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fatty acid biosynthesis

9617 relationships annotated with this phrase. Showing first 500 of 9617.
Source entity Relationship Target entity Species
2-oxoglutarate is partially used for fatty acid biosynthesis Glycine max
malic enzyme and pyruvate dehydrogenase activities in plastids produce one NADPH, one NADH, and one acetyl-CoA molecule
acyl-ACP pools were examined to assess whether additional supply of carbon from malate could trigger a new bottleneck at the point of fatty acid synthesis Glycine max
C14 (ACP, ACP1, AtACP1, AT3G05020) is the longest acyl-ACP without a chain-specific thioesterase in soybean Glycine max
NADPH-producing malic enzyme (ME) and pyruvate dehydrogenase complex (PDH) deliver stoichiometric amounts of acetyl-CoA Glycine max
acyl-ACPs are located to a lesser extent in mitochondria of plants
malic enzyme activity produces lipid carbon from glutamine Glycine max
absence of an HFA-specific TAG lipase reduced carbon availability leads to reduced FA synthesis
AtME4 transgenic allele provides balanced supply of carbon and reducing equivalents Glycine max
Tsu-0 allele promotes (ACC2, AT1G36180) function Arabidopsis thaliana
rate of FA synthesis in developing (cL37, PSRP5, AT3G56910) is reduced by 45% compared with (FAE1, KCS18, AT4G34520) parent at 4 DAS
fatty acid biosynthesis utilizes reducing equivalents
acyl-acyl carrier protein (ACPs) levels were quantified over development Glycine max
R6 stage of development showed larger accumulation of C14 (ACP, ACP1, AtACP1, AT3G05020) Glycine max
fatty acid biosynthesis appeared at 28 dpi
increasing malic enzyme activity may push carbon into fatty acid synthesis Glycine max
flux studies of wild-type soybean seed metabolism indicated that malic enzyme, not (PCK2, PEPCK, AT5G65690) supported fatty acid biosynthesis Glycine max
(ACP, ACP1, AtACP1, AT3G05020) levels did not differ significantly between events Glycine max
fatty acids (FAs) are exclusively synthesized in stroma of chloroplasts
(ACCD, ATCG00500) gene in Arabidopsis encodes one subunit of the chloroplast-localized heteromeric acetyl-coenzyme A carboxylase (ACCase) Arabidopsis thaliana
fatty acid biosynthesis is essential
fatty acid concentrations in transgenic tobacco and tomato plants expressing ShMKS2 either did not decrease or decreased only slightly Nicotiana tabacum; Solanum lycopersicum
CARB1 gene catalyzes first committing step in FA synthesis Chlamydomonas reinhardtii
levels of ATP and FFA in (ATVPS34, PI3K, VPS34, AT1G60490) KD suggest that the direction of carbon flux is toward FFA biosynthesis Chlamydomonas reinhardtii
common herbicides target novel enzyme Poaceae
heteromeric acetyl-coenzyme A carboxylase can function instead of functional (ACC2, AT1G36180) protein Arabidopsis thaliana
transgenic plants constitutively expressing ShMKS2 with or without ShMKS1 had trace amounts of myristic acid Arabidopsis thaliana; Nicotiana tabacum; Solanum lycopersicum
expressing a short-chain thioesterase in the alga Phaeodactylum tricornutum led to simultaneous increase in total fatty acids and decrease in growth rate Phaeodactylum tricornutum
(AtLEC1, EMB 212, EMB212, LEC1, NF-YB9, AT1G21970) plays a significant role in promoting fatty acid biosynthetic genes associated with seed maturation
Solanum habrochaites methylketone synthase2 (ShMKS2) hydrolyzes β-ketoacyl acyl-carrier protein Solanum habrochaites
difference in rates of methylketone synthesis between Arabidopsis and tobacco might be a result of tobacco seedlings having a higher fatty acid flux rate Arabidopsis thaliana; Nicotiana tabacum
mutant line accumulates TAG by FA biosynthesis bypassing TCA cycle Chlamydomonas reinhardtii
acetyl-coenzyme A carboxylase (ACCase) catalyzes conversion of acetyl-CoA to malonyl-CoA Arabidopsis thaliana
(ATVPS34, PI3K, VPS34, AT1G60490) knockdown line under nitrogen starvation initiates de novo fatty acid biosynthesis Chlamydomonas reinhardtii
(BADC3, BLP2, AT3G15690) mutant shows smaller increase in seed fatty acid content relative to wild type Arabidopsis thaliana
(BADC1, BLP3, AT3G56130) (BADC2, BLP1, AT1G52670) double mutant seeds show fatty acid increases of 15% to 30% Arabidopsis thaliana
de novo fatty acid synthesis occurs inside chloroplasts Nannochloropsis oceanica
conversion of carbon sources into acetyl-CoA differs in plastids from different plant tissues and species
RubisCO bypass reaction produces TPS
expression patterns of Chr4.2307.KCS, Chr4.2308.KCS, and Chr4.2311.KCS suggested these three genes are critically important in lipid metabolism and might be mainly responsible for regulating nervonic acid biosynthesis in Acer truncatum Acer truncatum
ShMKS2 is thioesterase
fatty acid biosynthesis-related genes are highly expressed primarily at 21 days after flowering (DAF) Brassica napus
