is required for function separable from MS-ion-channel activity Arabidopsis thaliana
engineering increasingly positive charge into (OPS, AT3G09070) phosphosite creates progressively more active (OPS, AT3G09070) variants Arabidopsis thaliana
water permeability is only one of multiple functions of AQPs
AtMRI R240C structural variant functions as overactive protein version Arabidopsis thaliana
truncated product of 69 000 kDa may still demonstrate partial activity Chlamydomonas reinhardtii
truncated (ATTOP6B, BIN3, HLQ, HYP6, RHL3, TOP6B, AT3G20780) protein has mutation of a highly conserved aliphatic residue in the ATP-binding site Arabidopsis thaliana
transport is third largest functional category of triticale stigma proteins Triticale
This situation suggests that this variant may interfere weakly with endogenous LEAFY (LFY, LFY3, AT5G61850) protein Arabidopsis thaliana
Arabidopsis (AKIN10, KIN10, SnRK1, SnRK1α1, SNRK1.1, AT3G01090) regulatory subunit gamma (KINγ; (KING1, KINgamma, AT3G48530) ) was not shown to complement yeast (ATSNF4, KINbeta-gamma, SNF4, AT1G09020) γ subunit mutant Arabidopsis thaliana
βγ subunit functionally complements yeast γ subunit (ATSNF4, KINbeta-gamma, SNF4, AT1G09020) mutant
GOLD but not the CC domain in p24δ5 required for effect of p24δ5 on steady-state localization of ERD2a and on secretion of HDEL ligands Nicotiana tabacum
GT14 family currently little functional knowledge regarding in plants Arabidopsis thaliana
altered secondary or tertiary structures of (ZAR1, AT3G50950) protein could affect protein functions of (ATSS1, SS1, AT5G24300) and (ATNS1, NS1, OVA8, AT4G17300) alleles Zea mays
distinct but somewhat overlapping nature of both structure and expression would make it possible for complex functional interactions among closely related WRKY proteins Arabidopsis thaliana
(FDM1, IDNL1, IDP1, AT1G15910) relocation to cytoplasm is further suggestive of essential role for cytoplasmic FDM localization Arabidopsis thaliana
ASR1-family proteins probably have dual functions as chaperones in cytosol and transcriptional regulators in nucleus
(EMB2279, EMB88, SOT5, AT1G30610) encoding the 978-amino acid polypeptide is functional Arabidopsis thaliana
(OHP, OHP1, PDE335, AT5G02120) and (OHP2, AT1G34000) have distinct functions Arabidopsis thaliana
role of CC in Rx1 is probably relatively small
two proteases ( (CLPR4, HON5, AT4G17040) and (FTSH2, VAR2, AT2G30950) ) function independently Arabidopsis thaliana
heterologous γ subunit function depends on highly conserved CBS domain
one truncating (PGRL2, AT5G59400) mutation rendered PGR5-LIKE2 (PGRL2, AT5G59400) function Arabidopsis thaliana
rhm1-2 and rhm1-3 alleles have compensatory effects on (ATRHM1, RHM1, ROL1, AT1G78570) function Arabidopsis thaliana
the D1 domain in Arabidopsis is dispensable for AtBASL function Arabidopsis thaliana
(PRT1, AT3G24800) is one of two characterized RING-domain proteins with functional requirement for RING domain Arabidopsis thaliana
phosphorus is necessary for enzyme activation
(RCA, AT2G39730) sensitivity is conferred by two Cys residues in the carboxy terminus of the α-isoform
remaining protein sequence is important for full protein function Arabidopsis thaliana
SNP and resulting substitution of Asp with Gly in coiled-coil domain caused loss of ATPase activity in (PAS2, PEP, PEPINO, AT5G10480) Cucumis sativus
each sampled species is likely to have at least one fully catalytic ClpP subunit
TILLING point mutations may not fully disrupt protein function Arabidopsis thaliana
YFP or CFP tag may interfere with HEMERA (HMR, PAP5, PTAC12, TAC12, AT2G34640) function Arabidopsis thaliana
8CM-containing proteins include those with lipid transfer function
START domain proteins show overlap between developmental and disease-related gene functions
mis-regulated proteins in clpR4-3 are mainly enriched in protein folding and degradation, PSII biogenesis, plastid gene expression, oxidative defense, carbohydrate metabolism Arabidopsis thaliana
novel forms of a protein have new functions
