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mapk signaling

8965 relationships annotated with this phrase. Showing first 500 of 8965.
Source entity Relationship Target entity Species
SlMPK6 is significantly upregulated in Bg_9562 protein-treated leaves during 30 min to 6 h of treatment Solanum lycopersicum
rapid activation of MAPK cascades upon PAMP treatment prompted testing of whether S/TP sites are the major phospho-sites of (PAP3, PIF3, POC1, AT1G09530) in response to flg22 Arabidopsis thaliana
(ATEDR1, EDR1, AT1G08720) regulates MKK accumulation via modulation of E3 ligases
MRK1, RAF26, and RAF39 inability to phosphorylate Arabidopsis MKKs suggests they likely do not function as canonical MKKKs in vivo Arabidopsis thaliana
mitogen-activated protein kinase (MAPK) signaling acts in a concerted manner to determine physiological and pathological responses to a wide variety of extracellular and intracellular stimuli
(M3Kdelta1, MKD1, RAF3, AT5G11850) phosphorylation of (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) occurs at Thr215 and Ser221 (within the S/T-X3-5-S/T motif)
some Raf-like kinases can phosphorylate MKKs
RiMsn2 may directly interact with upstream RiHog1 protein from Rhizophagus irregularis Rhizophagus irregularis
SlMPK3 is not significantly upregulated in peptide 2-treated leaves during 30 min to 6 h of treatment Solanum lycopersicum
phospho-MAPK detection used to verify MAPK pathway activation upon B. cinerea infection Solanum lycopersicum
rice ortholog of (ATEDR1, EDR1, AT1G08720) associates with but does not phosphorylate OsMKK10.2 Oryza sativa
BcPG1 NSP infiltration in tomato leaves triggered activation of MAPK signaling Solanum lycopersicum
SlMAP2K2 DD (Thr215 and Ser221 mutated to Asp215 and Asp221) is phosphor-mimic constitutive activation form of MAP2K2 Solanum lycopersicum
SlMAP3K18 4D (SlMAP3K18 T45D, S49D, S76D, and S135D) is constitutive activation form Solanum lycopersicum
(ATMAP65-1, MAP65-1, AT5G55230) is phosphorylated by mitogen-activated protein kinase (MAPK)
mitogen-activated protein kinase (MAPK) cascades contain MAPKs
(ATEDR1, EDR1, AT1G08720) associates with (ATMEK4, ATMKK4, MKK4, AT1G51660) and (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220)
SlFERL may phosphorylate SlMAP3K18 Solanum lycopersicum
(ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) are activated in OE lines during 1 and 3 dpi of R. solanacearum infection Solanum lycopersicum
MAP2K4 phosphorylation status is necessary for biochemical functions relevant to cell death phenotype Nicotiana benthamiana
SlMPK6 is significantly upregulated in peptide 1-treated leaves during 30 min to 6 h of treatment Solanum lycopersicum
SlMPK6 is not significantly upregulated in peptide 2-treated leaves during 30 min to 6 h of treatment Solanum lycopersicum
MRK1, RAF26, and RAF39 cannot phosphorylate any of the 10 Arabidopsis MKKs Arabidopsis thaliana
VIGS-MAP2K2 and VIGS-MAP3K18 plants showed MAPK activity that did not change significantly upon B. cinerea infection Solanum lycopersicum
SlFERL (Solanum lycopersicum FERONIA Like) fine-tunes MAPK signaling Solanum lycopersicum
SlFERL (Solanum lycopersicum FERONIA Like) triggered downstream signaling by phosphorylating SlMAP3K18 Solanum lycopersicum
SlERF.C1 is under the regulation of MPK pathways Solanum lycopersicum
ubiquitin-specific protease 15 (UBP15, AT1G17110) has as substrate mitogen-activated protein kinase Gpmk1 Fusarium graminearum
serine-proline-rich protein homolog (SlSPRH1) is substrate of SlMPK1 Solanum lycopersicum
StVIK is Raf-like MAP3K and member of subgroup C1 Solanum tuberosum
(ANP2, MAPKKK2, NP2, AT1G54960) (ANP3, AtANP3, MAPKKK12, NP3, AT3G06030) mutant phenotype is similar to (ATMPK4, MAPK4, MPK4, AT4G01370) mutant Arabidopsis thaliana
MAPK cascades play key roles in plant growth and stress signaling
(ATMEK4, ATMKK4, MKK4, AT1G51660) (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) and (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) form a MAP kinase cascade with MAPKKK YODA Arabidopsis thaliana
(ATMKK3, MKK3, AT5G40440) has been previously shown to activate (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
mitogen-activated protein kinase (MAPK) cascade consists of MAPK, MAPK kinase (MAPKK or MKK) and MKK kinase (MAPKKK or MEKK)
MAPK cascades in plants have been identified in cell division
summ4-1D (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) /2 plants shows restoration of flg22-induced activation of MAP kinases Arabidopsis thaliana
MPK4-HA-YCE expressed in wild-type protoplasts is activated upon treatment with flg22 Arabidopsis thaliana
activated MAPKs have downstream targets including transcription factors
SlMPK1-mediated homologous proteins were also observed in Arabidopsis MAPKKK double mutant anp2anp3 Arabidopsis thaliana
SlIDA signal function in mediating tomato pollen development and ROS levels might also require MAPK cascades Solanum lycopersicum
ARABIDOPSIS SER/THR PHOSPHATASE OF TYPE 2C 1 (AP2C1, AT2G30020) inactivates mitogen-activated protein kinase (MAPK) (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
mitochondrial oxidative burst results in the activation of MITOGEN-ACTIVATED PROTEIN KINASE3 (ATMAPK3, ATMPK3, MPK3, AT3G45640)
vesicular trafficking inhibitors did not affect flg22-induced mitogen-activated protein kinase phosphorylation Arabidopsis thaliana
SlSPRH1 acts downstream of SlMPK1 is suggested by S44A mutation blocking SlMPK1-mediated inhibition Solanum lycopersicum
Arabidopsis NPK1-related Protein kinases (ANP1, MAPKKK1, NP1, AT1G09000) (ANP2, MAPKKK2, NP2, AT1G54960) and (ANP3, AtANP3, MAPKKK12, NP3, AT3G06030) are three MAPKKKs closely related to NPK1 Arabidopsis thaliana
MAPK kinases (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) and (ATMKK2, MK1, MKK2, AT4G29810) are part of MAPK cascade
MAPK cascades are highly conserved
47-kD MBP-phosphorylated protein (p47-MBPK) is identified as SlMPK1 Solanum lycopersicum
MAPK cascades in plants have been identified in development
Yoda-MKK4/MKK5-MPK3/ (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) MAP kinase cascade is studied extensively Arabidopsis thaliana
(ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) and (ATMKK2, MK1, MKK2, AT4G29810) are required for activation of (ATMPK4, MAPK4, MPK4, AT4G01370) by flg22 Arabidopsis thaliana
MAPK cascades modulate cellular responses to diverse cues
activated MAPKs have downstream targets including protein kinases
flg22 treatment induces activation of phosphorylated (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
phosphorylation of microtubule-associated proteins (MAPs) by mitogen-activated protein kinase (MAPK) pathway is conserved among various species
constitutively active MAPK (CA-MPK) mutants specificity toward known activators and substrates appears to be unchanged in known activators and substrates Arabidopsis thaliana
anp2-2 anp3-3 double mutant crossed with transgenic line expressing constitutively active (ATMPK4, MAPK4, MPK4, AT4G01370) (CA- ) mutant Arabidopsis thaliana
