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iron homeostasis

15652 relationships annotated with this phrase. Showing first 500 of 15652.
Source entity Relationship Target entity Species
vacuolar Ascorbate transporter AtDTX25 promotes reduction and mobilization of Fe 3+ stored in vacuoles Arabidopsis thaliana
(HTB4, AT5G59910) pro-GUS/Col-0 seedlings shows enhanced GUS signals under Fe-deficient conditions Arabidopsis thaliana
Iron (Fe) plays a vital role in photosynthesis, respiration, hormone biosynthesis, morphogenesis, and cellular enzymatic reactions
(PYE, AT3G47640) interacts with clade IVc (bHLH, AT5G51780) ( (bHLH105, ILR3, AT5G54680) and (bHLH115, AT1G51070) ) Arabidopsis thaliana
unsuberized root zones where Fe 3+ reduction can occur are elongated in iron deficiency conditions
(BHLH038, bHLH38, ORG2, AT3G56970) is suppressed in (HTB4, AT5G59910) mutant
(HTB4, AT5G59910) comp plants under Fe deficiency conditions rescue (ATFRO2, FRD1, FRO2, AT1G01580) and (ATIRT1, IRT1, AT4G19690) induction Arabidopsis thaliana
(HTB4, AT5G59910) regulates expression of upstream (bHLH, AT5G51780) TFs Arabidopsis thaliana
FIT/bHLH29 (FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR; clade IIIa) interacts with (BHLH038, bHLH38, ORG2, AT3G56970) and (BHLH039, bHLH39, ORG3, AT3G56980) and (BHLH100, AT2G41240) and (BHLH101, AT5G04150) (clade Ib) Arabidopsis thaliana
clade Ib bHLHs ( (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) (BHLH101, AT5G04150) ) interact with FIT/bHLH29 (FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR; clade IIIa) Arabidopsis thaliana
(BTSL1, AT1G74770) (BRUTUS LIKE 1) and (BTSL2, AT1G18910) (BRUTUS LIKE 2) are involved in degradation of FIT Arabidopsis thaliana
genes with decreased expression in (HTB4, AT5G59910) mutant compared to wild-type plants include (FEP1, IMA3, AT2G30766) Arabidopsis thaliana
suppression of Ib (bHLH, AT5G51780) transcription factors compromises FERRIC REDUCTION OXIDASE 2 (ATFRO2, FRD1, FRO2, AT1G01580) expression
Arabidopsis has 17 different (bHLH, AT5G51780) proteins from six clades Arabidopsis thaliana
(HTB4, AT5G59910) promotes expression of FIT Arabidopsis thaliana
(HTB4, AT5G59910) promotes enrichment of active mark H3K4me3 near TSSs Arabidopsis thaliana
clade Ib (bHLH, AT5G51780) proteins heterodimerize with FIT Arabidopsis thaliana
(ARAPPT, CUE1, NOX1, PPT, AT5G33320) mutants have altered expression of (ATFER1, FER1, AT5G01600) and/or (ATFRO2, FRD1, FRO2, AT1G01580) Arabidopsis thaliana
(ATOPT3, OPT3, AT4G16370) (oligopeptide transporter) is upregulated in (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant Arabidopsis thaliana
(ATIREG2, FPN2, IREG2, AT5G03570) is not upregulated in germinating (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant Arabidopsis thaliana
(HTB4, AT5G59910) is associated with gene regulatory regions of Ib (bHLH, AT5G51780) TFs Arabidopsis thaliana
(ATOPT3, OPT3, AT4G16370) (oligo peptide transporter 3) is involved in communicating the shoot iron status to the root Arabidopsis thaliana
up-regulation of (S8H, AT3G12900) (ATFRO2, FRD1, FRO2, AT1G01580) (ATIRT1, IRT1, AT4G19690) etc is obviously sufficient to compensate for iron imbalances caused by defective suberin-like (SL) deposition Populus trichocarpa
(H2B, HTB2, AT5G22880) histone variant (HTB4, AT5G59910) binds to promoter regions of Ib subgroup basic helix–loop–helix (bHLH) transcription factors
(bHLH34, IDT1, AT3G23210) (iron deficiency tolerant 1) positively regulates expression of clade Ib bHLHs Arabidopsis thaliana
negative correlation between (HTB4, AT5G59910) and genes that encode proteins that negatively regulate clade Ib expression is proposed to exist between (HTB4, AT5G59910) and (PYE, AT3G47640) (BTS, EMB2454, AT3G18290) (BTSL1, AT1G74770) and (BTSL2, AT1G18910) Arabidopsis thaliana
Zea mays employs another iron uptake strategy Zea mays
(HTB4, AT5G59910) expression is repressed under iron sufficiency Arabidopsis thaliana
nia1nia2 mutants have altered expression of (ATFER1, FER1, AT5G01600) and/or (ATFRO2, FRD1, FRO2, AT1G01580) Arabidopsis thaliana
Ib (bHLH, AT5G51780) TFs (bHLH034, (bHLH104, AT4G14410) (bHLH105, ILR3, AT5G54680) , and (bHLH115, AT1G51070) ) and (bHLH121, URI, AT3G19860) regulate Ib (bHLH, AT5G51780) TFs during Fe deficiency Arabidopsis thaliana
(H2B, HTB2, AT5G22880) histone variant (HTB4, AT5G59910) enhances expression of Ib subgroup basic helix–loop–helix (bHLH) transcription factors
(HTB4, AT5G59910) comp plants rescue (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) expression decrease Arabidopsis thaliana
(HTB4, AT5G59910) is primarily enriched at transcriptional start sites (TSSs) of (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) Arabidopsis thaliana
(HTB4, AT5G59910) mutant impairs root iron uptake
full-length (BTS, EMB2454, AT3G18290) (BBG) complemented bts-1 lines by restoring iron reductase activity Arabidopsis thaliana
plants encounter iron-deficient conditions leads to (BTS, EMB2454, AT3G18290) accumulation Arabidopsis thaliana
(ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant triggers Fe deficiency response even in presence of Fe in the medium Arabidopsis thaliana
(ATNRAMP3, NRAMP3, AT2G23150) transcript levels are decreased in (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant Arabidopsis thaliana
mRNA levels are up-regulated under low-iron conditions Arabidopsis thaliana
(BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) expression are significantly suppressed in (HTB4, AT5G59910) mutant plants Arabidopsis thaliana
regulation of iron homeostasis is well-conserved in plants
(BHLH101, AT5G04150) is suppressed in (HTB4, AT5G59910) mutant
exogenous Fe application suppresses (HTB4, AT5G59910) expression Arabidopsis thaliana
(BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) gene expression are significantly downregulated in (HTB4, AT5G59910) mutant Arabidopsis thaliana
(bHLH, AT5G51780) TFs play important role in Fe deficiency response Arabidopsis thaliana
(H2B, HTB2, AT5G22880) histone variant (HTB4, AT5G59910) directly promotes expression of clade Ib bHLHs Arabidopsis thaliana
dicotyledonous plants generally employ iron strategy I to acquire iron from root medium
(HTB4, AT5G59910) pro-GUS/Col-0 seedlings shows decreased GUS signals under Fe-abundant conditions Arabidopsis thaliana
bHLH-IRT1 cascade is repressed by loss of function of (HTB4, AT5G59910) Arabidopsis thaliana
FIT/bHLH29 (FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR; clade IIIa) and (BHLH038, bHLH38, ORG2, AT3G56970) and (BHLH039, bHLH39, ORG3, AT3G56980) and (BHLH100, AT2G41240) and (BHLH101, AT5G04150) (clade Ib) form heterodimers with partially overlapping roles iron homeostasis regulation Arabidopsis thaliana
(ATNAS4, NAS4, AT1G56430) (NICOTIANAMINE SYNTHASE 4) expression is reduced in (HTB4, AT5G59910) mutants Arabidopsis thaliana
Arabidopsis shows iron deficiency-induced decreased suberization of roots Arabidopsis thaliana
(HTB4, AT5G59910) plays crucial role in maintaining Fe homeostasis Arabidopsis thaliana
(bHLH121, URI, AT3G19860) (UPSTREAM REGULATOR OF (ATIRT1, IRT1, AT4G19690) ) positively regulates expression of clade Ib bHLHs Arabidopsis thaliana