closely related WRKY proteins such as (ATWRKY18, WRKY18, AT4G31800) (ATWRKY40, WRKY40, AT1G80840) and (ATWRKY60, WRKY60, AT2G25000) have revealed antagonistic effects of functional interactions Arabidopsis thaliana
RING-finger domain in STF family proteins is unclear whether critical for mobility properties and opposite symbiotic functions Glycine max
individual cyclophilins was found to be not essential Saccharomyces cerevisiae
CPA2 is dispensable for growth and virulence in the presence of Cpa1 Cryptococcus neoformans
tomato LeSNF4 γ-like subunit did complement yeast (ATSNF4, KINbeta-gamma, SNF4, AT1G09020) γ subunit mutant Solanum lycopersicum
GBD may have plant-specific functions
mutations in helicase motifs I and Ia abolish ATPase activity Saccharomyces cerevisiae
number of interacting partners of OsSUV3 suggests that OsSUV3 might be involved in diverse cellular activities Oryza sativa
octuplet mutant lacking all eight cyclophilins showed little or no evidence for functional redundancy Saccharomyces cerevisiae
amino-terminal region in some BBK proteins is shown to have functional role
the inability to self-associate leads to a non-functional protein Arabidopsis thaliana
22 unique mis-regulated proteins in 47-2 function in same processes as described for (CLPR4, HON5, AT4G17040) Arabidopsis thaliana
truncated β3 protein is functional in yeast cells
cysteine residue C187 is important for enzyme activity Euonymus alatus
STD1 kinesin motor domain contains three well-conserved ATP binding sites Oryza sativa
recombinant protein GST-DRIF1 was functional Escherichia coli
MAIN-LIKE1 (MAIL1, AT2G25010) is plant-specific aminotransferase-like protein with plant mobile domain Arabidopsis thaliana
serine residue S253 is essential for EaDAcT activity Euonymus alatus
single or double amino acid residues differed between GSTs with low and high activity Vitis vinifera; Zea mays; Arabidopsis thaliana; Petunia hybrida
full length of (NRPB1, RNA_POL_II_LS, RNA_POL_II_LSRNA_POL_II_LS, RPB1, AT4G35800) CTD function is unknown in plants
(AT-NHX1, ATNHX, ATNHX1, NHX1, AT5G27150) proteins bearing deletions of the CBD were unable to suppress sensitivity of the (AT-NHX1, ATNHX, ATNHX1, NHX1, AT5G27150) mutant to HygB Saccharomyces cerevisiae
deletion of 16 amino acids (194–209) including the last 4 amino acids of PAP/5A core region completely abolished nucleotidyl transferase activity of (HESO1, AT2G39740) Arabidopsis thaliana
(ATSYP73, SYP73, AT3G61450) fusion is functional Arabidopsis thaliana
conserved sequence motifs are critical as protein domains Zea mays
(BZR1, AT1G75080) 2K/R-GFP was acting in dominant-negative manner Arabidopsis thaliana
protein in Mp spl1-35 GOF was likely functional transcription factor Marchantia polymorpha
phenotypes conferred by N-terminally tagged SAUR19–24 fusion proteins are the result of gain-of-function activity conferred by the tag Arabidopsis thaliana
protein–protein interactions will validate hypothesis about class II TPS protein function Zea mays
COMATOSE (ABCD1, ACN2, AtABCD1, CTS, PED3, PXA1, AT4G39850) transporter requires both halves for function Arabidopsis thaliana
loss of SBP domain abolishes transcription factor function Marchantia polymorpha
group I family of plant formin proteins could act in parallel mechanism to NET1 and NET2 Arabidopsis thaliana
rhm1-2 and rhm1-3 missense mutants may have antimorphic activity Arabidopsis thaliana
three of six convergent shifts in FT were in active sites or binding sites
WW domain of (TGS1, AT1G45231) suggests other unknown activities
composition of individual complexes bestows functional flexibility Arabidopsis thaliana
lack of HisPheAsp motif in expansin-like (AtNPF6.3, ATNRT1, B-1, CHL1, CHL1-1, NPF6.3, NRT1, NRT1.1, AT1G12110) protein might indicate that it functions differently than α-expansins and β-expansins
multiple C2 domains in MCTPs may be cooperative to play important role in mediating MCTP interaction with target protein(s), their subcellular localization, and subsequent biological effects Arabidopsis thaliana