overexpression of ω3 fatty acid desaturases (AtFAD3, FAD3, AT2G29980) and (AtFAD7, FAD7, FADD, AT3G11170) increases α-linolenic acid levels (18:3) Nicotiana tabacum
low levels of myristic acid were found in trichomes of wild tomato (accession no. PI126449) Solanum habrochaites
phenotypes observed in ShMKS2-expressing plants are consistent with interference with fatty acid biosynthesis Arabidopsis thaliana; Nicotiana tabacum; Solanum lycopersicum
EcCPS expression results in higher accumulation of CPA than plant (ABC33, ATCPS1, CPS, CPS1, GA1, AT4G02780) expression
down-regulation of key TCA cycle genes, including (PCK1, PEPCK, AT4G37870) results in TAG accumulation by FA biosynthesis bypassing TCA cycle Chlamydomonas reinhardtii
DG2 and PD1a recovered FA synthesis by 55% and 56% compared with (cL37, PSRP5, AT3G56910)
auxotrophic mutants unable to produce biotin result in embryo lethality Arabidopsis thaliana
genes in black module were positively related to nervonic acid biosynthesis (P < 0.09) Acer truncatum
STEAROYL-ACYL CARRIER PROTEIN Δ9-DESATURASE (SAD) initiates biosynthesis of polyunsaturated fatty acids (PUFAs)
not all fatty acids were equally affected Arabidopsis thaliana; Nicotiana tabacum; Solanum lycopersicum
ShMKS2 is also capable of hydrolyzing fully reduced myristoyl-acyl-carrier protein
majority of FA biosynthesis genes were upregulated in T411–N compared to WT–N Chlamydomonas reinhardtii
phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are important for producing 20:5 that is incorporated into chloroplast membrane Nannochloropsis oceanica
successful engineering of tomato trichomal methylketone production might require increases in metabolic flux toward fatty acid biosynthetic pathway in trichomes Solanum lycopersicum
Arabidopsis acyl-acyl-carrier protein thioesterase (FATB, AT1G08510) mutant displays growth retardation, variegated leaves, and reduced fertility Arabidopsis thaliana
similar expression profiles of auxin biosynthesis-related genes and Type I or II fatty acid synthesis-related genes indicate important roles of auxin in fatty acid (FA) biosynthesis Arabidopsis thaliana
fatty acid concentrations in transgenic Arabidopsis plants expressing ShMKS2 increased in general Arabidopsis thaliana
acetyl-CoA carboxylase and fatty acid synthase are critical for fatty acid biosynthesis Chlamydomonas reinhardtii
three other subunits of acetyl-coenzyme A carboxylase (ACCase) are encoded by nuclear genes Arabidopsis thaliana
constitutive expression of ShMKS2, either with or without ShMKS1, in transgenic cultivated tomato led to myristic acid accumulation in planta Solanum lycopersicum
34 genes predicted to affect elongation cycle include three genes encoding (ATTSC13, CER10, ECR, GLH6, TSC13, AT3G55360) two encoding HCD, one encoding KCR, and 28 encoding KCS Acer truncatum
Nossen allele decreases (ACC2, AT1G36180) function Arabidopsis thaliana
S. foetida accumulates sterculic acid equally at all sn-positions Sterculia foetida
ER-localized phosphatidylcholine (PC) has been proposed to contribute to 20:5 biosynthesis Nannochloropsis oceanica
heterologous expression of E. coli (ABC33, ATCPS1, CPS, CPS1, GA1, AT4G02780) resulted in accumulation of approximately 5.0% cyclopropane fatty acid (CPA) in primary transformants Arabidopsis thaliana
fatty acid biosynthesis is conserved between Brassica napus and Arabidopsis thaliana Brassica napus; Arabidopsis thaliana
different regulation of auxin and jasmonic acid (JA) in fatty acid (FA) biosynthesis is indicated by dissimilar altered fatty acid component patterns between axr2-1 and axr1-3 or (COI1, AT2G39940) mutants Arabidopsis thaliana
pyruvate is able to support fatty acid biosynthesis
malate is able to support fatty acid biosynthesis
PCR-positive transformants revealed elevated levels of 16:1n7 compared with wild type Phaeodactylum tricornutum
repression or loss of (NTT, WIP2, AT3G57670) activity results in dramatically decreased lipids in oil-storing Arabidopsis seeds Arabidopsis thaliana
reduced oil content (OC) may be due to impairment of fatty acid (FA) synthesis
distinct plastidial transport processes are required fatty acid biosynthesis
fatty acid biosynthesis utilizes ATP
expression level trends of Chr4.2308.KCS, Chr4.2307.KCS, and Chr4.2311.KCS were generally consistent with accumulation of nervonic acid (NA) Acer truncatum
PbGPAT5 (accession number 103942961) transcript levels are significantly higher in rainfall-treated russet and semi-russet fruit than in control fruit Pyrus × bretschneideri
FADX catalyzes conversion of linoleic acid to α-ESA (alpha-eleostearic acid)
efforts to engineer seeds of crop and model plant species have met with only modest success production of unusual fatty acids
acyl groups attached to (ACP, ACP1, AtACP1, AT3G05020) can be characterized via mass spectrometry
(GLC, AT1G65450) 6-P is imported by (GPT, AT2G41490)
fatty acid biosynthesis is completed via activities of fatty acid synthases, elongases, desaturases, and carboxylases