SlERF.C1 interacted with mitogen-activated protein kinase SlMPK8 Solanum lycopersicum
downstream signaling responses include MAPK activation
(ANQ1, ATMKK6, MKK6, SUMM4, AT5G56580) phosphorylates (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
summ4-1D mekk1-1 double mutant has similar dwarf morphology as mekk1-1 mutant Arabidopsis thaliana
MKKs phosphorylate MAPKs
Tandem zinc finger protein 9 (AtC3H66, TZF9, AT5G58620) is phosphorylated by mitogen-activated protein kinase 3 (ATMAPK3, ATMPK3, MPK3, AT3G45640)
pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) includes phosphorylation-dependent activation of three-tiered mitogen-activated protein kinase (MAPK) cascades
OsLRR-RLK1-silenced plants displayed decreased MAPK3/6 activation following SSB infestation Oryza sativa
phosphorylation intensity of MdMYB1 gradually decreased after 30 min of light exposure Malus domestica
MAPK cascade composed of (ATMEK4, ATMKK4, MKK4, AT1G51660) /5/9 and (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 can be activated stress conditions
(ATMEK4, ATMKK4, MKK4, AT1G51660) (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) function upstream of (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790)
reactive oxygen species (ROS) generation has an effective role in the regulation of mitogen-activated protein (MAP) kinase activities through their translocation from the cytosol to the nucleus Arabidopsis thaliana
(ATMKK7, BUD1, MKK7, AT1G18350) functions upstream of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790)
(ATMKK9, MKK9, AT1G73500) functions upstream of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
phosphorylation of (ATOST1, OST1, P44, SNRK2-6, SNRK2.6, SRK2E, AT4G33950) /42 MAPK (Erk1/2) increases >1.5-fold after 60 min of light treatment compared with baseline phosphorylation at 0 min Malus domestica
light treatment leads to rapid phosphorylation of MdMPK6 Malus domestica
proteins at the cell periphery of stomatal lineage cells modulate mitogen-activated protein kinase (MAPK) signalling directly by activating mitogen-activated protein kinase (MAPK) signalling Arabidopsis thaliana
low phosphate treatment activated (ATMAPK3, ATMPK3, MPK3, AT3G45640)
(ATPHOS32, PHOS32, AT5G54430) is substrate of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
current paradigm of MAPK signaling proposes that fewer MKKs regulate all MPKs
Tandem zinc finger protein 9 (AtC3H66, TZF9, AT5G58620) is phosphorylated by mitogen-activated protein kinase 6 (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790)
polyclonal antibodies raised against phosphorylated human ERK1 (Extracellular signal-Regulated Kinase 1) and ERK2 specifically react with activated form of plant ERK-related MAPKs
activation of mitogen-activated protein (MAP) kinase by oxidative stresses has also been reported for two members of the C1 subgroup of mitogen-activated protein (MAP) kinase in Arabidopsis, (ATMPK1, MPK1, AT1G10210) (ATMPK2, MPK2, AT1G59580) Arabidopsis thaliana
calcium and reactive oxygen species (ROS) are strong activators of MAPK signaling
(ATMEK4, ATMKK4, MKK4, AT1G51660) DD (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) DD expression does not alter transcription levels of (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) and (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
RAF–MEK–ERK pathways converge on Exo70 phosphorylation
genetic analysis of the MAPK pathway components in Arabidopsis revealed functionally redundant MKK–MPK network Arabidopsis thaliana
activated MAPKs phosphorylate substrate(s)
Arabidopsis tandem zinc finger 9 (AtC3H66, TZF9, AT5G58620) is phosphotarget of (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
activation of mitogen-activated protein (MAP) kinase in the cytosol is often assumed to result in translocation of MAP kinase to the nucleus
Phe-pre-treated flowers infected with Botrytis cinerea showed only few regulatory genes affected including those involved in MAP phosphorylation Chrysanthemum morifolium
(ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMPK4, MAPK4, MPK4, AT4G01370) are upstream factors of (ATEXO70A1, EXO70A1, AT5G03540) activation Arabidopsis thaliana
MdMYB1 expression increased in MdMPK4- and CA-MdMPK4-overexpressing calli Malus domestica
two MdMPK4 proteins have similar functions in increasing MdMYB1 stability Malus domestica
rapid response upon infection activates MAPKKK signaling events
group I WRKY transcription factors are activated by MAPK-dependent phosphorylation
(ATPHOS32, PHOS32, AT5G54430) is substrate of (ATMAPK3, ATMPK3, MPK3, AT3G45640) Arabidopsis thaliana
LRR proteins activate MAPK signaling events Chrysanthemum morifolium
phosphorylation of p38 increases in apple peels following light treatment Malus domestica
light treatment leads to rapid phosphorylation of MdMPK4 Malus domestica
phosphorylation intensity of MdMYB1 achieved highest level at 30 min after exposure to light Malus domestica
MEKK1-MKK1/MKK2-MPK4 MAP kinase cascade is studied extensively Arabidopsis thaliana
MdMPK6 highest level reached after 40 min of light treatment Malus domestica
mitogen-activated protein kinases (MAPKs) belong to MAPK cascades
phosphorylated MdMPK4 abundance increases after 15-min light treatment Malus domestica
48-kDa protein kinase is likely to be mitogen-activated protein kinase (MAPK) Nicotiana plumbaginifolia
MPK (MAPK) is activated by MPK kinase (MPKK or MEK)
(ATMAPK3, ATMPK3, MPK3, AT3G45640) is one of 20 MPKs present in Arabidopsis thaliana Arabidopsis thaliana
in vivo phosphorylation of MdMYB1 is mediated by MdMPK4 proteins under light conditions Malus domestica
MdMYB1 S142A phosphorylation greatly reduced when site was mutated Malus domestica
(ATMPK4, MAPK4, MPK4, AT4G01370) has been shown to be activated by hormones and by stress conditions hormones and stress conditions
extracellular signal-regulated kinase (ERK) is involved in cell proliferation and differentiation
(ATWRKY33, WRKY33, AT2G38470) is activated by phosphorylation through mitogen-activated protein kinases (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
functionally redundant MKK–MPK network converges on (ATEXO70A1, EXO70A1, AT5G03540) Arabidopsis thaliana
MdMPK6 initial activation observed after 10 min of light treatment Malus domestica
MAPK is required for H2O2 -induced increase in activity of NADPH oxidase Zea mays
minor MdMPK4 activity was detected under low-light conditions Malus domestica
G protein-coupled receptors (GPCRs) activate downstream mitogen-activated protein kinase pathway via heterotrimeric G proteins mitogen-activated protein kinase pathway
overexpression of MdMYB1 increased phosphorylation level of MdMYB1 through MdMPK4 Malus domestica
stronger phosphorylation of MdMYB1 compared to RNAi-MdMPK4 and wild-type lines Malus domestica
light treatment leads to rapid phosphorylation of MdMPK4 Malus domestica
chitosan treatment induces MAPK-mediated signal transduction Astragalus membranaceus
NaMKK1 silencing has no detectable effect on NaSIPK and NaWIPK activity Nicotiana attenuata
light treatment leads to rapid phosphorylation of MdMPK3 Malus domestica