local disruptions of CC structure were tested for impact on interactions of CC with NB-ARC-LRR and (RANGAP2, AT5G19320) and functionality of Rx1 Solanum tuberosum
suppressive activity by CC domain appears specific
loss-of-function mutants of (RPS2, uS2C, ATCG00160) with changes in nucleotide-binding site do not display suppressive effect Arabidopsis thaliana
family of EF hand Ca-binding motif containing calmodulin-like (CML) proteins are of unknown function Arabidopsis thaliana
YISY motif is characteristic essential for RALF activity
AtRPL10B-GFP fusion protein can complement (RPL10B, uL16y, AT1G26910) mutant plants Arabidopsis thaliana
qSW5 / GW5 encodes calmodulin-binding protein Oryza sativa
GBD (glycogen-binding domain) in AMPK has been evaluated for function
promoter swap experiment with (112A-2A, EMB30, GN, GNOM, MIZ2, VAN7, AT1G13980) and (ERMO1, GNL1, AT5G39500) revealed that (112A-2A, EMB30, GN, GNOM, MIZ2, VAN7, AT1G13980) can substitute (ERMO1, GNL1, AT5G39500) functions Arabidopsis thaliana
E domain is not thought to have catalytic function Arabidopsis thaliana
four amino acid residues involved in Ca2+ binding in classical calpains are essential for (ATDEK1, DEK1, EMB1275, EMB80, AT1G55350) in vivo function
disruption of conserved R3 domain and bHLH-interaction motif in AhMYB2.2 might impair function of AhMYB2.2 isoform Amaranthus hypochondriacus
difference in size (179.24 kDa vs 111 kDa) and amino acid sequence between NlVgC and LsVgC may explain difference in functions of NlVgC and LsVgC
mature peptide of NCR341 cannot substitute for NCR343 Medicago truncatula
PI4Kβs could have other kinase activity independent of PI4K activity Arabidopsis thaliana
activity of IDRs positively correlated with net charge
(ATIRE1-2, AtIRE1A, IRE1-2, IRE1A, AT2G17520) and (ATIRE1-1, AtIRE1b, IRE1, IRE1-1, IRE1B, AT5G24360) have functional endonuclease domains Arabidopsis thaliana
AtRPL10A expressed under (RPL10, RPL10A, SAC52, uL16z, AT1G14320) promoter showed complementation with slower growth rate than (GAL1, GALK, AT3G06580) promoter Saccharomyces cerevisiae
three independently confirmed proteins (OMT, GXM, HMT) has not been yet functionally characterized in barley Hordeum vulgare
rhm1-2 and rhm1-3 encode defective enzymes that can interfere with function of other UDP-rhamnose synthases through heterodimerization Arabidopsis thaliana
(ATCBL3, CBL3, AT4G26570) rely on PAT10 for functionality
suppression of autoactive Prf variants is specific Solanum lycopersicum
(ABC1, ABCI8, ATABC1, ATNAP1, LAF6, AT4G04770) ;3T plays dominant role over wild-type (ABC1, ABCI8, ATABC1, ATNAP1, LAF6, AT4G04770) proteins Arabidopsis thaliana
intron-encoded proteins (IEPs) contain endonuclease domain
N-terminal region of GIGANTEA (GI) is critical for GIGANTEA (GI) function
different proteins from AhMYB2 isoforms could add functional variation Amaranthus hypochondriacus
association of (RPL10, RPL10A, SAC52, uL16z, AT1G14320) with nuclear proteins suggests at least one of the (RPL10, RPL10A, SAC52, uL16z, AT1G14320) isoforms could have an extraribosomal function in the nucleus Arabidopsis thaliana
AtRPL10C expressed under (RPL10, RPL10A, SAC52, uL16z, AT1G14320) promoter showed complementation with slower growth rate than (GAL1, GALK, AT3G06580) promoter Saccharomyces cerevisiae
HopF4a further lacks a functional catalytic triad from peptide sequence alignments and appears to be an enzymatically nonfunctional member of the HopF family Pseudomonas syringae pv. actinidiae
F116 of 1-FFT in chicory was located in active site in β-propeller domain Cichorium intybus
antibacterial activity of the candidates can be ascribed to intrinsically disordered regions
DTN1 252L has remarkably decreased FBA activity compared with DTN1 252P Oryza sativa
Arabidopsis (RPL10, RPL10A, SAC52, uL16z, AT1G14320) proteins can complement Saccharomyces cerevisiae conditional lethal mutant in the (RPL10, RPL10A, SAC52, uL16z, AT1G14320) gene Arabidopsis thaliana; Saccharomyces cerevisiae
VmSpm1 contains Inhibitor_I9 domain Valsa mali