H3K4me3 active mark is enriched in promoter regions of (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) Arabidopsis thaliana
inducible overexpression of (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) or (BHLH101, AT5G04150) significantly increased Fe content of estradiol-treated transgenic plants Arabidopsis thaliana
severe leaf chlorosis could be rescued by exogenous application of Fe Arabidopsis thaliana
(ATNAS1, NAS1, AT5G04950) (nicotianamine synthase 1) expression is reduced in (HTB4, AT5G59910) mutants Arabidopsis thaliana
plant ferritins play important roles in binding excess iron to limit oxidative stress
35s::GSNOR1 mutants had AtFRO2 transcript levels different from Col-0 Arabidopsis thaliana
inducible overexpression of (ATIRT1, IRT1, AT4G19690) attenuated phenotype of (HTB4, AT5G59910) mutant Arabidopsis thaliana
genes with decreased expression in (HTB4, AT5G59910) mutant compared to wild-type plants include (bHLH34, IDT1, AT3G23210) (bHLH, AT5G51780) transcription factor Arabidopsis thaliana
(bHLH34, IDT1, AT3G23210) (bHLH, AT5G51780) transcription factor is a direct positive regulator of clade Ib bHLHs expression Arabidopsis thaliana
heavy metal transport protein might play a role in regulating Fe accumulation in nectar Melianthus minor
(ARAPPT, CUE1, NOX1, PPT, AT5G33320) mutants downregulated (ATFRO2, FRD1, FRO2, AT1G01580) transcripts Arabidopsis thaliana
(HTB4, AT5G59910) may play a role in modulating iron uptake/homeostasis in alkaline soil environments Arabidopsis thaliana
up-regulation of (S8H, AT3G12900) (ATFRO2, FRD1, FRO2, AT1G01580) (ATIRT1, IRT1, AT4G19690) etc is a common phenomenon observed in plants grown under iron deficiency Populus trichocarpa
nitric oxide (NO) is involved in regulation of plant iron homeostasis Arabidopsis thaliana
disruption or inhibition of heterodimer complex formation between (PYE, AT3G47640) and PYEL proteins could potentially perturb downstream iron deficiency-responsive genes regulated by (PYE, AT3G47640) Arabidopsis thaliana
H3K4me3 enrichment at clade Ib (bHLH, AT5G51780) promoters promotes expression of clade Ib bHLHs Arabidopsis thaliana
(ZIF1, AT5G13740) increases the concentration of nicotianamine in the vacuole Arabidopsis thaliana
(MTP8, AT3G58060) is not upregulated in germinating (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant Arabidopsis thaliana
assimilation of Fe is under complex, multifaceted control Arabidopsis thaliana
Ib subgroup basic helix–loop–helix (bHLH) transcription factors are involved in iron (Fe) homeostasis
(BTS, EMB2454, AT3G18290) physically interacts with (bHLH115, AT1G51070) Arabidopsis thaliana
(ATFRD3, FRD3, MAN1, AT3G08040) in pollen grain and embryos suggests complex mechanism of iron nutrition during embryogenesis Arabidopsis thaliana
Fe resupply to 10 µm Fe-EDTA leads to rise in Fe levels in rosette Arabidopsis thaliana
(ATFER1, FER1, AT5G01600) expression was decreased after 2 days of Fe deficiency Arabidopsis thaliana
iron limitation impacts cytosolic aconitase at posttranslational level Arabidopsis thaliana
citrate chelates Fe
YSL (Yellow Stripe-Like) proteins transport Fe across membranes
ferritin-mediated checkpoints for iron transport is critical for healthy embryo development Arabidopsis thaliana
increased AHA protein levels facilitates enhanced rhizosphere acidification Arabidopsis thaliana
decreased (BTS, EMB2454, AT3G18290) activity leads to elevated rhizosphere acidification, iron reductase activity, and iron uptake Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) protein under low-iron conditions is more stable and regulates PYEL/ (PYE, AT3G47640) regulatory activity through E3 ligase activity Arabidopsis thaliana
enhanced rhizosphere acidification could be attributed to slight increases in shoot and root iron content Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) contains both iron-sensing and E3 ligase activities Arabidopsis thaliana
(bHLH105, ILR3, AT5G54680) controls expression of iron transporters Arabidopsis thaliana
Fe availability affects Fe content in plant rosettes Arabidopsis thaliana
ferritin function in the physiology of plants is more related to the protection against free iron toxicity than to the establishment of a reserve pool
seed metals from wild-type Arabidopsis and ferritin mutant plants was measured in wild-type Arabidopsis and ferritin mutant plants Arabidopsis thaliana
alterations in Fe transport across the vacuolar membrane potentially lead to major alterations in Fe localization and bioavailability Arabidopsis thaliana
iron (Fe) homeostasis includes iron uptake from soil via roots
identification of additional mechanisms controlling xylem loading of iron (Fe) remains an important goal for full understanding of plant iron (Fe) homeostasis
(ABCB23, ATATM1, ATM1, AT4G28630) may have distinct function Arabidopsis thaliana
(ABCB24, ATATM2, ATM2, AT4G28620) has not yet been fully characterized in function function Arabidopsis thaliana
Nicotianamine synthase 1 and 4 are up-regulated by iron deficiency Arabidopsis thaliana
FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) is posttranslationally regulated by nitric oxide Arabidopsis thaliana
MtMATE67 has key role in Fe uptake into nodule cells Medicago truncatula
NRAMP overexpressors affects iron homeostasis of vacuolar and plastidial compartments Arabidopsis thaliana
ferritin accumulation in 35S::Nramp3 overexpressor lines was similar in various (ATNRAMP3, NRAMP3, AT2G23150) and (ATNRAMP4, NRAMP4, AT5G67330) overexpressor lines compared to Col Arabidopsis thaliana
loss of (BTS, EMB2454, AT3G18290) induction leads to increased tolerance to iron deficiency Arabidopsis thaliana
Oryza sativa Hemerythrin motif-containing RING and Zinc-Finger Protein1 (OsHRZ1) is (BTS, EMB2454, AT3G18290) ortholog in rice Oryza sativa
SUFB, FDX2, and (SAPX, AT4G08390) transcripts remained low over 1-week Fe depletion Arabidopsis thaliana
MtNramp1 mutant compromises symbiotic nitrogen fixation (SNF) Medicago truncatula
citrate transport by MATE proteins helps to mobilize Fe
increased growth in (S8H, AT3G12900) mutants and Ox lines was accompanied by higher shoot Fe content Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) does not interact with (PYE, AT3G47640) Arabidopsis thaliana
rhizosphere acidification coupled with higher (ATFRO2, FRD1, FRO2, AT1G01580) and (ATIRT1, IRT1, AT4G19690) activity leads to increased solubility and transport of iron into root epidermal cells Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) interacts with iron-responsive (bHLH, AT5G51780) transcription factors (bHLH105, ILR3, AT5G54680) and (bHLH115, AT1G51070) Arabidopsis thaliana
good correlation between protein and mRNA abundance was observed Fe deficiency response Arabidopsis thaliana
higher shoot Fe content in (S8H, AT3G12900) mutants and Ox lines might be due to reduced demand for Fe required as a cofactor for (F6'H1, AT3G13610) and (S8H, AT3G12900) in the mutants and improved Fe uptake due to increased production of Fe-mobilizing compounds in the Ox lines Arabidopsis thaliana
mutation in (ATVIT1, VIT1, AT2G01770) leads to mislocalization of Fe in seed Arabidopsis thaliana