MdMPK4 initial activation observed after 10 min of light treatment Malus domestica
wild-type calli treated with kinase inhibitor K252a caused significant decline in phospho-MdMPK4 and phospho-MdMYB1 levels Malus domestica
WIPK activity was only detected in W+OS-induced samples Nicotiana attenuata
treatment with phosphatase inhibitor okadaic acid (OA) caused obvious increase in phospho-MdMPK4 and phospho-MdMYB1 Malus domestica
MAPK activities might attend to regulate physiological responses in papilla cells in addition to (ATEXO70A1, EXO70A1, AT5G03540) localization Arabidopsis thaliana
(PAT1, AT5G48150) is phosphorylated by (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
SIPK and WIPK activity was determined in EV and NaGSNOR-VIGS plants 0, 10, 30, and 60 min after W+W and W+OS treatment Nicotiana attenuata
constitutively active form of NtMEK2 overexpression leads to activation of NtWIPK Nicotiana tabacum
NaBAK1 modulates wounding- and herbivory-induced JA levels either downstream of or independent of mitogen-activated protein kinase (MAPK) signalling Nicotiana attenuata
phosphorylation of MdMYB1 is mediated by MAPK cascade Malus domestica
MdMPK4-06G transcript levels were significantly higher than MdMPK4-14G following light treatment Malus domestica
stronger phosphorylation of MdMYB1 was observed in MdMPK4-, CA-MdMPK4s- and MdMYB1-overexpressing calli Malus domestica
OGs elicit (ATMAPK3, ATMPK3, MPK3, AT3G45640) activation Arabidopsis thaliana
NaMEK2 is important for simulated herbivory-elicited activation of salicylic acid-induced protein kinase (SIPK) Nicotiana attenuata
flg22 maximally activates less rapidly and less transiently than (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
mitogen-activated protein kinase (MAPK) cascade is involved in abiotic stress responses
three MAPKs ( (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) and (ATMPK4, MAPK4, MPK4, AT4G01370) ) have nuclear targets including (AtEIN3, EIN3, AT3G20770) Arabidopsis thaliana
acclimation-induced cross-tolerance is associated with activation of (ATMPK1, MPK1, AT1G10210) /2 Solanum lycopersicum
MdMPK4-06G expression levels decreased after highest expression level was detected at 30 min Malus domestica
(ATMKK9, MKK9, AT1G73500) overexpression activates (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
activated MAPK can phosphorylate cytoskeleton-associated proteins
wounding and simulated herbivory treatment rapidly enhances NaSIPK and NaWIPK activity Nicotiana attenuata
NaMEK2 is important for activation of NaSIPK Nicotiana attenuata
drought acclimation (DA) failed to induce (ATMPK1, MPK1, AT1G10210) /2 activation in pTRV-RBOH1 plants Solanum lycopersicum
MAPKKKs have not yet been described in canola Brassica napus
mitogen-activated-protein-kinase signalling may target microtubule system
SIPK and WIPK are required for wounding- and herbivory-induced JA and ethylene biosynthesis Nicotiana attenuata
PtaRHE1 in PtaRHE1-overexpressing plants possibly acts upstream of WIPK in activation of WRKYs Nicotiana tabacum
NaMKK1 is not required for activation of NaSIPK and NaWIPK Nicotiana attenuata
WIPK is >2-fold induced in PtaRHE1-overexpressing plants Nicotiana tabacum
W+W and W+OS in EV plants rapidly activated SIPK Nicotiana attenuata
constitutively active form of NtMEK2 overexpression leads to activation of NtSIPK Nicotiana tabacum
light treatment influences phosphorylation of MdMYB1 Malus domestica
NtMEK2 is upstream kinase of SIPK and WIPK Nicotiana tabacum
NaMEK2 and certain other MAPKKs are required for activation of NaWIPK Nicotiana attenuata
phospho-MdMYB1 levels increased when MdMPK4 genes were overexpressed Malus domestica
high MdMPK4 expression increased accumulation of phospho-MdMPK4 and phospho-MdMYB1 Malus domestica
(ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) may activate salicylic acid-induced protein kinase (SIPK) Nicotiana benthamiana; Nicotiana tabacum
higher phospho-MdMYB1 levels were observed under high-light compared to low-light treatment Malus domestica
MdMPK4-14G may be functional supplement to MdMPK4-06G in phosphorylating target genes Malus domestica
PD98059 pre-treatment shows no significant difference in Trx h3 expression Arabidopsis thaliana
acclimation induced activation of (ATMPK1, MPK1, AT1G10210) /2 Solanum lycopersicum
SIPK (Stress-Induced Protein Kinase) remains fully active in response to NO transgenic tobacco cell suspensions unable to accumulate salicylic acid (SA) Nicotiana tabacum
(ATMEK4, ATMKK4, MKK4, AT1G51660) and (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) activate (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
NaMKK1-VIGS plants have reduced NaMKK1 transcript levels Nicotiana attenuata
empty vector (EV) and NaBAK1-VIGS plants have similar levels of mitogen-activated protein kinase (MAPK) activity Nicotiana attenuata
three MAPKs ( (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) and (ATMPK4, MAPK4, MPK4, AT4G01370) ) have nuclear targets including (ERF104, AT5G61600) Arabidopsis thaliana
BnaRaf28 interacted with BnaMKK2 in epidermal cells of N. benthamiana Nicotiana benthamiana
activation of WIPK appeared to be delayed in response to GSH and GSSG
(AtRAV1, EDF4, RAV1, AT1G13260) may be negatively controlled by (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
Tyr-phosphorylated peptide corresponds to either mitogen-activated protein kinase (MAPK) (ATMPK8, MPK8, AT1G18150) or its close homolog (ATMPK15, MPK15, AT1G73670) Arabidopsis thaliana
overexpressing MAPKKKα can result in pathogen-independent cell death
calcium (Ca2+) has key role in NO-stimulated MAPK activation
MAPK kinase (MAPKK) and MAPKK kinase (MAPKKK) constitute functionally interlinked MAPK cascade
SIMK kinase (SIMKK) is identified as upstream activator of SIMK Medicago sativa
MKK–MPK–WRKY cascades demonstrated interesting phenotypes of gain- and loss-of-function plants in canola Brassica napus
carbon monoxide (CO) inhibits extracellular signal-regulated kinase (ERK) phosphorylation induced by wounding Ipomoea batatas
IbMAPK interacts with IbMEK1 Ipomoea batatas
BiFC, co-immunoprecipitation, and (ATGSTU24, GST, GSTU24, AT1G17170) pull-down assays identified interaction between IbMEK1 and IbMAPK
carbon monoxide (CO) might prevent IbMAPK from IbMEK1 activation
SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3 BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 ( (ATBAK1, ATSERK3, BAK1, ELG, RKS10, SERK3, AT4G33430) ) is implicated in the activation of mitogen-activated protein kinase 3 (ATMAPK3, ATMPK3, MPK3, AT3G45640) Arabidopsis thaliana
mitogen-activated protein kinases (MAPKs) play crucial role in plant growth and development
carbon monoxide (CO) alters phosphorylation of p38 mitogen-activated protein kinases (MAPK)
MAPK cascades consist of MAPK kinase kinase (MAPKKK), MAPK kinase (MAPKK), and MAPK
phosphorylation of IbMAPK was also inhibited by carbon monoxide (CO)
NTF6 kinase expression was barely affected in HGLs
three-tiered modules composed of Ser/Thr MAPK