presence of all six universally conserved amino acids in U-box domain of MpPUB9 implies functional importance Marchantia polymorpha
μ2-YFP fusion protein was functional Arabidopsis thaliana
PEROXIDASE36 (PER36, PRX36, AT3G50990) amino acids have been partially identified responsible for interaction within the wall domain Arabidopsis thaliana
Gene Ontology enrichment analysis showed proteins were mainly related to translation, stress response, transport, and protein metabolic process Oryza sativa
intron-encoded proteins (IEPs) contain reverse transcriptase domain
UP9C may function in non-nuclear cellular compartments Nicotiana tabacum
presumed catalytically inactive isozymes can similarly have retained unsuspected catalytic side-activities in other families
I44A mutation in ubiquitin chimera completely restored the ability to function like wild-type TOL6:Ven Arabidopsis thaliana
(WTG1, AT5G53080) gene encodes unknown protein with a predicted otubain domain Oryza sativa
plant M3 peptidases have unknown cellular functions Arabidopsis thaliana
N-terminal protein region of (PLDrp1, AT5G39570) points to important function encoded in the N-terminus plant kingdom
site-directed mutagenesis identified various amino acids essential for acetyltransferase activity of Ea DAcT Euonymus alatus
conserved functional domains described for euAP2 transcription factors include two EAR motifs Prunus persica
other family members of (FTIP1, MCTP1, AT5G06850) may have evolved to function in antagonistic manner to (FTIP1, MCTP1, AT5G06850) Arabidopsis thaliana; Cucurbita moschata
heterologous γ subunit function depends on pre-CBS domain
calpains in Chlorophyta have no functional information available functional characterization
(ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) YG protein is functional in the absence of NA-PP1 Arabidopsis thaliana
island domain of (AtRLP10, CLV2, AT1G65380) is dispensable for (AtRLP10, CLV2, AT1G65380) function Arabidopsis thaliana
calmodulin (CaM) has no enzymatic activity
SAR DIX domains can substitute for (DVL2, RTFL19, AT3G02493) DIX
interactor has additional independent functions
some of the identified tomato SlCDFs, like SlCDF3 might have additional functions in tomato Solanum lycopersicum
truncated (ATPDK1, PDK1, AT5G04510) protein with a disrupted PH domain (0–408 aa) keeps most of its functionality
higher (ATCOP1, COP1, DET340, EMB168, FUS1, AT2G32950) protein levels in det1-1 mutant are associated with diminished (ATCOP1, COP1, DET340, EMB168, FUS1, AT2G32950) function in decreasing (HY5, TED 5, AT5G11260) abundance
persulfidation-induced protein structural change may relate to physiological phenomena
D/En regions of (nMAT3, AT5G04050) and (nMAT4, AT1G74350) contain amino acid alterations expected to inactivate endonuclease activities
(CLPR4, HON5, AT4G17040) protein is partially functional in (SOT7, AT1G28170) mutant Arabidopsis thaliana
(CLPR4, HON5, AT4G17040) and (PSB29, THF1, AT2G20890) function in distinct manner Arabidopsis thaliana
HSP90.3 and (ATHS83, AtHsp90-1, ATHSP90.1, HSP81-1, HSP81.1, HSP83, HSP90.1, AT5G52640) are redundant Arabidopsis thaliana
mutations in helicase motifs I and Ia abolish helicase activity Saccharomyces cerevisiae
deletion of end of repeat 1 and beginning of repeat 2 in M protein leads to loss of function of M protein
functional redundancy exists among Arabidopsis RING-domain proteins Arabidopsis thaliana
deletion of AGP domain may be destructive to the whole protein
Medicago MtSNF4b γ-like subunit did complement yeast (ATSNF4, KINbeta-gamma, SNF4, AT1G09020) γ subunit mutant Medicago truncatula
REP C-terminus could be involved in other functions than (RAB, RBE, AT5G06070) prenylation
Manganese (Mn) is a cofactor of cellular proteins
(ABCE2, ATRLI2, RLI2, AT4G19210) (RNase L inhibitor 2) is ATP binding cassette-type ATPase Cardamine hirsuta
(RbohH, AT5G60010) and (RbohJ, AT3G45810) have partially redundant functions
variants with combinations of residues in (AtTN10, TIR, TN10, AT1G72930) and NB domains exhibit reduced activity