Acer truncatum genome has 34 genes predicted to affect four reactions of elongation cycle Acer truncatum
MYB transcription factors (TFs) have been found to play important roles in VLCFA biosynthesis
metabolic engineering enables expression of high levels of new fatty acids
AM fungi (AMF) lack genes encoding fatty acid synthase I subunits Glomeromycotina
PDH activity is low in leaves
ShMKS2 utilizes fatty acid biosynthetic intermediates and fatty acids
ER-localized phosphatidylethanolamine (PE) has been proposed to contribute to 20:5 biosynthesis Nannochloropsis oceanica
seed-specific co-expression of E. coli cyclopropane synthase with lysophosphatidic acid acyltransferase (LPAT) from Sterculia foetida seeds resulted in small increases in cyclopropane fatty acid accumulation Arabidopsis thaliana
protein conformations generated by (ACP, ACP1, AtACP1, AT3G05020) interactions influence chain flipping and thus catalytic outcomes Escherichia coli
acetate is assumed to be precursor for acetyl-CoA
enzymes mediate fatty acid biosynthesis
Brassica napus is subject of study for fatty acid metabolism Brassica napus
FA biosynthesis is divided into cytosolic glycolytic pathway, transport of carbon sources into plastids, starch metabolism, plastidic glycolytic pathway, plastidic OPPP, and FA synthesis pathway
conjugated fatty acid accumulation in Arabidopsis and soybean seeds engineered to express FAD2-related fatty acid conjugases previously noted for defective flux of acyl chains from PC to TAG Arabidopsis thaliana; Glycine max
(AtFAD2, FAD2, AT3G12120) and FADX are involved in total tung seed oil and α-ESA production Vernicia fordii
engineered seeds of crop and model plant species produce hydroxy and conjugated fatty acids
acyltransferases specialization of and possible arrangement in metabolons
(ACP, ACP1, AtACP1, AT3G05020) can interact in unique ways with wide variety of partners Escherichia coli
plants express long-chain polyunsaturated fatty acids
FAs is plastid localised fatty acid synthase
different enzymes specialized for fatty acid pathways requires determination of relative contributions in native species metabolic engineering of unusual fatty acids
Crambe seeds compared to other oilseeds including safflower (Carthamus tictorius) seeds are particularly effective at producing high levels of erucic acid due to low PDCT activity that effectively precludes exchange of fatty acids between DAG and PC Crambe abyssinica; Carthamus tictorius
genes encoding cytochrome P450 monooxygenase oxidoreductase (PbP45086A8, accession number 103957382) and fatty acid elongase (PbP45086B1, accession number 103943216) are significantly upregulated in semi-russet CG fruit compared to controls Pyrus × bretschneideri
metabolic bottleneck for flux of unusual fatty acids into TAG following their synthesis on PC is a major limitation for producing industrial fatty acids in engineered oilseeds
C16:0, C18:0 and C18:1 fatty acids are synthesized in plastids
α-ESA is produced and stored in tung tree seed endosperm
specialized castor bean PDCT activity is necessary for high level hydroxy fatty acid accumulation Arabidopsis thaliana
bryophyte metabolism exhibits very long-chain polyunsaturated fatty acids (vlcPFAs)
chromoplasts possess entire metabolic equipment for synthesis of 3-oxoacyl-ACP Solanum lycopersicum
unusual fatty acids are subject of biosynthesis studies
acetate is able to support fatty acid biosynthesis
acetate is activated inside chloroplast
OLEATE DESATURASE 1 (AtOLE1) expression upregulates fatty-acid biosynthesis Nicotiana benthamiana
heteromeric acetyl-CoA carboxylase (ACCase) and fatty acid synthase (FAS) results in acyl-ACP moieties that are 16 or 18 carbons long
(AtFaTA, FaTA, FATA1, AT3G25110) /B thioesterases produce free fatty acids
fatty acids synthesized in leucoplasts using acetate, pyruvate, and malate as substrates
Carboxyltransferase Interactor 1 (CTI1, AT1G42960) is an interactor of α-carboxyltransferase subunit of acetyl-CoA carboxylase (ACCase) Arabidopsis thaliana
3-oxoacyl-ACP is precursor of fatty acids Solanum lycopersicum
WRINKLED 1 (ASML1, ATWRI1, WRI, WRI1, AT3G54320) expression upregulates fatty-acid biosynthesis Nicotiana benthamiana
3-oxoacyl-ACP is precursor of fatty acids
fatty acid (FA) biosynthesis is important for increasing oil and fatty acid (FA) content Zea mays mays
oilseeds provide platform for production of high-value fatty acids
Ado-Met provides methylene group used in biosynthesis of fatty acids
palmitic acid, stearic acid, and linoleic acid showed different percentages under rich light and canopy light tung tree seed oil composition
betaine lipid diacylglyceryl-N,N,N-trimethylhomoserine in pdh lines showed most noticeable alterations in increased proportion of palmitic acid 16:0 and decreased proportion of linoleic acid 18:2 Δ9,12 Chlamydomonas reinhardtii