increase in iron accumulation in tissues is correlated with increase in ferritin abundance Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) is critical iron-sensing E3 ubiquitin ligase Arabidopsis thaliana
(At-NEET, NEET, AT5G51720) ([2Fe-2S] protein) is transcriptionally downregulated in (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) at days 1 and 3 Arabidopsis thaliana
ferritin in flowers protect against iron overload
mir plants may not be able to utilize iron for physiological functions Oryza sativa
(AtTic21, CIA5, PIC1, TIC21, AT2G15290) mutants could not be rescued by excess Fe Arabidopsis thaliana
Oryza sativa Hemerythrin motif-containing RING and Zinc-Finger Protein2 (OsHRZ2) is (BTS, EMB2454, AT3G18290) ortholog in rice Oryza sativa
(BTS, EMB2454, AT3G18290) negatively regulates iron deprivation responses Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) could mediate iron homeostasis through interaction with other PYEL proteins Arabidopsis thaliana
(FER, AT3G51550) knockout mutants affects iron homeostasis of vacuolar and plastidial compartments Arabidopsis thaliana
Fe in mir plants is present in form that cannot be easily used by plants
(BTS, EMB2454, AT3G18290) is hypothesized to negatively regulate iron homeostasis Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) could mediate response to iron deprivation Arabidopsis thaliana
accumulation of PYEL protein (bHLH105, ILR3, AT5G54680) controls iron availability for auxin homeostasis Arabidopsis thaliana
Fe(III) solubility and mobility in the apoplasm enables uptake of Fe into nodule cells Medicago truncatula
IAA-LEUCINE RESISTANT3 (bHLH105, ILR3, AT5G54680) may transcriptionally control expression of iron transporters Arabidopsis thaliana
plastids should play central role in maintaining Fe homeostasis in green tissues
loss of MtMATE67 gene function resulted in accumulation of Fe in the apoplasm of nodule cells Medicago truncatula
POPEYE (PYE, AT3G47640) interacts with IAA-LEUCINE RESISTANT3 (bHLH105, ILR3, AT5G54680) (bHLH104, AT4G14410) and (bHLH115, AT1G51070) Arabidopsis thaliana
higher accumulation of BBΔHG protein in roots could attenuate iron deficiency response Arabidopsis thaliana
(ATFER1, FER1, AT5G01600) expression is decreased in 1-day-old and 3-day-old (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) plants Arabidopsis thaliana
delay in establishment of photosynthesis represents a highly efficient way to spare iron Arabidopsis thaliana
(TTL3, VIT, AT2G42580) (Vacuolar Iron Transporter) proteins transport Fe across membranes
nramp3-4 genetic background results in lower accumulation of (ATFER2, FER2, AT3G11050) protein Arabidopsis thaliana
ectopic overexpression of (ATNRAMP4, NRAMP4, AT5G67330) was tested to alter Fe vacuolar transport efflux Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) is induced in response to iron deficiency Arabidopsis thaliana
Fe-deficient plants quickly recover after Fe resupply Arabidopsis thaliana
SUFB is downregulated in (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant at early stages Arabidopsis thaliana
iron-binding HHE domains do not participate directly in root growth phenotype, rhizosphere acidification, and iron reductase activity under iron deficiency Arabidopsis thaliana
iron deficiency response allows the mutant to overcome defect in vacuolar export Arabidopsis thaliana
core-promoter element insertion can enhance iron-regulated transporter1 gene expression
PYE-like (PYEL) proteins interact with BRUTUS (BTS, EMB2454, AT3G18290) Arabidopsis thaliana
bts-1 mutant exhibits lower (ATIRT1, IRT1, AT4G19690) protein level Arabidopsis thaliana
loss of (BTS, EMB2454, AT3G18290) function may be due to perturbations in regulation of iron translocation into developing siliques and embryos Arabidopsis thaliana
(ATNRAMP4, NRAMP4, AT5G67330) overexpressor does not show decrease in ferritin abundance
mitochondrial iron-regulated (MIR) protein plays a significant role in iron homeostasis Oryza sativa
YSL ( (ATYSL1, YSL1, AT4G24120) and (ATYSL3, YSL3, AT5G53550) ) is critical for iron translocation to developing embryo and into seed coat Arabidopsis thaliana
complex, multifaceted control of Fe assimilation is required to keep Fe within a tight cellular concentration Arabidopsis thaliana
MIR is not expressed in mir plants grown under Fe-sufficient conditions
up-regulation of Fe-deficiency responsive genes appears to be responsible for high accumulation of Fe in mir plants
Chlamydomonas PGRL1 is up-regulated under iron deprivation Chlamydomonas reinhardtii
OSOPT4 has undetermined role in iron homeostasis Oryza sativa
Fe limitation causes significant decrease in shoot Fe content Arabidopsis thaliana
215 down-regulated genes are associated with iron ion transport Arabidopsis thaliana
accumulation of (BTS, EMB2454, AT3G18290) is affected by binding iron through HHE domains Arabidopsis thaliana
truncated BBΔHG shows in vivo accumulation compared with BBG irrespective of iron status in roots Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) accumulates under iron deprivation Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) targets regulatory components of iron deficiency pathway Arabidopsis thaliana
alterations in Fe transport across the vacuolar membrane influence ferritin synthesis during fruit development Arabidopsis thaliana
(ATVIT1, VIT1, AT2G01770) mediates vacuolar influx of iron Arabidopsis thaliana
sparing solubility of Fe limits availability of Fe to plants
(ABCB23, ATATM1, ATM1, AT4G28630) plays an important role in overall cellular Fe homeostasis non-plant eukaryotes
loss of Fe export mechanisms could explain Fe homeostasis phenotypes Arabidopsis thaliana
loading and unloading of iron into and from the vacuole are important determinants of the control of iron homeostasis in seeds Arabidopsis thaliana
(ATFER2, FER2, AT3G11050) ferritin abundance in seeds of nramp3-4 mutant showed a decrease in nramp3-4 mutant Arabidopsis thaliana
chloronerva (chln) mutant indicates inadequate iron Solanum lycopersicum
low-iron conditions up-regulate (ATFRO2, FRD1, FRO2, AT1G01580) and (ATIRT1, IRT1, AT4G19690) Arabidopsis thaliana
inhibition of mitochondrial Fe transport leads to Fe accumulation in vacuoles Saccharomyces cerevisiae
ferritin plays important role in Fe homeostasis
OsYSL2 expression suggests a role in Fe-uptake process Oryza sativa
OsOPT1 has undetermined role in iron homeostasis Oryza sativa
heme biosynthesis occurs in plastids
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) expression in Δmrs3 Δmrs4 would be expected if (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) were a mitochondrial iron importer Saccharomyces cerevisiae
increased level of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) transcripts in iron-deficient roots is primarily driven by local iron conditions Arabidopsis thaliana
transcripts of (ATFER1, FER1, AT5G01600) (ATFER3, FER3, AT3G56090) and (ATFER4, FER4, AT2G40300) accumulate under iron sufficiency Arabidopsis thaliana
iron undergoes solubilization
iron undergoes remobilization
(TTL3, VIT, AT2G42580) overexpressors affects iron homeostasis of vacuolar and plastidial compartments Arabidopsis thaliana