series of BTB proteins has been identified and characterized with functions associated with multiple biological processes
(RPL10, RPL10A, SAC52, uL16z, AT1G14320) proteins may have extraribosomal functions in the nuclei Arabidopsis thaliana
multiples of an epitope tag are more likely to disrupt protein function
truncated LRX proteins with only parts of the LRR domain are very likely to be nonfunctional Arabidopsis thaliana
S4 and W90D appear to have different effects on functionality of Rx1
TOL6–ubiquitin fusion altered protein functionality
WG7 encodes CW domain-containing zinc finger transcription factor Oryza sativa
transgenic module did not contain any enzymatic activity Hordeum vulgare
SOUL heme-binding proteins in higher plant and algal plastoglobules have unknown function
both parts of NCR343 contain motifs that are indispensable for its functions Medicago truncatula
protein encoded by Os06g0138200 is predicted to contain 2OG-Fe (II) dependent oxygenase domain Oryza sativa L. ssp. japonica
S1 and Z3 mutations have little effect on functionality of full-length Rx1 protein
CC S1 still exhibits pronounced suppressive effect indistinguishable from wild-type CC
ribosomal proteins are considered housekeeping proteins
NDH-associated nuclear-encoded proteins may function as auxiliary proteins higher plants
autoactive variants of tomato NB-LRR Prf are suppressed when LRR of Prf is coexpressed Solanum lycopersicum
N-terminal half of LRR is crucial in suppression Triticum aestivum
AtRPL10A expressed under GDP promoter showed complementation with lower growth rate than endogenous (RPL10, RPL10A, SAC52, uL16z, AT1G14320) protein Saccharomyces cerevisiae
Tyr-308 in pea FNR was rotated into conformation that allows NADP+ binding Pisum sativum
nucleoside triphosphate hydrolase proteins functions of these proteins are even less understood than UspA domain proteins Arabidopsis thaliana
coexpression of CC domain of Bs2 does not affect activity of Rx1
GTPase activity of (GOM8, RHD3, AT3G13870) proteins was measured
OsLPLA and AtLPLA suggest similar catalytic features Oryza sativa; Arabidopsis thaliana
Substitution E572K in conserved third LRR of (EMB3113, PRPS5, RPS5, SCA1, uS5c, AT2G33800) inactivates Arabidopsis CC-NB-LRR (EMB3113, PRPS5, RPS5, SCA1, uS5c, AT2G33800) Arabidopsis thaliana
truncated protein sequestering binding partners in complex results in complex that is not signaling competent
cysteine residue C293 is important for enzyme activity Euonymus alatus
SOS2-∆308 is SOS3-independent form of kinase Arabidopsis thaliana
chemically synthesized polypeptides possess biological activities
(AAD6, FTM1, HUP7, SAD6, AT1G43800) protein neither rescued growth of nor altered unsaturated FA profile in yeast mutants and Escherichia coli cells Saccharomyces cerevisiae; Escherichia coli
ATP binding by (PBS1, AT5G13160) is essential under native protein levels but can be bypassed by overexpression Arabidopsis thaliana
specific ER localization of sHSP22 confers to sHSP22 unique functions distinct from other cytosolic sHSPs Arabidopsis thaliana
complex N-glycans are prerequisite for the in vivo activity of many therapeutically interesting proteins
extensin domain of (LRX11, AT4G33970) is required for protein function Arabidopsis thaliana
sulfur (S) is an important component of prosthetic groups
(AT-SYR1, ATSYP121, ATSYR1, PEN1, SYP121, SYR1, AT3G11820) and (ATSYP122, SYP122, AT3G52400) have strong redundancy from a general point of view
S121 and S280 of TaPIP2;10 are crucial residues Triticum aestivum
C-terminal fusion proteins of (REIL1, AT4G31420) and (FZF, REIL2, STCH4, AT2G24500) failed to be introduced into the mutant due to known requirement of an unaltered and intact C terminus for yeast Rei1 function Arabidopsis thaliana
atTic55-II does not resemble to degree that would lead to expect functional redundancy with AtPTC52 Arabidopsis thaliana
CC-NB-ARC of Pm3 proteins does not suppress activity of full-length proteins Triticum aestivum
PHBs (prohibitins) play important and diverse biological functions
salivary gland proteins have functions including binding, catalytic activity, and secretion