MAPK cascades are major pathways to drive extracellular stimuli to multiple intercellular responses
NEM pre-treatment blocked activation of SIPK and WIPK by GSSG
ScFRK1 (fertilization-related kinase) is MAPKKK from the pMEKK subfamily Solanum chacoense
NO-induced 48-kDa MAPK is immunoprecipitated by anti-SIPK polyclonal antibodies Nicotiana plumbaginifolia
convergence of calcium (Ca2+) and nitric oxide (NO) signaling pathways might occur at MAPK level
nitric oxide (NO) activates mitogen-activated protein kinases (MAPKs) Nicotiana plumbaginifolia
mitogen-activated protein cascade ( (ARAKIN, ATMEKK1, MAPKKK8, MEKK1, AT4G08500) (ATMEK4, ATMKK4, MKK4, AT1G51660) /5, and (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6) specifically regulates transcription of (AtWRKY22, WRKY22, AT4G01250) Arabidopsis thaliana
MEK2 may activate salicylic acid-induced protein kinase (SIPK) Nicotiana benthamiana; Nicotiana tabacum
induction of WRKY factors and defence genes is observed during activation of tobacco MAPK cascade Nicotiana tabacum
(PHS1, AT5G23720) interacts with Arabidopsis MAPK18 Arabidopsis thaliana
FRAP assay can be used to measure MAPK signaling activity Arabidopsis thaliana
H2O2 -induced increase in activity of NADPH oxidase is substantially reduced by pretreatments with MAPKK inhibitors PD98059 and U0126 Zea mays
SA-induced protein kinase activity shows no differences between wild-type and ir-pme lines Nicotiana attenuata
phase II increase in expression of ZmrbohA–D induced by ABA requires MAPK activation Zea mays
MKK phosphorylation by canonical MKKKs activates MKKs
ubiquitin-specific protease 15 (UBP15, AT1G17110) regulates by modulating deubiquitination of Gpmk1 Fusarium graminearum
(NZZ, SPL, AT4G27330) expression was unaffected in (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) knockouts Arabidopsis thaliana
VIGS-MAP2K4 and VIGS-MAP2K2/MAP2K4 plants did not result in MAPK activation upon B. cinerea infection Solanum lycopersicum
mitogen-activated protein kinase (MAPK) cascade is involved in biotic stress responses
MAPK pathways are organized into three-tiered modules
MAPKKK genes have been reported in Arabidopsis thaliana and other plant species Arabidopsis thaliana
HglS display increased levels of phosphorylated (i.e. active state) SIPK
SlMAP3K18 physically interacted with SlMAP2K2 and SlMAP2K4 Solanum lycopersicum
subfamily C1 Raf-like kinase RAF27 (also known as BLUE LIGHT-DEPENDENT H+-ATPASE PHOSPHORYLATION; (BHP, AT4G18950) or INTEGRIN-LIKE KINASE 5; ILK5) associates with and phosphorylates (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220)
mitogen-activated protein kinase (MAPK) cascades contain mitogen-activated protein kinase kinases (MAP2Ks)
subfamily B3 Raf-like kinase MKKK δ-1 (M3Kdelta1, MKD1, RAF3, AT5G11850) can trans-phosphorylate (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) and (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220)
(PGN, AT1G56570) induced MAPK phosphorylation Oryza sativa
(M3Kdelta6, SIS8, AT1G73660) AT6 is predicted to encode putative MAPKKK Arabidopsis thaliana
PA species 16:0/18:2 activation of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) regulates downstream pathways
BnaMKK1 and BnaMKK4 did not interact with any of the 28 BnaMAPKKK proteins assayed Brassica napus
relative activation levels of SIPK and WIPK showed slightly different kinetics in response to GSH and GSSG
six BnaMKK proteins were found to interact with at least one BnaMAPKKK protein Brassica napus
BnaRaf28 interacted with BnaMKK6 in epidermal cells of N. benthamiana Nicotiana benthamiana
HglS display increased levels of phosphorylated WIPK, albeit to a lesser extent
PD98059 (MAPK cascade inhibitor) inhibits MAPK cascade activation Arabidopsis thaliana
fast and strong activation of SIPK and WIPK was observed in response to reduced and oxidized glutathione, respectively
mitogen-activated protein kinase (MAPK) superfamily has >100 members in Arabidopsis and rice Arabidopsis thaliana; Oryza sativa
(ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) regulate MAPK activities through an indirect mechanism that may involve upstream kinases or phosphatases Arabidopsis thaliana
Tomato (ATMPK1, MPK1, AT1G10210) /2 are orthologues of Arabidopsis (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Solanum lycopersicum; Arabidopsis thaliana
MAPK kinase kinase (MAPKKK) activates dual-specificity Ser/Thr and Tyr MAPK kinase (MAPKK)
regulation and function of subcellular localization of MAPK pathways is lacking in plants
carbon monoxide (CO) alters phosphorylation of extracellular signal-regulated kinases (ERK)
SIPK expression was barely affected in HGLs
adapted pathovar Pst induced less activation of both kinases
(AtbZIP67, DPBF2, AT3G44460) was found in protein microarrays as putative (ATMPK4, MAPK4, MPK4, AT4G01370) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) substrates Arabidopsis thaliana
(ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMPK4, MAPK4, MPK4, AT4G01370) double mutant showed flg22-induced MAPK activities that resembled (ATMAPK3, ATMPK3, MPK3, AT3G45640) single mutant Arabidopsis thaliana
MAP kinase dynamics has been better studied in budding yeast Saccharomyces cerevisiae
wild type and constitutively active versions of (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMPK4, MAPK4, MPK4, AT4G01370) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) could directly phosphorylate kinase-dead versions of (ATMAPK3, ATMPK3, MPK3, AT3G45640) or (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
(ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) activity prevention then blocks its downstream activity
NEM pre-treatment prevented activation of both MAPKs by flagellin
SIPK activation following GSSG treatment was maintained somewhat longer compared with WIPK activation
Arabidopsis plants overexpressing SIMKK have higher activity levels of (ATMAPK3, ATMPK3, MPK3, AT3G45640) Arabidopsis thaliana
(ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) MAPK cascade has possible upstream MAPKK kinases (MAPKKKs) (ARAKIN, ATMEKK1, MAPKKK8, MEKK1, AT4G08500) and ortholog(s) of tomato MAPKKKα Arabidopsis thaliana
Arabidopsis plants overexpressing SIMKK have higher activity levels of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
WRKY transcription factor genes were systemically studied and characterized in canola Brassica napus
antioxidant enzyme activity increase decreases phosphorylation of extracellular signal-regulated kinase (ERK)
Arabidopsis thaliana contains about 60 predicted MAPK kinase kinases (MAPKKKs) Arabidopsis thaliana
(ATPHOS32, PHOS32, AT5G54430) and (ATPHOS34, PHOS34, USP21, AT4G27320) are known targets of MAPK (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
activation of MAPK signalling in WT was particularly strong with non-adapted pathovar Psm
Arabidopsis thaliana contains 10 MAPK kinases (MAPKKs) Arabidopsis thaliana
NlMLP-triggered cell death is associated with MEK2-dependent MAPK cascades
MAPK cascades transduce extracellular stimuli into intracellular responses