samples from Col, (ATFER2, FER2, AT3G11050) fer1-3-4, and fer1-2-3-4 mutant plants were grown on soil without Fe supplementation Arabidopsis thaliana
citrate may affect iron (Fe) distribution at a local level within leaves Arabidopsis thaliana
AtFPN2 (ATIREG2, FPN2, IREG2, AT5G03570) mediates sequestration of toxic metals during Fe deficiency Arabidopsis thaliana
iron deficiency induces twofold increase in AtOPT3 expression in leaves Arabidopsis thaliana
chloronerva (chln) mutant constitutively activate root iron-uptake systems Solanum lycopersicum
loss of Arabidopsis (ABCB25, ATATM3, ATM3, STA1, AT5G58270) resulted in severe growth defects and chlorosis Arabidopsis thaliana
(ATOPT3, OPT3, AT4G16370) is in same regulatory network as other iron-partitioning genes Arabidopsis thaliana
(ATYSL1, YSL1, AT4G24120) (ATYSL2, YSL2, AT5G24380) and (ATYSL3, YSL3, AT5G53550) participate in distinct aspect of iron homeostasis Arabidopsis thaliana
Iron (Fe) is sequestered into vacuoles Oryza sativa
allelic insertion of (TATA, AT5G28750) box in iron-regulated transporter 1 promoter increases promoter activity Malus
overexpression of MRS3 and MRS4 suppressed iron toxicity Saccharomyces cerevisiae
(ATOPT3, OPT3, AT4G16370) expression upregulation only in GA shoots suggests that (ATOPT3, OPT3, AT4G16370) regulates shoot-to-root iron signaling Noccaea caerulescens
Vacuolar Iron Transporter 1 (OsVIT1) sequesters Iron (Fe) into vacuoles Oryza sativa
Fe homeostasis perturbation leads to growth impairments
(ATVIT1, VIT1, AT2G01770) is required for cell-specific Fe localization in Arabidopsis embryos Arabidopsis thaliana
PYE1 and (ATOPT3, OPT3, AT4G16370) are co-regulated Arabidopsis thaliana
transcription factor (ATBHLH029, ATBHLH29, ATFIT1, BHLH029, FIT, FIT1, FRU, AT2G28160) in concert with members of subgroup I of bHLH proteins triggers expression of (ATFRO2, FRD1, FRO2, AT1G01580) Arabidopsis thaliana
Fe deficiency induces expression of POPEYE (PYE, AT3G47640) Arabidopsis thaliana
IRON MAN (IMA) peptide class is preferentially expressed in leaves Arabidopsis
ethylene is involved in the up-regulation of NICOTIANAMINE SYNTHASE 2 (ATNAS2, NAS2, AT5G56080) Arabidopsis thaliana
OsNAS1 is nicotianamine synthase Oryza sativa
mir plants accumulated more than twice the amount of iron in shoot tissue Oryza sativa
(ATYSL1, YSL1, AT4G24120) (ATYSL2, YSL2, AT5G24380) and (ATYSL3, YSL3, AT5G53550) are not involved in iron acquisition Arabidopsis thaliana
Fe content in (AtTic21, CIA5, PIC1, TIC21, AT2G15290) mutants was unchanged (AtTic21, CIA5, PIC1, TIC21, AT2G15290) mutants Arabidopsis thaliana
mir plants grown under Fe-deficient conditions still showed symptoms of Fe deficiency
AtFPN1 mediates loading of Fe into xylem Arabidopsis thaliana
OsYSL2 mediates translocation of Fe from root to shoot Oryza sativa
ysl1ysl3 double mutant leaves grown on standard tissue culture medium show decreased iron levels Arabidopsis thaliana
atm3-1 mitochondria did not contain elevated levels of iron (Fe) Arabidopsis thaliana
a plastid Fe sensor (ABCI11, ATNAP14, NAP14, AT5G14100) monitors Fe status Arabidopsis thaliana
MIR plays significant role in rice Fe homeostasis via mitochondrion Oryza sativa
atm3-1 mutants had low levels of IRT1 protein at 10 and 20 μM Fe Arabidopsis thaliana
levels of Fe in the chloroplast must be tightly regulated chloroplast function and homeostasis
mitochondria and chloroplasts are organelles with high iron demand Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) may be involved in iron homeostasis Arabidopsis thaliana
HsFPN Asp325 is conserved among vertebrate FPNs Vertebrata
shoot-to-root iron signaling could be regulated by (ATOPT3, OPT3, AT4G16370) Noccaea caerulescens
transporter proteins feature prominently as mediators of Fe homeostatic control
mitochondria have iron as the major micronutrient present with a molar ratio of 26:8:6:1 for Fe:Zn:Cu:Mn
mitochondrial frataxin is involved in Fe–S cluster and heme biogenesis
(MIT1, AT2G30160) and (MIT2, AT1G07030) are essential for embryogenesis Arabidopsis thaliana
transcript levels of organellar iron-responsive genes would be affected in (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) mutant lines Arabidopsis thaliana
disruption of iron fluxes between seed vacuoles and plastids reveals post-transcriptional control of (ATFER2, FER2, AT3G11050) seed-specific ferritin gene Arabidopsis thaliana
ferritin accumulation in 35S::NRamp4 overexpressor lines was similar in various (ATNRAMP3, NRAMP3, AT2G23150) and (ATNRAMP4, NRAMP4, AT5G67330) overexpressor lines compared to Col Arabidopsis thaliana
low basal levels of transcripts of key iron transporters such as OsIRT2 suggests that salt-tolerant lines may be inherently more able to tolerate Fe-deficiency conditions
(ATIRT1, IRT1, AT4G19690) is primary iron uptake transporter from soil Arabidopsis thaliana
iron-deficiency response in roots is regulated by local signal determined by iron level in rhizosphere Arabidopsis thaliana; multiple plant species
(AtYSL4, YSL4, AT5G41000) and (AtYSL6, YSL6, AT3G27020) encode transporters that efflux iron–NA from chloroplasts or vacuoles Arabidopsis thaliana
iron subcellular localization is tightly regulated to ensure optimal utilization and bioavailability
215 down-regulated genes are associated with cellular response to iron starvation Arabidopsis thaliana
BRUTUS (BTS, EMB2454, AT3G18290) is induced in response to low iron Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) interacts with (bHLH115, AT1G51070) Nicotiana benthamiana
higher (ATFRO2, FRD1, FRO2, AT1G01580) activity facilitates enhanced rhizosphere acidification Arabidopsis thaliana
SCF FBXL5 E3 ligase complex regulates iron homeostasis Homo sapiens
Fe deficiency causes decrease in abundance of several Fe binding proteins Arabidopsis thaliana
Iron (Fe) is essential for multiple pathways in plants
aconitase activity could not be restored by providing high concentration of external iron Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) is expressed in Δmmt1/2 yeast mutant Saccharomyces cerevisiae
higher level of (ATFRO8, FRO8, AT5G50160) in iron-deficient (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) shoots may imply dysregulation of iron-dependent mitochondrial function Arabidopsis thaliana
iron undergoes chelation
(ATNRAMP3, NRAMP3, AT2G23150) and (ATNRAMP4, NRAMP4, AT5G67330) mediate vacuolar efflux of iron Arabidopsis thaliana
(ATYSL1, YSL1, AT4G24120) (ATYSL2, YSL2, AT5G24380) and (ATYSL3, YSL3, AT5G53550) expression is down-regulated by iron limitation Arabidopsis thaliana
ferritin protein had a corresponding increase in protein level in (AtTic21, CIA5, PIC1, TIC21, AT2G15290) mutants Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) contains conserved iron transport residues Arabidopsis thaliana; Homo sapiens; Mus musculus; Danio rerio; Xenopus laevis; bacteria
iron content in (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) shoots was reduced in (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) shoots Arabidopsis thaliana
Ib subgroup (bHLH, AT5G51780) genes are required for regulation of iron uptake and homeostasis Arabidopsis thaliana