suppressive activity of wild-type CC compared to S1 and S4 mutants makes clear that suppression does not act via intramolecular interaction
(FAR2, MS2, AT3G11980) dampens TaRomo1 activity Triticum aestivum
C-terminal sequences of RxLR effectors rarely contain motifs that would suggest a known biochemical function Phytophthora
SOK5-YFP bearing a mutant KEY motif (E356Q/E359Q) shows no detectable changes in localization or biological activity
SAR DIX is functionally equivalent to (DVL2, RTFL19, AT3G02493) DIX regarding biochemical properties and signaling activity
two amino acid changes in missense mutations may suppress function of (RFL24, AT5G41170) Arabidopsis thaliana
glycine residue G55/G53 is critical for proper function of both proteins Arabidopsis thaliana
(VPS26A, AT5G53530) and (VPS26C, AT1G48550) have relatively low amino-acid sequence similarity redundant functions Arabidopsis thaliana
direct targets of itaconate are proteins involved in essential processes Arabidopsis thaliana
nontraditional nuclear localizations of metabolic enzymes implies previously unidentified functions beyond established catalytic roles
both pools of (HMR, PAP5, PTAC12, TAC12, AT2G34640) are essential for (HMR, PAP5, PTAC12, TAC12, AT2G34640) function Arabidopsis thaliana
multiple AtSnRK1 complexes with various αβγ subunit combinations may be involved in various functions Arabidopsis thaliana
cobs contain putative carbohydrate binding domains
acidic region of AK-6B is essential for nuclear localization, transactivation and induction of hormone independence in tobacco Nicotiana tabacum
structural flexibility could have similar advantages for fungal and oomycete antimicrobials
specific proteins in stromule microcompartments serve specialized functions Physcomitrella patens
A1ATs are molecular mouse traps
FP-tagged (AHA2, AtHA2, HA2, PMA2, AT4G30190) proteins signals likely reflect in vivo behavior of H+ -ATPase molecule Arabidopsis thaliana
single-nucleotide polymorphisms or insertions/deletions in coding regions may affect gene function
induced in trans interactions explain why coexpressed wild-type versions of domains transcomplement loss-of-function phenotype
identification of methionine sulfoxide reductase partners will help to gain insight into physiological roles of methionine sulfoxide reductases
single amino acid substitutions in the coiled-coil motif greatly changed ATPase activity
hypophosphorylated Serrate (SE) variants could readily rescue se-1 phenotypes
(TIE1, AT4G28840) (TIE2, AT2G20080) (TIE3, AT1G29010) and (TIE4, AT2G34010) may have similar biochemical functions Arabidopsis thaliana
site-directed mutant H382A abolishes complementation by pPMR5::PMR5-GFP construct
effector proteins in dot-shaped and filamentous structures remains to be established whether effector proteins are functional while in such structures
hyperphosphorylated Serrate (SE) variants could not readily rescue se-1 phenotypes
structural flexibility may facilitate translocation, function, and evasion of recognition of bacterial effectors
changes in amino acid sequence can affect activity of effectors in insects and pathogens
presence of unspliced transcript encoding truncated protein interferes with function of full-length protein Nicotiana benthamiana
113-amino acid protein size might imply protein structure or size requirement for function of executor proteins Oryza sativa
CrIRE1 might also have additional functions Chlamydomonas reinhardtii
analysis of (CLPP1, PCLPP, ATCG00670) acceleration has provided evidence of retained functionality at the protein level, even for one of the most extreme cases of (CLPP1, PCLPP, ATCG00670) divergence
non-functional TaMs5-D allelic form is predicted to encode non-functional protein Triticum aestivum
altered amino acid caused by rl mutation may be essential for CsPID function in cucumber Cucumis sativus
interference with assembly of SE-scaffolded macromolecule complexes compromised Serrate (SE) functions