CaMV35S:FAE1 transgenic Arabidopsis plants can accumulate high levels (>30%) of very-long-chain fatty acids (VLCFAs) in leaf membrane lipids Arabidopsis thaliana
peroxygenase encoded by SGN-U567002 is involved in formation of 9,12,13-trihydroxy-10(E)-octadecenoic acid Solanum lycopersicum
light affects fatty acid synthesis
acetyl-CoA is converted to malonyl-CoA precursors by acetyl-CoA carboxylase (ACCase) Haematococcus pluvialis
TET strongly represses accumulation of 9,12,13-trihydroxy-10(E)-octadecenoic acid Solanum lycopersicum
malonyl-CoA:ACP transacylase (EMB3147, MCAMT, MCAT, AT2G30200) reaction forms malonyl-ACP Haematococcus pluvialis
expression levels of ACCase, (EMB3147, MCAMT, MCAT, AT2G30200) KAS II, III, HD, and SACPD were similar between haematocysts and macrozooids Haematococcus pluvialis
mitochondrial activity in SUL is possibly directed into mitochondrial fatty acid formation Solanum tuberosum
(ACBP4, AtACBP4, AT3G05420) and (ACBP5, AtACBP5, AT5G27630) could participate in transfer of oleoyl-CoA esters to the endoplasmic reticulum (ER) from the chloroplasts Arabidopsis thaliana
H. pluvialis actively synthesized fatty acids de novo—mainly oleic, palmitic, and linoleic acids Haematococcus pluvialis
NADPH-producing malic enzyme (ME) and pyruvate dehydrogenase complex (PDH) deliver stoichiometric amounts of NADH Glycine max
short time frame during which transport of the essential co-factor biotin across the embryo epidermis is catalysed by (ATSUC5, SUC5, AT1G71890) is sufficient for proper fatty acid synthesis Arabidopsis thaliana
levels of KAR and KAS I transcripts were increased to the greatest degree (2.75- and 3.5-fold, respectively) in response to conditions of high light Haematococcus pluvialis
acetyl CoA carboxylase catalyzes fatty acid biosynthesis
malic enzyme is the source of pyruvate Glycine max
microalgal lipid metabolism involves carbon allocation to fatty acid (FA) synthesis
termination of elongation can be mediated either by an acyl-ACP thioesterase (FAT)—resulting in free fatty acid release and export to the cytosol—or by direct transfer of the acyl group to glycerol-3-phosphate and/or monacylglycerol-3-phosphate in the TAG biosynthetic pathway Haematococcus pluvialis
fatty acid elongase 1 (FAE1, KCS18, AT4G34520) catalyses the production of C20+ very-long-chain saturated and mono-unsaturated fatty acids (VLCFAs) Arabidopsis thaliana
pdh lines produced 45–75% less volumetric total fatty acid than control lines in HSM-N Chlamydomonas reinhardtii
pdh lines had total fatty acid production unaltered in mixotrophic nitrogen-depleted cultures compared with control Chlamydomonas reinhardtii
cpPDC is at least one control point in supply of acetyl-CoA for de novo FA synthesis
heterotrophic growth in the absence of chloroplast translation is enhanced by genetic modifiers present in the most tolerant accessions Arabidopsis thaliana
DG2 and PD1a did not achieve FA synthesis levels similar to (FAE1, KCS18, AT4G34520)
biotin is required for ACCase function Arabidopsis thaliana
(BADC1, BLP3, AT3G56130) (BADC3, BLP2, AT3G15690) double mutant seeds show fatty acid increases of 18% to 30% Arabidopsis thaliana
heterologous expression of S. foetida (ABC33, ATCPS1, CPS, CPS1, GA1, AT4G02780) resulted in accumulation of detectable cyclopropane fatty acid (CPA) Arabidopsis thaliana
T411 mutant line diverts carbon via enhanced glycolysis for FFA synthesis Chlamydomonas reinhardtii
Rhizophagus irregularis lacks gene encoding multidomain fatty acid de novo synthase Rhizophagus irregularis
PDC2_E1α silencing resulted in about 20% lower total fatty acid content in pdh72 after 6 days photoautotrophic growth Chlamydomonas reinhardtii
pdh mutants demonstrated 25–40% less volumetric total fatty acid production than control lines Chlamydomonas reinhardtii
FAs are synthesized in plastids
(ATMYB118, MYB118, PGA37, AT3G27785) is essential for biosynthesis of omega-7 monounsaturated fatty acids Arabidopsis thaliana
Arabidopsis thaliana mutants lacking WRINKLED1 (ASML1, ATWRI1, WRI, WRI1, AT3G54320) show restoration of oil content with respective orthologs from maize Arabidopsis thaliana; Zea mays
fad3-2 mutant is impaired in α-linolenic acid biosynthesis Arabidopsis thaliana
fad2fae1 Arabidopsis seeds contain 18:1 at approximately 84% of total fatty acid Arabidopsis thaliana
3-ketoacyl-ACP synthase gene has approximately two copies in plastids Brassica napus
IgASE1 expression leads to production of EDA and ETrA Arabidopsis thaliana
pdh lines demonstrated severe impairment of total fatty acid production in HSM-N Chlamydomonas reinhardtii
reduction in SUC5-driven sucrose import results in reduced availability of organic carbon for fatty acid biosynthesis Arabidopsis thaliana
tissue-specific enrichment in capacity for 18:1 formation and export from plastids appears to be higher in cotyledons at transcriptional level Brassica napus
same unusual fatty acid in seed oils can be achieved by action of evolutionary unrelated enzymes