MAPK cascade components activation of ToxA treatment
plant MAPK pathways regulate responses to pathogen attack Arabidopsis thaliana
(ATMAPK3, ATMPK3, MPK3, AT3G45640) mutant showed higher and longer activation of (ATMPK4, MAPK4, MPK4, AT4G01370) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) in response to flg22 treatment Arabidopsis thaliana
co-localization of BnaMAPKKK–BnaMKK interaction pairs facilitates their interaction and phosphorylation to mediate timely responses to external and internal stimuli Brassica napus
drought signal transmitted through identified Hog1-MAPK cascade in Rhizophagus irregularis Rhizophagus irregularis; Medicago truncatula
RAF27/ (BHP, AT4G18950) /ILK5 phosphorylates (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) at the consensus motif as well as at other sites
serine 366 and serine 503 on AtRAF15 showed opposing changes in phosphorylation state Arabidopsis thaliana
in vitro kinase assays were conducted to test whether BOR could be phosphorylated by MAPK Arabidopsis thaliana
elevated mobility of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) in the SLGC results from concentrated accumulation of upstream MAPKKK (EMB71, MAPKKK4, YDA, AT1G63700) and (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 at the (BASL, AT5G60880) polarity site Arabidopsis thaliana
MAPKs are Ser/Thr-specific protein kinases
putative MAPKKKs constitute most complex and largest group of MAPK pathway components
MEKK1-dependent (ATMPK4, MAPK4, MPK4, AT4G01370) responses are regulated independently of (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) and (ATMKK2, MK1, MKK2, AT4G29810)
(ATMAPK3, ATMPK3, MPK3, AT3G45640) regulates (ATMPK4, MAPK4, MPK4, AT4G01370) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) activities Arabidopsis thaliana
wild type and constitutively active MAPK proteins displayed autophosphorylation Arabidopsis thaliana
dual phosphorylation of (ATMPK8, MPK8, AT1G18150) or (ATMPK15, MPK15, AT1G73670) in Arabidopsis pollen Arabidopsis thaliana
MAPK signaling cascades active in Arabidopsis pollen Arabidopsis thaliana
MKK9–MPK6 cascade regulates leaf senescence Arabidopsis thaliana
NahG transgenic plants can reduce protein levels of (ATMAPK3, ATMPK3, MPK3, AT3G45640) Arabidopsis thaliana
H2O2 at the apoplast is essential for activation of (ATMPK1, MPK1, AT1G10210) /2 Solanum lycopersicum
(ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) are activated in response to same signals as (ARAKIN, ATMEKK1, MAPKKK8, MEKK1, AT4G08500) (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
wounding induces ERK phosphorylation Ipomoea batatas
MAPK18 belongs to D group MAPKs Arabidopsis thaliana
specific scaffold proteins generate a signaling conduit by assembling discrete set of signaling proteins into a complex
HopF2 targets MAPK kinase 5 (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) Arabidopsis thaliana
absence of one MAPK could influence function of the other MAPKs Arabidopsis thaliana
TDY motif thought to be phosphorylated by MAPKKs
crispr_nrpm mutants show reduced (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 activity levels Arabidopsis thaliana
HopF2 does not affect (ATMPK4, MAPK4, MPK4, AT4G01370) activation by (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) /2 Arabidopsis thaliana
(ATMAP65-1, MAP65-1, AT5G55230) interacts with (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
mitogen-activated protein kinase cascades play important roles in plant growth, development and stress responses
MAPKs suppress (SPCH, AT5G53210) proteins Arabidopsis thaliana
GmHSP40.1 overexpression engages hierarchical and specific MAPK signaling modules culminating in cell death Nicotiana benthamiana
Arabidopsis (AOD13, ATMKP1, MKP1, AT3G55270) is important regulator of (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
MAPKKKs could modulate downstream substrates with varying kinetic activity over time downstream substrates Arabidopsis thaliana
(EPF2, AT1G34245) activates MAPK cascade Arabidopsis thaliana
MAPKKs phosphorylate MAPKs
phosphopeptide for MAP3Kε2 ( (MAP3KE2, MAPKKK6, AT3G07980) ) identified MAP3Kε2 (MAP3KE2, MAPKKK6, AT3G07980) Arabidopsis thaliana
(ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) (ANQ1, ATMKK6, MKK6, SUMM4, AT5G56580) (ATMKK7, BUD1, MKK7, AT1G18350) and (ATMKK9, MKK9, AT1G73500) were able to phosphorylate (ATMPK12, MAPK12, MPK12, AT2G46070) in vitro
OsMKP1 physically interacts with OsMAPK6 Oryza sativa
MAPK Fus3p nuclear recovery is independent of pheromone treatment Saccharomyces cerevisiae
paraquat acclimation (PA) induced (ATMPK1, MPK1, AT1G10210) /2 activation in pTRV plants Solanum lycopersicum
SIMKK–YFP overexpression results in enhanced (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) kinase activation Arabidopsis thaliana
(BASL, AT5G60880) is MAPK scaffold protein Arabidopsis thaliana
MAP3Kε2 (MAP3KE2, MAPKKK6, AT3G07980) functionally redundant with MAP3Kε1 (MAP3KE1, MAPKKK7, AT3G13530) Arabidopsis thaliana
eight MKKs (MKK1-6, 7, and 9) have ability to interact or activate (ATMAPK3, ATMPK3, MPK3, AT3G45640) or (ATMPK4, MAPK4, MPK4, AT4G01370) or both Arabidopsis thaliana
orthologs of (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) in parsley cells are regulated by reactive oxygen species (ROS) generation through their translocation from the cytosol to the nucleus Petroselinum crispum
(ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) could also be activated in nucleus by a (ATMKK9, MKK9, AT1G73500) a nuclear-located mitogen-activated protein (MAP) kinase kinase Arabidopsis thaliana
phosphorylation of MAPK substrates with specific spatiotemporal expression patterns is a key approach to achieve (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) functional specificity
Exo70 in mammalian cells is phosphorylated by ERK1/2
MK2 is downstream target of p38 MAPK
wild-type protoplasts treated with flg22 and elf26 stimulated MAPK activity Arabidopsis thaliana
ascaroside #18 (Ascr18) induces activation of mitogen-activated protein kinase 6 (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
RiHog1 directly interacts with downstream key transcription factor RiMsn2 Rhizophagus irregularis
rice subfamily C2 Raf-like kinase OsILA1 phosphorylates OsMKK4 on multiple N-terminal residues including the key site Thr34 Oryza sativa
mitogen-activated protein kinases (MAPKs) (ATMPK4, MAPK4, MPK4, AT4G01370) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) are involved in regulating stress hormone levels Arabidopsis thaliana
signalling network exhibits high level of complexity
phosphorylation cascade is usually composed of MAP KINASE KINASE KINASEs (MAPKKK/MAP3K/MEKK/MKKK), MAP KINASE KINASES (MAPKK/MKK/MEK), and MAP KINASES (MAPK/MPK)
Slferl mutants showed MAPK activity at slightly higher level than WT upon B. cinerea infection Solanum lycopersicum
MEKK1-MKK1/2-MPK4 cascade is involved in defense responses Arabidopsis thaliana
YODA is specified as MEKK-like MAPKKK Arabidopsis thaliana
(ATWRKY33, WRKY33, AT2G38470) interacts with MAP kinase substrate (MKS1, AT3G18690) Arabidopsis thaliana