(ATFER3, FER3, AT3G56090) mRNA abundance increases in response to iron treatment Arabidopsis thaliana
MIR transcripts are less abundant in Fe-sufficient WT roots and shoots
(ATYSL1, YSL1, AT4G24120) (ATYSL2, YSL2, AT5G24380) and (ATYSL3, YSL3, AT5G53550) mediate influx of Fe(II)–NA complexes Arabidopsis thaliana
chloroplasts are the most iron-rich organelle in plant cells and account for 60–80% of the iron found in a leaf cell
expression of MMT1/2 resulted in reduced growth under high iron conditions Saccharomyces cerevisiae
abnormal mitochondrial morphology in iron-deficient (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) leaves suggests critical role for (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) in the mitochondria under iron deficiency Arabidopsis thaliana
(MIT1, AT2G30160) and (MIT2, AT1G07030) mediate cellular iron homeostasis Arabidopsis thaliana
iron-dependent mitochondrial ultrastructure phenotype strongly suggests that (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) function is critical for mitochondria under iron-deficient conditions Arabidopsis thaliana
nicotianamine biosynthesis pathway was overrepresented pathway upregulated by cadmium Noccaea caerulescens
milder iron deficiency response in LC roots could be due to absence of iron deficiency signal from shoot Noccaea caerulescens
(AtPMRT5, CAU1, PRMT5, SKB1, AT4G31120) mutant results in higher iron accumulation in shoots Arabidopsis thaliana
cells have evolved co-ordinated mechanisms to maintain labile Fe pool (LIP) within physiological values
nicotianamine (NA) has role in establishment of extracellular iron pool
ferritin is present in mitochondria and plastids
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) is not likely to import iron into the mitochondria Saccharomyces cerevisiae
overall distribution of iron did not differ among genotypes Arabidopsis thaliana
mitochondrial ultrastructure phenotypes were not detected under iron-sufficient conditions Arabidopsis thaliana
iron undergoes oxidation/reduction
success of iron biofortification relies on knowledge of the cross-talks integrating unloading transport mechanisms to intracellular storage processes
down-regulation of Fe transporters in response to salinity indicates that IR29 may be vulnerable to Fe deficiency under saline conditions
ZmYS1, HvYS1, and OsYSL15 mediate influx of Fe(III)–PS complexes Zea mays; Hordeum vulgare; Oryza sativa
chlorosis in ysl1ysl3 double mutant can be reversed by application of Fe-EDDHA solution to soil Arabidopsis thaliana
disruption of (ABCB23, ATATM1, ATM1, AT4G28630) causes phenotype of cytosolic Fe deficiency non-plant eukaryotes
subcellular localization of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) in mitochondria and chloroplasts and yeast results suggest (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) is exporting iron from these organelles Arabidopsis thaliana; Saccharomyces cerevisiae
mitochondria of iron-deficient (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) mutants were enlarged Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) mutants cannot grow as well as wild type under iron-deficient conditions Arabidopsis thaliana
ferrous iron is major substrate of FPN orthologs
transcripts of (ATFER1, FER1, AT5G01600) (ATFER3, FER3, AT3G56090) and (ATFER4, FER4, AT2G40300) decrease when iron levels are low Arabidopsis thaliana
ultrastructure of mitochondria has also been shown to be affected by iron deficiency in plants plants
chloroplasts of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) and wild type showed no discernable differences Arabidopsis thaliana
intricate balance of mitochondrial iron trafficking is necessary for optimal iron regulation at the tissue level Arabidopsis thaliana
Fe overload stress is associated with increase in labile iron pool (LIP)
tomato chl mutant shows apparent iron deficiency phenotype in NA-free condition Solanum lycopersicum
leaves of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) mutants accumulated less iron compared with wild type Arabidopsis thaliana
(ATFRO7, FRO7, AT5G49740) transcript levels were similar across all three genotypes Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) on mitochondrial and chloroplast metabolism and oxidative stress requires further studies to elucidate mechanisms underlying the phenotypes observed Arabidopsis thaliana
roots of both accessions showed upregulation of iron(III) reduction and iron(II) transport Noccaea caerulescens
growth of Δccc1 Δmmt1/2 expressing (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) was decreased under high iron conditions and approximated that of Δccc1 Δmmt1/2 expressing MMT1/2 Saccharomyces cerevisiae
iron export by (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) is necessary for optimal iron regulation at the tissue level Arabidopsis thaliana
iron participates in transport activities
cellular responses to iron deficiency is examined for advances in understanding iron homeostasis
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) exports iron from mitochondria Saccharomyces cerevisiae
iron content of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) mutant shoot is significantly lower than that of wild type under both iron-sufficient and iron-deficient conditions Arabidopsis thaliana
iron often limits plant growth
(ATFER4, FER4, AT2G40300) mRNA abundance increases in response to iron treatment Arabidopsis thaliana
(ABCB25, ATATM3, ATM3, STA1, AT5G58270) suppresses high-affinity Fe uptake associated with loss of chromosomal ScATM1 Saccharomyces cerevisiae
iron (Fe) deficiency triggers transcription factor (ATBHLH029, ATBHLH29, ATFIT1, BHLH029, FIT, FIT1, FRU, AT2G28160) and (bHLH, AT5G51780) proteins triggering expression of (ATFRO2, FRD1, FRO2, AT1G01580) and (ATIRT1, IRT1, AT4G19690) Arabidopsis thaliana
General Control Non-repressed 5 (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) mutation of results in impaired iron translocation from root to shoot Arabidopsis thaliana
accumulation of iron in (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) mutant chloroplasts and mitochondria provides strong evidence that supports role of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) in exporting iron from mitochondria and chloroplast Arabidopsis thaliana
transcript levels of (ATFER1, FER1, AT5G01600) and (ATFER3, FER3, AT3G56090) were significantly lower in iron-sufficient shoots of fpn3 compared with wild type Arabidopsis thaliana
roots of both accessions showed upregulation of nicotianamine biosynthesis Noccaea caerulescens
HvID17 expression is strongly induced by iron deficiency Hordeum vulgare
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) is expressed in Δmrs3 Δmrs4 yeast mutant Saccharomyces cerevisiae
abnormal chloroplast ultrastructure has been observed in mutants grown under iron deficiency multiple plant species
young nramp3nramp4 double mutant seedlings exhibited transient pale cotyledon phenotype Arabidopsis thaliana
allelic insertion of (TATA, AT5G28750) box in iron-regulated transporter 1 promoter allows adaptation to iron deficiency Malus