suppressed CsFAD3 expression resulted in lower levels of 18:3 accumulation Camelina sativa
acyl-ACP chain is successively elongated by a subsequent series of condensation reactions catalysed by 3-ketoacyl-ACP-synthase (KAS), 3-ketoacyl-ACP-reductase (KAR), 3-hydroxyacyl-ACP dehydratase (HD), and enoyl-AC reductase (ENR) Haematococcus pluvialis
Acer truncatum KCS gene family expanded to 28 genes Acer truncatum
successful engineering of tomato trichomal methylketone production might require introducing wild tomato fatty acid biosynthesis gene loci Solanum lycopersicum; Solanum habrochaites
up-regulation of most genes involved in the FA biosynthetic pathway suggests that the direction of carbon flux is toward FFA biosynthesis Chlamydomonas reinhardtii
ferredoxin (Fd) is involved in fatty acid biosynthesis
fatty acid biosynthesis occurs in chloroplast
oleoyl chains are produced within chloroplast
unusual fatty acids with epoxy and hydroxy groups, triple bonds and conjugated double bonds are synthesized from enzymes that have evolved from an ancestral Δ12 fatty acid desaturase
lower levels of 18:3 accumulation in miR167OE seeds Camelina sativa
seed-specific expression of RNAi constructs targeting the three B. napus FAD2 genes allow for maintenance of wild-type levels of polyunsaturated fatty acids in non-seed tissues Brassica napus
acetyl-CoA, NADH, and NADPH power two-carbon elongation of fatty acid chain in plastid Glycine max
pyruvate is the precursor of acetyl-CoA Glycine max
ACPs as a class increase during fatty acid biosynthesis Glycine max
AtME4 events results in enhanced levels of oleic acid Glycine max
(ACC2, AT1G36180) protein participates in fatty acid biosynthesis Arabidopsis thaliana
cerulenin forms covalent bond with catalytic cysteine of fatty acid synthase
very-long-chain fatty acid (VLCFA)-derivatives are obtained from plastidial fatty acid de novo biosynthesis
68 genes important for VLCFA biosynthesis pathway were identified in Acer truncatum Acer truncatum
Camelina sativa derived fatty acid desaturase 3 overexpression (CsFAD3-OE) Arabidopsis line accumulated high levels of α-linolenic acid (ALA) Arabidopsis thaliana
NADPH-producing malic enzyme (ME) and pyruvate dehydrogenase complex (PDH) deliver stoichiometric amounts of NADPH Glycine max
labeling in pyruvate but not in (PAS2, PEP, PEPINO, AT5G10480) from LC–MS/MS analysis of U-13C glutamine cultured soybeans supported malic enzyme, not (PCK2, PEPCK, AT5G65690) supported fatty acid biosynthesis Glycine max
acyl-ACPs are located in chloroplast
C14 (ACP, ACP1, AtACP1, AT3G05020) accumulation possibly results from increased nonspecific (AtFaTA, FaTA, FATA1, AT3G25110) /B thioesterase activity Glycine max
(ACP, ACP1, AtACP1, AT3G05020) profile observed in soybeans differs from other reports Glycine max
measured increase in lipid in soybeans does not require changes to fatty acid biosynthetic machinery Glycine max
KASII drives conversion of 16:0-ACP to 18:0-ACP Camelina sativa
many fungi (e.g. Saccharomyces cerevisiae or Aspergillus nidulans) have enzymatic domains of FAS distributed to two polypeptides (α and β subunits, type A FAS) Saccharomyces cerevisiae; Aspergillus nidulans
genetic engineering enables generation of unique oils in commodity crops Glycine max
altered expression of genes involved in flavonoid and fatty acid biosynthesis results in notable increases of linoleic acid (C18:2) Brassica napus
plastidial pyruvate dehydrogenase (PDH) catalyzes decarboxylation of pyruvate
de novo fatty acid biosynthesis is localized in chloroplasts
MYB and (AtbZIP, bZIP, AT1G68880) transcription factors (TFs) participate in regulating synthesis of fatty acids
enhancement of expression/activity of KASII could increase 18:1-ACP/18:1-CoA pools for further desaturation Camelina sativa
di-hydroxy fatty acids has described biosynthetic pathway
levels of enzymes involved in fatty acid synthesis are unchanged in (ICL, AT3G21720) mutant Chlamydomonas
transient decrease in fatty acid content in (ATSUC5, SUC5, AT1G71890) mutants at 8 DAF coincides with onset of fatty acid biosynthesis Arabidopsis thaliana
mammals contain single FAS polypeptide of about 2500 amino acids (type I FAS)
type II mitochondrial FAS consists of individual polypeptides including separate acyl carrier protein (ACP, ACP1, AtACP1, AT3G05020)
(AtFAD3, FAD3, AT2G29980) expression levels corresponded to 18:3 accumulation Arabidopsis thaliana
(ATMYB118, MYB118, PGA37, AT3G27785) regulates transcription of (AAD2, AT3G02610) and (AAD3, AT5G16230) Arabidopsis thaliana
soybean events carrying only the Delta(15) desaturase possessed significant elevation of alpha-linolenic acid (ALA) content Glycine max
some fungi (Laccaria bicolor, Ustilago maydis) contain single polypeptide FAS analogous to animals (type B1 FAS) Laccaria bicolor; Ustilago maydis
Brassicaceae accumulate very long chain fatty acids