B. cinerea infection activated MAPK pathway Solanum lycopersicum
S/TP motif fits MAPK phosphorylation preferences is reasonable to speculate MAPK activation is required for (PAP3, PIF3, POC1, AT1G09530) phosphorylation induced by flg22 Arabidopsis thaliana
Arabidopsis (ATRBOHD, DELT1, RBOHD, AT5G47910) mutant did not affect activation of (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
penetration is controlled by Ste11-Ste7-Gpmk1 mitogen-activated protein kinase (MAPK) pathway Fusarium graminearum
SlMPK3 is significantly upregulated in peptide 1-treated leaves during 30 min to 6 h of treatment Solanum lycopersicum
SlFERL (Solanum lycopersicum FERONIA Like) phosphorylates at Thr45, Ser49, Ser76, and Ser135 SlMAP3K18 Solanum lycopersicum
S/TP dipeptide motifs have been reported as possible MAPK phosphorylation sites
MAPK activation induced by flg22 was comparable in (PAP3, PIF3, POC1, AT1G09530) mutants, -OX and WT plants Arabidopsis thaliana
flg22-induced (PAP3, PIF3, POC1, AT1G09530) phosphorylation is dependent on (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 activation Arabidopsis thaliana
Raf-like kinase phosphorylation of MKKs there is limited evidence that this phosphorylation occurs within S/T-X3-5-S/T motif
bona fide role of Raf-like kinases as MKKKs has been debated
WRKY transcription factors are known MAPK substrates Arabidopsis thaliana
MAPKs regulate various intracellular effectors
SlFERL-SlMAP3K18 (S. lycopersicum mitogen associated protein kinase kinase kinase 18) module functioned in modulating protein levels and/or kinase activities of SlMAP2K4 Solanum lycopersicum
both (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) may phosphorylate (PAP3, PIF3, POC1, AT1G09530) Arabidopsis thaliana
mitogen-activated protein kinase (MAPK) cascades is conserved and vital signal pathway
in-gel kinase assays with stigmatic proteins from SLR1 :: MPK4Ri plants validated identity of third kinase as (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
activated MKKs phosphorylate MAPK targets
mitogen-activated protein kinase (MAPK) cascades relay and amplify environmental signals
(ATEDR1, EDR1, AT1G08720) mutants accumulate less (ATMEK4, ATMKK4, MKK4, AT1G51660) (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) (ATMAPK3, ATMPK3, MPK3, AT3G45640) proteins
(ATEDR1, EDR1, AT1G08720) acts as noncanonical MKKK
BASL_12356A mutant abrogates phosphorylation by (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6
doxycycline (Dox) exposure induces concerted increase of MITOGEN-ACTIVATED PROTEIN KINASE 6 (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) phosphorylation Arabidopsis thaliana
MAPK kinase kinase (MAPKKK) family is divided into MEKK-like and Raf-like kinases
SlMAP2K4 DD (Thr216 and Ser222 mutated to Asp216 and Asp222) is phosphor-mimic constitutive activation form of MAP2K4 Solanum lycopersicum
(M3Kdelta1, MKD1, RAF3, AT5G11850) additionally phosphorylates (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) at Thr83 and (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) at Ser46
AvrAC can also inhibit flg22-triggered MAPK activation Arabidopsis thaliana
SlFERL-KD (intracellular domain of SlFERL, 467–889 aa) interacted with Raf-like mitogen-associated protein kinase kinase kinase 18 (SlMAP3K18) Solanum lycopersicum
SlFERL interacted with SlMAP3K18 Solanum lycopersicum
(ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) DD is constitutive active form of (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) Arabidopsis thaliana
activation of (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) by (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) DD is sufficient to induce (PAP3, PIF3, POC1, AT1G09530) phosphorylation in the absence of PAMPs Arabidopsis thaliana
SlMAP3K18 functional redundancy may explain lack of distinct phenotype in VIGS-SlMAP3K18 Solanum lycopersicum
(NZZ, SPL, AT4G27330) is phosphorylated by MITOGEN-ACTIVATED PROTEIN KINASEs (MPKs) (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 Arabidopsis thaliana
protein tyrosine phosphatases (PTPs) major functional theme is the regulation of signaling by mitogen-activated protein kinase (MAPK)
SlFERL-SlMAP3K18 module substantially modulated protein level and/or kinase activity of SlMAP2K2/SlMAP2K4 Solanum lycopersicum
(ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) DD can activate (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
SlMPK3 is significantly upregulated in Bg_9562 protein-treated leaves during 30 min to 6 h of treatment Solanum lycopersicum
Raf-like kinases are considered a subfamily of MKKKs
calcium/calmodulin-regulated receptor-like kinase 1 (CRLK1, AT5G54590) interacts with (ARAKIN, ATMEKK1, MAPKKK8, MEKK1, AT4G08500)
constitutively activated (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) DD negatively regulates plant freezing tolerance Arabidopsis thaliana
MAPKKKs phosphorylate and activate specific MAPKKs
ROS are known to activate (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMPK4, MAPK4, MPK4, AT4G01370) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790)
ubiquitin-specific protease 15 (UBP15, AT1G17110) modulates deubiquitination of mitogen-activated protein kinase Gpmk1 Fusarium graminearum
certain Raf-like kinases may operate as canonical MKKKs
UV-damaged DNA is a trigger of MAPK signaling Arabidopsis thaliana
MAPKK–MAPK cascade may act downstream of (M3Kdelta6, SIS8, AT1G73660) Arabidopsis thaliana
MAPK kinases (MAP2Ks, MKKs or MEKs) are activated by MAPK kinase kinases (MAP3Ks or MEKKs)
EPF/EPFL peptides except (AtEPFL9, EPFL9, STOMAGEN, AT4G12970) activates downstream MAPK cascade Arabidopsis thaliana
MAPKKKα and WIPK are required for HSP40-activated cell death
MAPKKKs are involved in cell division Arabidopsis thaliana
MAPK18 and possibly other MAPKs may activate tubulin kinase domain of (PHS1, AT5G23720)
ascaroside #18 (Ascr18) induces activation of mitogen-activated protein kinase 3 (ATMAPK3, ATMPK3, MPK3, AT3G45640) Arabidopsis thaliana
(ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) regulates (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMPK4, MAPK4, MPK4, AT4G01370) activities Arabidopsis thaliana
TDY dual phosphorylation motif is recognized by mitogen-activated protein kinase (ATMPK15, MPK15, AT1G73670) Arabidopsis thaliana
plant MAPK pathways regulate responses to abiotic stress Arabidopsis thaliana
MAPKKKs are involved in stomatal development Arabidopsis thaliana
phosphorylation at three sites on M3KE1 increased significantly upon boron deprivation Arabidopsis thaliana
activation of MAPK cascades may serve as means of coherent, nutrient limitation induced phosphorylation of downstream targets Arabidopsis thaliana
(AOD13, ATMKP1, MKP1, AT3G55270) negatively regulates MAPK signaling Arabidopsis thaliana
mitogen-activated protein kinase (MAPK) cascades are conserved signaling pathways found in yeast, humans and plants
(AOD13, ATMKP1, MKP1, AT3G55270) knockout mutants is associated with reduced inactivation of MAP kinases (MAPKs) (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