iron released from haem degradation induces iron-sequestering proteins such as ferritin
K1 line shows iron-starved molecular phenotype in iron-sufficient conditions Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) expression increased under iron deficiency Arabidopsis thaliana
inter- and intracellular distribution of Fe had to be established by organisms such as plants
Ala at the corresponding position in AtFPN1 and AtFPN2 is found in lieu of Glu or Asp Arabidopsis thaliana
split roots pre-grown under iron deficiency exhibited higher levels of FPN3 only when subjected to additional duration of iron deficiency Arabidopsis thaliana
ethylene is involved in the up-regulation of MYB DOMAIN PROTEIN 72 (ATMYB72, MYB72, AT1G56160) Arabidopsis thaliana
ethylene is involved in the up-regulation of FERRIC REDUCTASE DEFECTIVE 3 (ATFRD3, FRD3, MAN1, AT3G08040) Arabidopsis thaliana
Fe concentration in roots and shoots shows no difference among wild-type rice (WT), vector control (VC), and OsHMA3 overexpressed line (OX) Oryza sativa
Asn174 and Arg466 of HsFPN are highly preserved in (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) and other FPNs Homo sapiens; Arabidopsis thaliana; bacteria
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) single mutants grown in alkaline soil phenotype was recovered when watered with soluble iron Arabidopsis thaliana
function of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) is necessary in roots under iron deficiency Arabidopsis thaliana
plants supplied with both S and Fe maintain very low levels of PS release Hordeum vulgare
accumulation of FSD in white sectors is explained by lack of Reiske Fe-S protein in cytochrome b6/f Arabidopsis thaliana
Fe deficiency up-regulates Fe-related genes Arabidopsis thaliana
(ATFRD3, FRD3, MAN1, AT3G08040) (ferric reductase defective 3, ) is involved in root iron metabolism Arabidopsis thaliana
Fe requirement for proper microspore development or pollen germination could be met in N22 and IR64 through chelating and transportation mechanism across the plasma membrane Oryza sativa
ethylene is involved in the up-regulation of BASIC HELIX-LOOP-HELIX 38 (AtbHLH38) Arabidopsis thaliana
(ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) plays a critical role in iron homeostasis Arabidopsis thaliana
chloroplasts may be better equipped with mechanisms that compensate for defective (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) function under iron-deficient conditions Arabidopsis thaliana
iron homeostasis is mediated by regulatory networks
iron (Fe) limitation invokes ethylene production
labile Fe pool (LIP) can be scavenged by permeant chelators
small organic molecules including organic acids, amino acids and their derivatives play key roles in iron homeostasis in plants
deregulation of iron acquisition systems in K1 line results in high sensitivity to iron starvation Arabidopsis thaliana
biological targets include effect on Fe homeostasis
higher Fe-deficiency protein expression is similar to barley roots under Fe deficiency Hordeum vulgare
exogenously applied NO induces greening in Fe-deficient maize plants Zea mays
iron deficiency occurs frequently plants
iron transport across subcellular compartments is crucial for proper iron homeostasis
elevated (ATFRO3, FRO3, AT1G23020) expression levels in (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) shoots are consistent with less cytosolic iron Arabidopsis thaliana
mitochondrial phenotype of (ATIREG3, FPN3, IREG3, MAR1, RTS3, AT5G26820) signifies importance of iron export from the mitochondria under iron-deficient conditions Arabidopsis thaliana
OsIRO2 is iron-regulated (bHLH, AT5G51780) transcription factor Oryza sativa
ethylene no ethylene production or ethylene-mediated effects of iron response could be detected in Hordeum vulgare L. (barley) Hordeum vulgare L.
lpa1-241 mutant contained about 50% more free or weakly bound iron Zea mays
mechanisms to control iron uptake, transport, and storage prevent iron deficiency
K1 line shows similar iron levels in roots and shoots compared to wild-type plants Arabidopsis thaliana
exogenous DNA methyltransferase inhibitor (5-azacytidine) treatment results in decreased Fe content in rice plants Oryza sativa
plant cells must regulate iron to ensure adequate supply while avoiding oxidative stress
iron transport in mitochondria and chloroplasts is not as well understood as mechanisms of iron acquisition in the roots
(ATFRO3, FRO3, AT1G23020) and (ATFRO8, FRO8, AT5G50160) are likely to play non-overlapping roles Arabidopsis thaliana
increased iron levels in roots is in apparent contradiction with finding that GA roots exhibited iron deficiency response Noccaea caerulescens
(ATFRD3, FRD3, MAN1, AT3G08040) is involved with Fe nutrition Arabidopsis thaliana
Fe re-supply restores Fe concentration in leaves Oryza sativa
exogenous nitric oxide (NO) interacts with iron (Fe) Sorghum bicolor
ferritin is main Fe storage protein
oldest leaf had similar SPAD values in +Fe- and –Fe-treated plants SPAD values Zea mays
K1 line shows decrease of water-extractable iron fraction Arabidopsis thaliana
functional analysis of HvYS1 homologues will help understand iron transport system in whole plants Hordeum vulgare
ZmYS1 expression is regulated by Fe status in leaf blades Zea mays
OsIRT1 is iron-regulated transporter Oryza sativa
iron (Fe)-limiting conditions increased ethylene production Oryza sativa
NA-overaccumulating line has similar iron levels in roots under iron-deficient conditions Arabidopsis thaliana
ACC treatment significantly increases soluble Fe concentration Oryza sativa
ethylene inhibitors has no significant effect on total Fe concentration Oryza sativa
exogenous GB application enhanced expression of genes for NADP-dependent ferric reductase located on plasma membrane Arabidopsis thaliana
rice roots grown under iron-depleted conditions show significantly increased ethylene production Oryza sativa
OsIRO2 RNA interference in transgenic rice showed that ethylene acted via OsIRO2 to induce expression of OsNAS1, OsNAS2, OsYSL15, and OsIRT1 Oryza sativa
AVG treatment further increases Fe content in WT by ~22% in shoot Arabidopsis thaliana
1-aminocyclopropane-1-carboxylic acid (ACC) treatment increases internal iron (Fe) availability Oryza sativa
iron (Fe)-limiting conditions increased ethylene signalling Oryza sativa
modulation of cellular iron (Fe) status is important factor for regulation of plant physiology Sorghum bicolor
nitric oxide (NO) reacts with Fe
(ATFER1, FER1, AT5G01600) expression is stimulated in both WT and eto1-1 in response to excess Fe Arabidopsis thaliana
unicellular algae utilize unique mechanisms of iron uptake
surface-binding properties of E. siliculosus function as a sort of metal ion 'buffer' allowing iron uptake under widely varying external iron concentrations Ectocarpus siliculosus
labile Fe pool (LIP) is defined operationally as cell chelatable pool comprising both ionic forms of Fe (Fe2+ and Fe3+) associated with diverse population of ligands
extracellular NA in the apoplast could be major checkpoint to control plant iron homeostasis Arabidopsis thaliana