(ATCOP1, COP1, DET340, EMB168, FUS1, AT2G32950) protein levels do not simply correlate with (ATCOP1, COP1, DET340, EMB168, FUS1, AT2G32950) activity
D364 and N364 in PPKL1 suggests competition relationship between D364 and N364 Oryza sativa
isolated mutations may have negative impact on protein activity and/or dimerization Glycine max
(ATCOP1, COP1, DET340, EMB168, FUS1, AT2G32950) is one of two characterized RING-domain proteins with functional requirement for RING domain Arabidopsis thaliana
(MAP18, PCAP2, AT5G44610) function via PtdIns(4,5)P2-binding activity on plasma membrane can be distinguished from (MAP18, PCAP2, AT5G44610) function via ROP2-binding activity by its dependence on N-myristoylation
putative protein encoded by grik1-2 allele retains some level of activity
(AtBCS1, AtOM66, BCS1, OM66, AT3G50930) ( ) encodes AAA ATPase Arabidopsis thaliana
specific biochemical function of N receptor interacting protein 1 (NRIP1) in the chloroplast remains unknown
CRL4 encodes protein highly homologous with Arabidopsis (112A-2A, EMB30, GN, GNOM, MIZ2, VAN7, AT1G13980) Oryza sativa; Arabidopsis thaliana
cop1-4 mutant combines loss-of-function phenotypes due to missing C-terminus Arabidopsis thaliana
VirE2 fusion is functional like wild type
subcellular localization of RKN candidate effectors when overexpressed in plant cells suggests a role inside plant cells
TaMS1 encodes GPI-anchored nsLTP Triticum aestivum
physical interactions between group Q UGTs and other proteins could be explored in future to determine function of surface regions of UGTs in forming metabolons and producing flavonoid glycosides
truncated (ATSNAK2, GRIK1, AT3G45240) expressed in -2 mutant could provide residual (ATSNAK2, GRIK1, AT3G45240) function Arabidopsis thaliana
functional specificity is to a large extent independent of DNA-binding specificity Arabidopsis thaliana
immunophilins were originally isolated as immunosuppressive drug receptors
ionic cellular distribution is critical for protein activity
full-length (APP1, AT5G53540) overexpression confirms special functional characteristics of active form rather than membrane-tethered form of (APP1, AT5G53540) Arabidopsis thaliana
RIBOSOMAL PROTEIN L10 (RPL10, RPL10A, SAC52, uL16z, AT1G14320) has additional extraribosomal functions extraribosomal functions
proline to threonine substitution in Kasalath NOMT is the main cause of lower enzymatic activity of NOMT in Kasalath Oryza sativa
GSNOR1 C10S mutation does not have detectable effect on enzymatic activity
regulatory properties of the α-form (RCA, AT2G39730) in maize may differ from regulatory properties of (RCA, AT2G39730) in other species Zea mays
AtFNR1 and AtFNR2 have partly redundant function Arabidopsis thaliana
cargo-dependent AGO sub-cellular localization hypothesis may be applicable to other AGOs
GAFP1 has been demonstrated to be mannose-binding lectin
single amino acid exchange leads to drastic change in substrate specificity
amino acid substitutions at the predicted substrate binding sites suggest potential divergence in enzyme efficiency
amino acid substitutions in Group 5 proteins might result in inability to bind glucose or ATP
correct glycosylation pattern may contribute to functioning of the mature protein
version with non-functional ubiquitin tag behaves like wild-type version of (TOL6, AT2G38410) Arabidopsis thaliana
Arabidopsis thaliana AN (AtAN) does not exhibit dehydrogenase activity Arabidopsis thaliana
Lz region of LOB domain in LBD gene family is critical to specific function of LBD
oligomeric forms larger than hexamers are proposed to be inactive in ATP hydrolysis
TOL6:ubq I44A:Ven construct was not compromised in functionality Arabidopsis thaliana
PUB family proteins have roles in self-incompatibility, hormone responses, defense and abiotic stress responses
potato R3a resistance protein becomes nonfunctional Solanum tuberosum
suppressive effect of Rx1 CC is set apart from suppression of autoactivity of chimeric Mi constructs by coexpressed N-terminal SD domain Solanum lycopersicum