(BASL, AT5G60880) through its MAPK clients simultaneously enhances SPEECHLESS (SPCH) degradation in stomatal lineage ground cells (SLGCs) and protects SPCH in meristemoids through depleting MAPK abundance in meristemoid SPEECHLESS (SPCH, AT5G53210) levels in meristemoids and stomatal lineage ground cells (SLGCs)
NtMPK4 is ortholog of (ATMPK4, MAPK4, MPK4, AT4G01370) Nicotiana tabacum; Arabidopsis thaliana
Oxidative Signal-Inducible 1 (AGC2, AGC2-1, AtOXI1, OXI1, AT3G25250) expression leads to activation of (ATMAPK3, ATMPK3, MPK3, AT3G45640) Arabidopsis thaliana
(ATMPK8, MPK8, AT1G18150) is one of Arabidopsis MAPKs Arabidopsis thaliana
RBOH expression is finely tuned both positively and negatively by MAPK cascades Arabidopsis thaliana
intensities of all phosphopeptides assigned to the three MPKs were found to be decreased under long time deprivation of boron Arabidopsis thaliana
mitogen-activated protein kinases (MAPKs) result in wide range of intracellular responses Arabidopsis thaliana
cold acclimation (CA) failed to induce (ATMPK1, MPK1, AT1G10210) /2 activation in pTRV-RBOH1 plants Solanum lycopersicum
paraquat acclimation (PA) failed to induce (ATMPK1, MPK1, AT1G10210) /2 activation in pTRV-RBOH1 plants Solanum lycopersicum
three-tiered modules composed of MAPK kinase kinase (MAPKKK)
MAPKKKs interact with BnaMKKs Brassica napus
BnaMKK1 and BnaMKK4 may be transducer signals from other upstream MAPKKK proteins Brassica napus
(BASL, AT5G60880) scaffolds mitogen-activated protein kinase (MAPK) signaling components
links of different MAPK cascades to specific downstream gene activation remain unclear at the moment Arabidopsis thaliana
TDY-type MAPKs form the largest subgroup in rice Oryza sativa
ABSCISIC ACID INSENSITIVE 4 (ABI4, ATABI4, GIN6, ISI3, SAN5, SIS5, SUN6, AT2G40220) could directly control MAPK cascade Arabidopsis thaliana
MAPK signaling cascades is an early immune response activated by chitin in rice Oryza sativa
OsCERK1 is required for PGN- and chitin-induced MAPK activation Oryza sativa
(M3Kdelta6, SIS8, AT1G73660) is annotated as MAPKKK Arabidopsis thaliana
ROS burst is not required for activation of tobacco SIPK/WIPK Nicotiana tabacum
WIPK acts in a MAPKKKα-independent module in Pto/AvrPto-triggered cell death
hydroxyurea does not activate MAP kinases (MAPKs) (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
(ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) phosphorylates BASL at S89, S145, S168, S235, and S246 phosphosites of (BASL, AT5G60880)
(ATMKK3, MKK3, AT5G40440) and CaMs may have interactive roles for (ATMPK8, MPK8, AT1G18150) signaling Arabidopsis thaliana
SlFERL-SlMAP3K18 (S. lycopersicum mitogen associated protein kinase kinase kinase 18) module functioned in modulating protein levels and/or kinase activities of SlMAP2K2 (S. lycopersicum mitogen associated protein kinase kinase 2) Solanum lycopersicum
mitogen-activated protein kinase (MAPK) cascades contain mitogen-activated protein kinase kinase kinases (MAP3Ks)
tubulin kinase domain is embedded within negatively acting MAPK phosphatase molecule
mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules
MAPK substrates provide insights into regulatory mechanism of MAPK
kinetic values of interactions between MdMPK4-06G-MdMYB1 and MdMPK4-14G-MdMYB1 showed no significant differences between the two MdMPK4 proteins Malus domestica
(ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) may be activated by exogenously added H2O2 Arabidopsis thaliana
SUB1A is MPK phosphorylation target Oryza sativa
Arabidopsis (ATMEK4, ATMKK4, MKK4, AT1G51660) (ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP2K_A, MEK5, MKK5, AT3G21220) and (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) function in regulating development and defense against pathogens Arabidopsis thaliana
(ANP2, MAPKKK2, NP2, AT1G54960) (ANP3, AtANP3, MAPKKK12, NP3, AT3G06030) CA-MPK4 triple mutant partially suppresses dwarf morphology of anp2-2 anp3-3 double mutant Arabidopsis thaliana
MAPK cascades in plants have been identified in signal transduction
(ARAKIN, ATMEKK1, MAPKKK8, MEKK1, AT4G08500) functions on other as yet unknown pathways
MAPKKKs phosphorylate MKKs
(ATMPK1, MPK1, AT1G10210) (ATMAPK3, ATMPK3, MPK3, AT3G45640) (ATMPK4, MAPK4, MPK4, AT4G01370) (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) (ATMPK11, MPK11, AT1G01560) and MPK13 are flg22-responsive MAPKs
(AtC3H66, TZF9, AT5G58620) also acts upstream of MAPKs
MdMPK4-06G expression levels increased after 5 min of light exposure Malus domestica
MAPK cascades modulate environmental stress resistance
mitogen-activated protein kinase phosphatase 1 (OsMKP1) deactivates mitogen-activated protein kinase 6 (OsMAPK6) Oryza sativa
activity of OsMAPK6 was increased in osmkp1 mutant Oryza sativa
MAPK cascades in plants have been identified in disease resistance
MAPKs, MAPKKs, and MAPKKKs work in combinations to form distinct MAP kinase cascades Arabidopsis thaliana
activated MAPKs have downstream targets including cytoskeleton-associated proteins
(ANQ1, ATMKK6, MKK6, SUMM4, AT5G56580) interacted with (ATMPK4, MAPK4, MPK4, AT4G01370) Arabidopsis thaliana
MPK4-HA-YCE expressed in summ2-8 (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) /2 protoplasts is not activated upon treatment with flg22 Arabidopsis thaliana
20 transcription factors are regulated by (ARAKIN, ATMEKK1, MAPKKK8, MEKK1, AT4G08500)
(ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 activity is induced by mitochondrial signal upon oxygen deprivation Arabidopsis thaliana
MAPKKK-MKK cascades may be upstream of SlMPK1 negatively responding to heat stress signaling Solanum lycopersicum
functional redundancy at MKK tier breaks current paradigm of MAPK signaling Arabidopsis thaliana
LRR RLKs consequently trigger MAPKKK signaling events
ABSCISIC ACID INSENSITIVE 4 (ABI4, ATABI4, GIN6, ISI3, SAN5, SIS5, SUN6, AT2G40220) can be phosphorylated at multiple residues by mitogen-activated protein kinase 3 (ATMAPK3, ATMPK3, MPK3, AT3G45640)
MdMPK3 highest level reached after 40 min of light treatment Malus domestica
two distinct MdMPK4 proteins can interact with MdMYB1 Malus domestica
(ARAKIN, ATMEKK1, MAPKKK8, MEKK1, AT4G08500) /MKK1-MKK2/ (ATMPK4, MAPK4, MPK4, AT4G01370) module negatively regulates expression of (MAPKKK9, MEKK2, SUMM1, AT4G08480) Arabidopsis thaliana
Yoda-MKK4/MKK5-MPK3/ (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) MAP kinase cascade mediate signal transduction from upstream RLKs such as ERECTA and BRI1-ASSOCIATED KINASE1 (ATBAK1, ATSERK3, BAK1, ELG, RKS10, SERK3, AT4G33430) Arabidopsis thaliana
35S-MKK6-HA plasmid cotransformed with MPK4-HA-YCE construct in summ2-8 (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) /2 protoplasts results in activation of MPK4-HA-YCE upon flg22 treatment Arabidopsis thaliana
RACK1 functions as scaffold protein to bridge protein interactions in mitogen-activated protein kinase (MAPK) cascade-mediated signaling
AtLAZY/LZY phosphorylation by MPK is pivotal for gravity signaling Arabidopsis thaliana