Fe-related genes up-regulated by ethylene are responsive to nitric oxide (NO) Arabidopsis thaliana
nitric oxide (NO) is involved in the up-regulation of FERRIC REDUCTASE DEFECTIVE 3 (ATFRD3, FRD3, MAN1, AT3G08040) Arabidopsis thaliana
ethylene-mediated iron response is novel in Strategy II plant species Oryza sativa
K1 line phenotype mimics apparent iron deficiency phenotype Arabidopsis thaliana
NO has effects on Fe homeostasis upon early stages of germination Sorghum bicolor
low level of (ATIRT1, IRT1, AT4G19690) and (ATFRO2, FRD1, FRO2, AT1G01580) activities prevents excess iron uptake Arabidopsis thaliana
ethylene inhibitors has no significant effect on soluble Fe concentration Oryza sativa
Mn deficiency causes down-regulation of genes involved in Fe acquisition Arabidopsis thaliana
NA-overaccumulating Arabidopsis line enabled insights into potential role of nicotianamine (NA) in iron homeostasis Arabidopsis thaliana
(HTB4, AT5G59910) controls (ATFRO2, FRD1, FRO2, AT1G01580) and (ATIRT1, IRT1, AT4G19690) expression Arabidopsis thaliana
regulation of iron homeostasis is primarily controlled at transcriptional level
downregulated genes in (HTB4, AT5G59910) mutant are involved in cellular response to iron ion starvation Arabidopsis thaliana
loss of function of (HTB4, AT5G59910) disrupts Fe homeostasis Arabidopsis thaliana
(HTB4, AT5G59910) might enhance gene expression of (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) Arabidopsis thaliana
(PYE, AT3G47640) and clade IVc (bHLH, AT5G51780) interaction negatively regulates (PYE, AT3G47640) expression Arabidopsis thaliana
IMA-encoded peptides inhibit activity of hemerythrin E3 ubiquitin ligases ( (BTS, EMB2454, AT3G18290) (BTSL1, AT1G74770) and (BTSL2, AT1G18910) ) Arabidopsis thaliana
iron uptake and storage mechanisms have been well studied in terrestrial/higher plants
(ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) homology model predicts acidic triad (E269, D370, and D462) for Fe2+-binding Arabidopsis thaliana
iron uptake and iron storage balance is allowed by interactions between regulatory proteins Arabidopsis thaliana
(HTB4, AT5G59910) mutant plants under Fe deficiency conditions shows decreased induction of (ATFRO2, FRD1, FRO2, AT1G01580) expression Arabidopsis thaliana
epigenetic regulation is one of the most important mechanisms to regulate iron homeostasis
iron uptake and storage mechanisms have received far less attention in marine algae
(UBC13, AT3G46460) is responsive to iron (Fe) regime Cucumis sativus; Arabidopsis thaliana
iron in excess is detrimental to the plant
(HTB4, AT5G59910) expression is induced under iron deficiency Arabidopsis thaliana
(BHLH100, AT2G41240) is suppressed in (HTB4, AT5G59910) mutant
Fe starvation induces (HTB4, AT5G59910) expression Arabidopsis thaliana
Col-0 plants under Fe-deficient conditions shows induced (ATFRO2, FRD1, FRO2, AT1G01580) expression Arabidopsis thaliana
accumulation of excess free Fe 2+ must be prevented plant survival
(ATFER2, FER2, AT3G11050) expression is stimulated in both WT and eto1-1 in response to excess Fe Arabidopsis thaliana
SNP (NO donor) partially reversed Fe deficiency-induced retardation of plant growth
small organic molecules including organic acids, amino acids and their derivatives form chelates involved in long distance trafficking of iron
phytosiderophore secretion into rhizosphere allows iron chelation and uptake
carbon monoxide (CO) plays an important signal in iron homeostasis
WT shoots under excess Fe contain ~68% more Fe than eto1-1 mutant shoots Arabidopsis thaliana
receptor kinase (SRF3, AT4G03390) coordinates iron homeostasis Arabidopsis thaliana
(MIA, PDR2, AT5G23630) /AtP5A restricts LOW PHOSPHATE ROOT 1 (ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) function Arabidopsis thaliana
(ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) exhibits optimal activity at pH 5.8 Arabidopsis thaliana
quasibiological metal ion buffer function of Ectocarpus siliculosus allows iron uptake under widely varying external iron concentrations Ectocarpus siliculosus
ferritin genes induction is significantly higher in eto1-1 than in WT under excess Fe Arabidopsis thaliana
(BHLH100, AT2G41240) is Fe-deficiency responsive gene Arabidopsis thaliana
plants apply diverse mechanisms to regulate expression and activity of iron homeostasis components
ethylene acted via OsIRO2 Oryza sativa
IDEF1 overexpression did not change total Fe content in rice Oryza sativa
SNP (NO donor) partially reversed Fe deficiency-induced chlorosis
(AtPHR1, PHR1, AT4G28610) regulates expression of the iron-storage protein FERRITIN 1 Arabidopsis thaliana
coccolithophores, diatoms, and unicellular green algae utilize unique mechanisms of iron uptake
(ATHO1, GUN2, HO1, HY1, HY6, TED4, AT2G26670) was induced by iron deficiency Arabidopsis thaliana
PYE-like (PYEL) proteins are up-regulated during iron deficiency Arabidopsis thaliana
bts-1 /BBG line 1-2 exhibits recovery of (ATIRT1, IRT1, AT4G19690) protein levels similar to wild-type Arabidopsis thaliana
BRUTUS and BRUTUS LIKE1 are upregulated in (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant Arabidopsis thaliana
MATE (Multidrug And Toxic-compound Extrusion) proteins transport citrate
SCF FBXL5 E3 ligase complex interacts with iron homeostasis proteins Homo sapiens
(BTS, EMB2454, AT3G18290) interacts with (bHLH105, ILR3, AT5G54680) Nicotiana benthamiana
(BTS, EMB2454, AT3G18290) is structurally and functionally similar to FBXL5 Arabidopsis thaliana; Homo sapiens
Iron (Fe) uptake, storage, redistribution, and recycling are highly regulated iron homeostasis
cross-talk between the vacuolar and plastidial seed compartments for iron store allocation was studied in various genetic backgrounds affecting iron homeostasis of both compartments Arabidopsis thaliana
(ATFER2, FER2, AT3G11050) accumulation at the late developmental stages of the fruit requires functional vacuolar iron efflux transport system in the seed Arabidopsis thaliana
mir T-DNA knockout rice mutant shows significantly impaired growth when grown under iron-deficient conditions Oryza sativa
mir plants accumulated more than twice the amount of iron in root tissue Oryza sativa
mir plants accumulated more iron when grown under iron-deficient conditions Oryza sativa
WT plants grown under Fe-sufficient conditions
high iron treatment represses (BHLH038, bHLH38, ORG2, AT3G56970) Arabidopsis thaliana
high iron treatment represses (BHLH101, AT5G04150) Arabidopsis thaliana
iron uptake from the soil is tightly regulated to allow optimal growth and development Arabidopsis thaliana
(ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) exhibits Michaelis-Menten kinetics for Fe2+ oxidation Arabidopsis thaliana
site-directed mutagenesis and ferroxidase assays confirmed acidic triad (E269, D370, and D462) for Fe2+-binding Arabidopsis thaliana; Nicotiana benthamiana
E3 ubiquitin ligase may posttranslationally control components of the transcriptional regulatory network involved in the iron deficiency response Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) does not interact with (PYE, AT3G47640) Nicotiana benthamiana