(AP2, AtAP2, FL1, FLO2, AT4G36920) /EREB targets are involved in biosynthesis of FAS Zea mays
cpPDC is at least one control point in supply of acetyl-CoA for de novo FA synthesis in the plastids of C. reinhardtii Chlamydomonas reinhardtii
lack of biotin in the embryo may cause transient decrease in fatty acid content in (ATSUC5, SUC5, AT1G71890) mutants at 8 DAF Arabidopsis thaliana
imported sugars and amino acids are converted to fatty acids Glycine max
pyruvate dehydrogenase is linked specifically to fatty acyl chain biosynthesis Glycine max
(CTI1, AT1G42960) interaction with ACCase mediates docking of ACCase to the plastid envelope membrane Arabidopsis thaliana
α-ESA under canopy light remained at <50% until very near the end of seed development
conversion of acetyl-CoA to malonyl-CoA during fatty acid biosynthesis within the plastid is required for embryo development in Arabidopsis Arabidopsis thaliana
heterotrophic growth in the absence of chloroplast translation is mediated by (ACC2, AT1G36180) Arabidopsis thaliana
function of ShMKS2 is thioesterase utilizing fatty acid biosynthesis intermediates
homozygous T3 seeds expressing EcCPS accumulated approximately twice as much cyclopropane fatty acid (CPA) compared to hemizygous T1 seeds Arabidopsis thaliana
enrichment of cyclopropane fatty acid (CPA) at both sn-1 and sn-2 positions of phosphatidylcholine (PC) increases accumulation of cyclopropane fatty acid (CPA)
malvic acid in S. foetida is present at only 3% at sn-2 position Sterculia foetida
(BADC1, BLP3, AT3G56130) knockout results in significant increase in seed fatty acid content as percentage dry weight Arabidopsis thaliana
α-ESA is also produced in developing seed cotyledons
phosphatidylcholine is the site of hydroxy fatty acid biosynthesis
GmSACPD-A, GmSACPD-B, and GmSACPD-D mutants have lower stearic acid content (4–7%) than Gmsacpd-c mutants Glycine max
ShMKS2 is mostly β-ketoacyl-acyl-carrier protein thioesterase preferring C14 substrate
flufenacet inhibits activity of very-long-chain fatty acid elongases
(ACC2, AT1G36180) targets homomeric acetyl-coenzyme A carboxylase (ACCase) Arabidopsis thaliana
(ACC2, AT1G36180) contributions to fatty acid biosynthesis impact on plant growth and development in natural environments Arabidopsis thaliana
AMPK inhibits fatty acid synthase Chlamydomonas reinhardtii
(BADC1, BLP3, AT3G56130) (BADC3, BLP2, AT3G15690) double mutant shows significant increase in fatty acid per seed Arabidopsis thaliana
enhancer and modifiers could lead to improved targeting of overexpressed homomeric acetyl-coenzyme A carboxylase to plastids in transgenic plants
model oilseeds are used for biosynthesis of modified fatty acids Arabidopsis thaliana
(BADC1, BLP3, AT3G56130) (BADC2, BLP1, AT1G52670) double mutant shows significantly elevated fatty acid dry weight Arabidopsis thaliana
fatty acids are synthesized in chloroplast
TAG accumulation through FA biosynthesis is highly energy-consuming process Chlamydomonas reinhardtii
crown galls produce increased levels of α-linolenic acid Arabidopsis thaliana
up-regulation of FA biosynthesis genes in T411–N substantiates higher FFA levels Chlamydomonas reinhardtii
(ATVPS34, PI3K, VPS34, AT1G60490) KD resulted in AMPK down-regulation and enhanced FA biosynthesis Chlamydomonas reinhardtii
RcFAH12 expression in (FAE1, KCS18, AT4G34520) mutant produces seeds with elevated 18:1 Arabidopsis thaliana
KAR (3-ketoacyl-ACP reductase) is part of plastid fatty acid synthase complex Physcomitrella patens
acetyl-CoA cannot cross plastid membrane
fatty acid (FA) biosynthesis is enriched in CsFAD3-OE embryos Camelina sativa
FD is required for fatty acid biosynthesis
Tree peony (Paeonia suffruticosa Andr.) has high proportion of ALA (more than 45% in seed oil) Paeonia suffruticosa
medium-chain and very-long-chain fatty acids are synthesized by variants of enzymes (thioesterases and fatty acid elongases) expressed in all plants
Crambe seed oil is naturally enriched in erucic acid (22:1; ∼60% of total oil) Crambe abyssinica
depletion of dioxygen limits de novo synthesis of unsaturated fatty acids (FAs)
acetyl-CoA generated from acetate in the medium was rerouted to FA biosynthesis under acute starvation conditions Chlamydomoans reinhardtii
pyruvate dehydrogenase (PDH) provides acetyl-CoA for fatty acid biosynthesis
disruption of (115D-4A, ACC1, AT-ACC1, EMB22, GK, GSD1, PAS3, SFR3, AT1G36160) gene in Arabidopsis ( GURKE, and PASTICCINO3 [ ]) results in embryo-defective phenotype distinct from that seen following a loss of chloroplast translation Arabidopsis thaliana
increases in methylketone production in plants may also require increasing flux of fatty acid biosynthesis
maximal levels of methylketones depends on presence of wild tomato alleles at fatty acid biosynthesis gene loci Solanum lycopersicum; Solanum habrochaites