microtubules are cytoskeletal targets of activated mitogen-activated protein kinase (MAPK)
(ATMKK9, MKK9, AT1G73500) might be upstream component of SlMPK1 in response to heat stress Solanum lycopersicum
flg22 treatment induces activation of phosphorylated (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
summ4-1D (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) /2 plants have phosphorylated MPKs detected at position of third band in flg22-treated MAPK activation Arabidopsis thaliana
de novo synthesis of short-lived phosphatases is known to be required for attenuation of MAPK phosphorylation Arabidopsis thaliana
functional yeast screen identified mutations that render Arabidopsis MAPKs constitutively active Arabidopsis thaliana
mitochondrial oxidative burst results in the activation of (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790)
ANPs (Arabidopsis NPR1-related protein kinases)-MKK6-MPK4 MAP kinase cascade is studied extensively Arabidopsis thaliana
increased expression of (ANQ1, ATMKK6, MKK6, SUMM4, AT5G56580) leads to restoration of (ATMPK4, MAPK4, MPK4, AT4G01370) activation by flg22 in summ4-1D (ATMEK1, MEK1, MKK1, NMAPKK, AT4G26070) /2 Arabidopsis thaliana
NaSERK3/ (ATBAK1, ATSERK3, BAK1, ELG, RKS10, SERK3, AT4G33430) silencing did not result in reduced MPK activity Nicotiana attenuata
MKPs specifically inactivate activated MAPKs
OsMKP1 dephosphorylates and deactivates OsMAPK6 Oryza sativa
multisite phosphorylation was detected for AtRAF15 Arabidopsis thaliana
OsILA1 phosphorylation of OsMKK4 not in consensus motif Oryza sativa
MEKK-like MKKKs play noncanonical roles in signaling pathways
cell death induced by NtMEK2 DD expression was fully suppressed in leaves silenced for SIPK
MAPK phosphatases (MKPs) catalyze dephosphorylation of phosphothreonine and phosphotyrosine in MAPK activation loops Arabidopsis thaliana
protein phosphorylation networks include mitogen-activated protein kinase (MAPK) cascades
OsMKP1 directly interacts with OsMAPK6 Oryza sativa
OsMKK4-OsMAPK6 module is involved in regulation of grain size Oryza sativa
MAPK activation was comparable between these transgenic plants Arabidopsis thaliana
canonical MKKKs phosphorylate MKKs at specific Ser/Thr residues located within a conserved S/T-X3-5-S/T motif
modulation of deubiquitination of mitogen-activated protein kinase Gpmk1 influences protein stability of Gpmk1 Fusarium graminearum
mutation of Thr215 and Ser221 in the S/T-X3-5-S/T motif to nonphosphorylatable Ala residues reduced trans-phosphorylation by RAF27/ (BHP, AT4G18950) /ILK5
sorghum has several TDY-type MAPKs Sorghum bicolor
MAPK cascades transfer signals through sequential phosphorylation and activation
MAPK cascade is composed of MAPK kinase kinase (MAPKKK), MAPK kinase (MAPKK) and MAPK
symrk-409 mutant plants show no attenuation of flg22-induced (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 phosphorylation after rhizobial inoculation Lotus japonicus
MAPK inhibition by AvrPto was diminished when AvrPto Y89D was used Arabidopsis thaliana
different enzymatic activity of MAPKKK isoforms and their substrates dependent on duration of boron deprivation may be attributed to different phosphorylation patterns of MAPKKKs Arabidopsis thaliana
MAP3Ks activation and connection to upstream sensors and receptors in plants is not yet understood
mitogen-activated protein kinase phosphatase 1 (OsMKP1) directly interacts with mitogen-activated protein kinase 6 (OsMAPK6) Oryza sativa
growth signals may activate OsMKK4 Oryza sativa
growth signals may activate OsMKK4 through upstream MAPK kinase kinase (MKKK) Oryza sativa
signaling promoting grain growth may activate OsMKK4 through upstream mitogen-activated protein kinase kinase (MKKK) Oryza sativa
Arabidopsis (AtWRKY22, WRKY22, AT4G01250) is induced by MAPK pathway Arabidopsis thaliana
flg22 elicit (ATMAPK3, ATMPK3, MPK3, AT3G45640) activation Arabidopsis thaliana
AMK1 encodes mitogen-activated protein kinase Alternaria brassicicola
MAPKKKs are involved in oxidative stress response Arabidopsis thaliana
MAPK signaling pathways are complex in regulating wounding- and herbivory-induced responses Nicotiana attenuata
NaMKK1 is closely related to (ATMKK7, BUD1, MKK7, AT1G18350) (ATMKK8, MKK8, AT3G06230) and (ATMKK9, MKK9, AT1G73500) Nicotiana attenuata
HME fraction strongly increased MAPK activity Oryza sativa
phosphorylation kinetics data demonstrate mitogen-activated protein kinase (MAPK) cascades Arabidopsis thaliana
oxidative burst observed in mitochondria during oxygen deprivation activates MPKs
MAPKKKs are serine or threonine kinases
Infection with B. cinerea caused induction of MAPKKK signaling events Botrytis cinerea
(AtCLA1, CLA, CLA1, DEF, DXPS2, DXS, DXS1, AT4G15560) domains mediate MAPK-interacting protein signaling efficiency and specificity
(BASL, AT5G60880) may function as MAPK scaffold protein
SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3 BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 ( (ATBAK1, ATSERK3, BAK1, ELG, RKS10, SERK3, AT4G33430) ) is implicated in the activation of mitogen-activated protein kinase 6 (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) Arabidopsis thaliana
Medicago sativa PP2C (MP2C) acts as negative regulator of MAPK pathways Medicago sativa
distinct MAP kinase cascades play diverse roles in plant development and stress signaling Arabidopsis thaliana
MAPK activities might attend to regulate physiological responses in papilla cells in addition to (ATEXO70A1, EXO70A1, AT5G03540) localization Arabidopsis thaliana
(PP4R3, PSY2L, SMEK1, AT3G06670) was identified as suppressor of MEK
tobacco NtMEK1–NTF6 is homolog of MKK6–MPK4 Nicotiana tabacum; Arabidopsis thaliana
(ATWRKY33, WRKY33, AT2G38470) couples kinase from (MKS1, AT3G18690)
activated (ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) are translocated to nucleus, where they regulate the expression of stress-regulated genes Arabidopsis thaliana
(ATMAPK3, ATMPK3, MPK3, AT3G45640) and (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) show activity in stage 12 stigmas Arabidopsis thaliana
Phe pre-treatment probably activates MAPK signaling events
SlMKK9 (Solyc03g097920) was identified to interact with SlMPK1 Solanum lycopersicum
flg22 treatment induces activation of phosphorylated (ATMAPK3, ATMPK3, MPK3, AT3G45640) Arabidopsis thaliana
MAPK cascade composed of (ATMEK4, ATMKK4, MKK4, AT1G51660) /5/9 and (ATMAPK3, ATMPK3, MPK3, AT3G45640) /6 phosphorylates (ACS2, AT-ACC2, AT1G01480) /6
CONSTITUTIVE TRIPLE RESPONSE 1 (AtCTR1, CTR1, SIS1, AT5G03730) is Raf-like MAPKKK (mitogen-activated protein kinase kinase kinase) family protein
(IDA, AT1G68765) signal involves MAPK cascades Solanum lycopersicum
(EMB71, MAPKKK4, YDA, AT1G63700) functions upstream of (ATMEK4, ATMKK4, MKK4, AT1G51660) /MKK5-MPK3/ (ATMAPK6, ATMPK6, MAPK6, MPK6, AT2G43790) module
phosphorylation of (ATOST1, OST1, P44, SNRK2-6, SNRK2.6, SRK2E, AT4G33950) /42 MAPK (Erk1/2) increases following light treatment Malus domestica
MAPK cascades regulate plant light responses