(BTS, EMB2454, AT3G18290) and its target (bHLH, AT5G51780) transcription factors will elucidate function in plant iron homeostasis signaling network Arabidopsis thaliana
Iron-Regulated Proteins ( (IRP1, AT3G07170) (AtLa1, IRP2, La1, AT4G32720) (IRP4, MEE34, AT3G11270) (ATDRH1, DRH1, IRP6, RH14, AT3G01540) ) are upregulated in (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant Arabidopsis thaliana
(HTB4, AT5G59910) mutation-induced changes in Fe deficiency-responsive (bHLH, AT5G51780) TF expression resulted in decrease in endogenous iron (Fe) levels
(bHLH104, AT4G14410) positively regulates expression of FIT Arabidopsis thaliana
(HTB4, AT5G59910) expression is proposed to be under the control of clade Ib bHLHs Arabidopsis thaliana
genes with decreased expression in (HTB4, AT5G59910) mutant compared to wild-type plants include (FEP2, IMA2, AT1G47395) (IRONMAN 2 FE-UPTAKE-INDUCING PEPTIDE 2) Arabidopsis thaliana
(AtVTL2, VTL2, AT1G76800) and (AtVTL5, VTL5, AT3G25190) are proposed to participate in maintenance of Fe homeostasis in planta Arabidopsis thaliana
(ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) is unable to oxidize 2,2′-azino-bis[3-ethylbenzothiazoline-6-sulfonic acid] (ABTS) Arabidopsis thaliana
reduced (ATIRT1, IRT1, AT4G19690) protein levels could be rate-limiting step for iron uptake in (BTS, EMB2454, AT3G18290) mutants Arabidopsis thaliana
elevated rhizosphere acidification, iron reductase activity, and iron uptake results in increased growth of (BTS, EMB2454, AT3G18290) mutants under low iron Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) ΔHHE (BBΔHG) complemented bts-1 lines by restoring iron reductase activity Arabidopsis thaliana
ferritin protein levels are decreased in (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) mutant Arabidopsis thaliana
Arabidopsis IRON-REGULATED TRANSPORTER1 encodes metal transporter Arabidopsis thaliana
Fe chelation by citrate and nicotianamine facilitates Fe transport
functional heterodimer of (bHLH105, ILR3, AT5G54680) and (bHLH115, AT1G51070) with (PYE, AT3G47640) facilitates iron deficiency response Arabidopsis thaliana
mitochondria are protected from iron deficiency Arabidopsis thaliana
PDR2-dependent compensatory processes are primed in low-Fe condition Arabidopsis thaliana
(ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) and (LPR2, AT1G71040) influence growth in P deprived roots through effects on Fe accumulation in root meristem and elongation zone Arabidopsis thaliana
(ATIRT1, IRT1, AT4G19690) is Fe-deficiency responsive gene Arabidopsis thaliana
excess Fe in the medium can elevate normal shoot Fe level Arabidopsis thaliana
wild-type Arabidopsis line was analyzed in parallel proteomic and transcriptomic study Arabidopsis thaliana
Fe supplementation reverses chlorosis in LC5 Oryza sativa
FIT acts as central regulator of Fe acquisition Arabidopsis
ethylene induces expression of OsNAS1 Oryza sativa
insensitive (ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) mutations prevent Fe accumulation in root tips Arabidopsis thaliana
trivalent cations (Fe3+, Al3+, and Ga3+) are not effective inhibitors of (ASA1, BIG, CRM1, DOC1, LPR1, TIR3, UMB1, AT3G02260) Arabidopsis thaliana
(ATVIT1, VIT1, AT2G01770) mutant does not show decrease in ferritin abundance
expression of (ATNRAMP3, NRAMP3, AT2G23150) or (ATNRAMP4, NRAMP4, AT5G67330) alone could rescue hypersensitivity to low-iron conditions in nramp3nramp4 double mutants Arabidopsis thaliana
(ATNRAMP3, NRAMP3, AT2G23150) is up-regulated under iron deficiency Arabidopsis thaliana
(ATOPT3, OPT3, AT4G16370) mediates long-distance signaling between shoots and roots Arabidopsis thaliana
Fe transporter (ATIRT1, IRT1, AT4G19690) downregulation avoids Fe toxicity Oryza sativa
(HTB4, AT5G59910) is Fe responsive Arabidopsis thaliana
(HTB4, AT5G59910) mutant plants under Fe deficiency conditions shows decreased induction of (ATIRT1, IRT1, AT4G19690) expression Arabidopsis thaliana
(H2B, HTB9, AT3G45980) does not show evident enrichment at TSSs of (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) genes Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) is expressed in root vasculature Arabidopsis thaliana
(ATFER4, FER4, AT2G40300) expression is decreased in 1-day-old and 3-day-old (ATNRAMP3, NRAMP3, AT2G23150) (ATNRAMP4, NRAMP4, AT5G67330) plants Arabidopsis thaliana
insufficient Fe in soil or growth medium limits symbiotic nitrogen fixation (SNF)
(ATIRT2, IRT2, AT4G19680) mediates Fe influx into cortical vesicles Arabidopsis thaliana
(AtTic21, CIA5, PIC1, TIC21, AT2G15290) mediates Fe influx to chloroplasts
Iron (Fe) must be transported into and exported from vacuoles
Fe deficiency induces expression of BRUTUS (BTS, EMB2454, AT3G18290) Arabidopsis thaliana
downregulated genes in (HTB4, AT5G59910) mutant are involved in response to iron ion Arabidopsis thaliana
poplar mutants showed significantly up-regulated iron deficiency response in roots Populus trichocarpa
Ib (bHLH, AT5G51780) TFs ( (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) ) are regulated by upstream IVc (bHLH, AT5G51780) TFs (bHLH034, (bHLH104, AT4G14410) (bHLH105, ILR3, AT5G54680) , and (bHLH115, AT1G51070) ) and (bHLH121, URI, AT3G19860) Arabidopsis thaliana
TSS enrichment in (BHLH038, bHLH38, ORG2, AT3G56970) (BHLH039, bHLH39, ORG3, AT3G56980) (BHLH100, AT2G41240) and (BHLH101, AT5G04150) genes is (HTB4, AT5G59910) specific Arabidopsis thaliana
loss of (ATIRT1, IRT1, AT4G19690) function results in reduced leaf iron content Arabidopsis thaliana
17 different (bHLH, AT5G51780) proteins from six clades regulate iron homeostasis Arabidopsis thaliana
(bHLH34, IDT1, AT3G23210) (iron deficiency tolerant 1) positively regulates expression of FIT Arabidopsis thaliana
(BTS, EMB2454, AT3G18290) E3 ubiquitin ligase promotes ubiquitin-mediated degradation via the 26S proteasome of (bHLH105, ILR3, AT5G54680) and (bHLH115, AT1G51070) Arabidopsis thaliana
iron-regulated transporter (ATIRT1, IRT1, AT4G19690) mediates uptake of Fe 2+
phosphorylated HA-FIT present in roots of Fe-sufficient and Fe-deficient plants
FIT-GFP / fit plants express constitutively FIT-GFP protein
FIT-GFP fusion can fully rescue Fe-deficient phenotype of fit plants
embryonic Fe accumulation conferred by decreased INNER NO OUTER (INO, AT1G23420) expression is rescued by (ATNRAMP1, NRAMP1, PMIT1, AT1G80830) loss-of-function mutation Arabidopsis thaliana
(CDI, AT1G64980) responsiveness to Fe deficiency leads to hypothesis that (CDI, AT1G64980) might actively modulate Fe homeostasis Arabidopsis thaliana
Pro bHLH100:bHLH104-GFP plants displayed slight tolerance to Fe deficiency Arabidopsis thaliana
TaZIPs heterologously expressed in fet3/fet4 Fe-uptake mutant strain were unable to rescue Fe-deficient phenotype Saccharomyces cerevisiae
(FEP2, IMA2, AT1G47395) (IRONMAN 2 FE-UPTAKE-INDUCING PEPTIDE 2) and (FEP1, IMA3, AT2G30766) encode peptides that are positive regulators of the iron deficiency response Arabidopsis thaliana
(bHLH121, URI, AT3G19860) (UPSTREAM REGULATOR OF (ATIRT1, IRT1, AT4G19690) ) positively regulates expression of FIT Arabidopsis thaliana
(HTB4, AT5G59910) mutation affected expression of genes encoding iron (Fe) deficiency-responsive (bHLH, AT5G51780) transcription factors (TFs)