substitution of (AtCLE6, CLE6, AT2G31085) signal peptide with rice signal peptide attenuated overexpression phenotypes of (AtCLE6, CLE6, AT2G31085) Arabidopsis thaliana
(AtNPC4, NPC4, AT3G03530) S-acylation determines (AtNPC4, NPC4, AT3G03530) function Arabidopsis thaliana
Reversibly Glycosylated Protein (RGP, RGP3, AT3G08900) may carry out more than one function
(AtATL78, ATL78, PRU2, AT1G49230) is E3 ligase localized to plasma membrane Arabidopsis thaliana
SOSEKI DIX is functionally equivalent to (DVL2, RTFL19, AT3G02493) DIX regarding biochemical properties and signaling activity
moonlighting proteins are proteins with multiple independent functions
plant-specific functions could be compromised in rep-1 line Arabidopsis thaliana
GEF catalytic activity of (112A-2A, EMB30, GN, GNOM, MIZ2, VAN7, AT1G13980) on membrane is regulated by conserved Sec7 domain Arabidopsis thaliana
(MDKIN2, AT2G22610) function will be related to cargo or protein binding ability Arabidopsis thaliana
type II ROPs are unlikely to substitute for (ARAC4, ATRAC4, ATROP2, ROP2, AT1G20090) in plp-3 Arabidopsis thaliana
single aminoacid substitution in Fas1-2 domain in sos5-1 allele disrupted FLA4 function to the level of knock out allele sos5-2 Arabidopsis thaliana
nuclear localization signal (NLS) is unnecessary for phenotypic complementation of the an mutant Arabidopsis thaliana
glucose sensor function of Arabidopsis (ATHXK1, GIN2, HXK1, AT4G29130) can be uncoupled from catalytic activity Arabidopsis thaliana
point mutation Asn60Gly in AQP6 converted AQP6 from an anion channel to a water channel Homo sapiens
conserved PSPG motif plays critical role in direct interaction with UDP-sugar donor Strobilanthes cusia
substitution of CLE signal peptides with rice GRP signal peptide affected gain-of-function phenotypes of some CLE proteins Arabidopsis thaliana
SPY catalytic activity is important for SPY function Arabidopsis thaliana
cop1-6 allele has residual (ATCOP1, COP1, DET340, EMB168, FUS1, AT2G32950) action Arabidopsis thaliana
(ATFTSZ2-1, FTSZ2-1, AT2G36250) and (FTSZ2-2, AT3G52750) proteins were reported to have biochemically equivalent functions within FtsZ2 pool Arabidopsis thaliana
each of the seven histidines in (FAD4, FADA, AT4G27030) are essential Saccharomyces cerevisiae
mutation L776H in the (ATHAK5, HAK5, AT4G13420) protein earlier shown to be important for functional expression of (ATHAK5, HAK5, AT4G13420) in yeast Arabidopsis thaliana; Saccharomyces cerevisiae
N-glycans are responsible for stability and biological activity of glycoproteins
(ZAR1, AT3G50950) resistosome does not mean that all CNLs function as calcium channels
N terminus of (ATPRMT3, PRMT3, AT3G12270) is required for biological functions of (ATPRMT3, PRMT3, AT3G12270) Arabidopsis thaliana
AhHMA4 protein might exhibit reduced activity in tobacco Nicotiana tabacum
UBD-mutated (TOL6, AT2G38410) allele exhibits altered localization and complete loss of functionality
evolutionary conservation of dual targeting of Fum suggests important conserved moonlighting function of cytosolic Fum in eukaryotes eukaryotes
C terminus of (AVB1, IFL, IFL1, REV, AT5G60690) (specifically, the Per-ARNT-Sim-like MEKHLA domain) is particularly important in regulating (AVB1, IFL, IFL1, REV, AT5G60690) activity Arabidopsis thaliana
BPH-secreted proteins have not yet been experimentally determined in function functions of majority of BPH-secreted proteins Nilaparvata lugens
multiple C2 domains in (FTIP1, MCTP1, AT5G06850) have revealed specific roles of each C2 domain in (FTIP1, MCTP1, AT5G06850) Arabidopsis thaliana
systematic analysis of 16 genes in the entire Arabidopsis MCTP family reveals potential functional divergence or redundancy of MCTP members Arabidopsis thaliana
CC S4 and CC-NB-ARC S4 constructs lost ability to suppress activity of full-length Rx1
amino acid residue at position 101/107 may have functional significance Hordeum vulgare
(AtWTF1, WTF1, AT4G01037) and (emb1692, LEFKO, AT5G62990) are not redundant in terms of functional properties
(NTRC, AT2G41680) is enzyme able to act as NTR/TRX system in single polypeptide