morphological and developmental phenotypes of ShMKS2-expressing plants are quite similar to phenotypes of Arabidopsis mutants deficient in de novo fatty acid biosynthesis Arabidopsis thaliana
genetic modification of stearic acid biosynthesis pathway is more efficient in reducing trans-fats introduced by hydrogenation process Glycine max
homomeric acetyl-coenzyme A carboxylase (ACCase) localizes to plastids Arabidopsis thaliana
β-ketoacyl-acyl-carrier protein synthase1 mutant displays growth retardation, variegated leaves, and reduced fertility Arabidopsis thaliana
up-regulation of the gene encoding Pyruvate dehydrogenase, (PDC2, AT5G54960) confirms the direction of carbon flux toward FA biosynthesis Chlamydomonas reinhardtii
three additional genes ( (LTA2, PLE2, AT3G25860) (EMB3003, AT1G34430) and (EMB3147, MCAMT, MCAT, AT2G30200) ) are associated with reactions that precede and follow the step catalyzed by heteromeric ACCase Arabidopsis thaliana
interference with fatty acid biosynthesis remains a possible explanation for lesions and delayed growth Arabidopsis thaliana; Nicotiana tabacum; Solanum lycopersicum
low temperature (15°C) facilitates accumulation of 20:5 Nannochloropsis oceanica
(115D-4A, ACC1, AT-ACC1, EMB22, GK, GSD1, PAS3, SFR3, AT1G36160) encodes essential protein localized to the cytosol Arabidopsis thaliana
(BADC2, BLP1, AT1G52670) mutant shows elevation in levels of fatty acid dry weight in seeds Arabidopsis thaliana
functional OPPP and dark regulation of (PRK, AT1G32060) in Vaucheria litorea plastids is essential for synthesis of NADPH for fatty acid biosynthesis Vaucheria litorea
heterologous expression of cotton (ABC33, ATCPS1, CPS, CPS1, GA1, AT4G02780) resulted in accumulation of detectable cyclopropane fatty acid (CPA) Arabidopsis thaliana
transcripts of several fatty acid biosynthesis genes are present at lower concentrations in trichomes of cultivated tomato Solanum lycopersicum; Solanum habrochaites
localization pattern of KAR in stromules indicates demand of fatty acid synthesis Physcomitrella patens
growth defects of transgenic Arabidopsis overexpressing ShMKS2 are likely a result of interruption of fatty acid biosynthesis Arabidopsis thaliana
current study showed potential effect of new isolated Gmsacpd mutants in increasing seed stearic acid content while maintaining healthy nodules Glycine max
fatty acid desaturase (AtFAD3, FAD3, AT2G29980) is primarily responsible for production of 18:3
bzip67 mutant seed contained lower 18:3 Arabidopsis thaliana
bryophytes have propensity for very long chain polyunsaturated fatty acid (vlcPFA) accumulation
disruptions of three additional genes ( (LTA2, PLE2, AT3G25860) (EMB3003, AT1G34430) and (EMB3147, MCAMT, MCAT, AT2G30200) ) result in embryo lethality Arabidopsis thaliana
constitutive expression of ShMKS2, either with or without ShMKS1, in transgenic Arabidopsis led to myristic acid accumulation in planta Arabidopsis thaliana
(ATVPS34, PI3K, VPS34, AT1G60490) KD showed enhanced/uninhibited FFA synthesis Chlamydomonas reinhardtii
unusual fatty acids are synthesized by enzymes that have evolved as variants of enzymes of membrane fatty acid metabolism
Crepis palaestina synthesizes vernolic acid from linoleic acid via a divergent (AtFAD2, FAD2, AT3G12120) desaturase-like enzyme Crepis palaestina
FAS1-like complexes have been suggested in oleaginous species Nannochloropsis oceanica and Nannochloropsis gaditana Nannochloropsis oceanica; Nannochloropsis gaditana
R5 seeds showed higher levels of short-chain ACPs Glycine max
mutations in the soy FAD2-1A and FAD2-1B genes has led to the production of high-oleic lines Glycine max
(ACC2, AT1G36180) may contribute to fatty acid biosynthesis in chloroplasts under selected conditions Arabidopsis thaliana
acetyl-CoA was partly directed toward FA synthesis Chlamydomonas reinhardtii
acyl carrier protein 1 (ACP, ACP1, AtACP1, AT3G05020) gene has 16 copies in plastids Brassica napus
transcript ratio similarity between 9 DAF and 20-32 DAF seeds indicates active fatty acid metabolism at 9 DAF Brassica napus
C18 fatty acids are produced through acetate pathway
fatty acid biosynthesis requires balanced supply of carbon and reducing equivalents
malic enzyme is linked specifically to fatty acyl chain biosynthesis Glycine max
(FATB, AT1G08510) transcripts were higher in EA tissues Brassica napus
metabolic rearrangement under HL versus LL conditions leads to enhanced de novo fatty acid biosynthesis Chlorella vulgaris
cytosolic fatty acid biosynthetic pathway is predicted pathway Chlorella vulgaris
deletion in GmSACPD-B resulted in high stearic acid content in seeds Glycine max
very long chain fatty acids (>C20) has described biosynthetic pathway
decreased 18:3 content corresponded to reduced CsFAD3 transcripts Camelina sativa
FAS1-like complexes have not yet been suggested in green lineage
nonsense mutations in GmSACPD-C increasing seed stearic acid content up to 20.7% Glycine max
epoxy fatty acids has described biosynthetic pathway
Crepis palaestina accumulates about 60% vernolic acid in its seed oil Crepis palaestina
relative enrichment of C18:1 acyl groups in cotyledonary tissues may in part be contributed from final steps in de novo FA biosynthesis in plastid Brassica napus
acetate pathway gets its substrate from acetyl-CoA
oleate desaturase (AtFAD2, FAD2, AT3G12120) gene modifications in biosynthesis of hydroxy fatty acids
animals and fungi possess FAS type I complexes (FAS1) located in cytosol
acetyl-coenzyme A carboxylase (ACCase) is essential enzyme in fatty acid biosynthesis Arabidopsis thaliana
expression of E. coli cyclopropane synthase (CPS) gene in fad2fae1 Arabidopsis results in accumulation of as much as 9.3% cyclopropane fatty acid (CPA) in Arabidopsis seeds Arabidopsis thaliana
AMPK inhibits acetyl-CoA carboxylase Chlamydomonas reinhardtii
(KAS1, KASI, AT5G46290) and (ATKAS2, FAB1, KAS2, AT1G74960) show unchanged levels in (ICL, AT3G21720) mutant Chlamydomonas
Q215W mutant (AtFaTA, FaTA, FATA1, AT3G25110) has higher catalytic efficiency compared to wild-type Helianthus annuus (AtFaTA, FaTA, FATA1, AT3G25110) Helianthus annuus
active starch metabolism at early stages of Brassica napus seed development is consistent with differential expression patterns of starch metabolism and OPPP-related genes Brassica napus
fatty acid biosynthesis is one of the major steps involved in production of complex oils
combined results of genomic, transcriptomic, cell ultrastructural, and gas chromatography–mass spectrometry analyses provided new insights regarding fatty acid biosynthesis pathway in Acer truncatum Acer truncatum
enzyme-encoding gene families related to lipid metabolism underwent more than three duplications (ATTSC13, CER10, ECR, GLH6, TSC13, AT3G55360) ER, HAD, KAR, SAD, LACS, and KCS Acer truncatum
acetyl-coenzyme A carboxylase D (ACCD, ATCG00500) underlies the requirement for chloroplast translation during heterotrophic growth and embryo development Arabidopsis thaliana
(ACC2, AT1G36180) might lack feedback regulation system described for heteromeric acetyl-coenzyme A carboxylase in the Brassicaceae Arabidopsis thaliana
fatty acid synthesis usually terminates with C16:0 or C18:0 products
fatty acid desaturase (FAD) is an Fd-dependent gene Fd-dependent metabolic pathway Oryza sativa
Gene Ontology (GO) term analysis of DEGs for upper versus lower epidermal cells revealed biological processes associated with photosynthesis, cuticle development, and fatty acid biosynthesis Arabidopsis thaliana
fatty acid synthase (FAS) functions in de-novo biosynthesis of fatty acids
ShMKS2 is capable of hydrolyzing myristoyl-acyl-carrier protein
active starch metabolism at early stages of Brassica napus seed development occurs before initiation of fatty acid biosynthesis Brassica napus
redox states of the chloroplast and (ATPRX Q, PRXQ, AT3G26060) connecting to 16:1t synthesis
plastidial acetate transporter has not been identified to date
de novo fatty acid biosynthesis requires reducing power
(GLC, AT1G65450) 6P is able to support fatty acid biosynthesis
(PAS2, PEP, PEPINO, AT5G10480) is able to support fatty acid biosynthesis
KCS gene is important for nervonic acid biosynthesis
nuclear gene encodes chloroplast-localized homomeric acetyl-coenzyme A carboxylase (ACCase) Poaceae
enoyl-acyl-carrier protein reductase mutant mosaic death1 displays growth retardation, variegated leaves, and reduced fertility Arabidopsis thaliana
lower oil content in HFA-accumulating lines provides one explanation for reduced FA synthesis
T-DNA insertions into (BADC1, BLP3, AT3G56130) (BADC2, BLP1, AT1G52670) and (BADC3, BLP2, AT3G15690) genes resulted in increased fatty acid accumulation in seeds Arabidopsis thaliana
α-ESA (alpha-eleostearic acid) accumulated to approximately 80% of oil component under rich light after 1 week of rapid oil accumulation tung seed oil
ACCase docking to the plastid envelope membrane attenuates fatty acid biosynthesis Arabidopsis thaliana
defective embryo shows inhibition of fatty acid synthesis Arabidopsis thaliana
MYB and (AtbZIP, bZIP, AT1G68880) transcription factors (TFs) were found to be involved in regulating nervonic acid biosynthesis Acer truncatum
beta-ketoacyl-ACP reductase catalyzes reduction of beta-ketoacyl-CoA to beta-hydroxyacyl-CoA
CsFAD3 might be subject to regulation by miR167A-CsARF8 mediated pathways Camelina sativa
enoyl-ACP reductase (ENR) gene has approximately two copies in plastids Brassica napus
histone acetylation might contribute to optimization of nutritional structure of edible oils through epigenetic engineering Arabidopsis thaliana
(HDA2, AT5G26040) mutant shows variation in total fatty acid content Arabidopsis thaliana
β-ketoacyl-ACP synthase (KAS) is involved in elongation of carbon chain from C4 to C18
3-oxyacyl- (ACP, ACP1, AtACP1, AT3G05020) reductase (KR), enoyl- reductase (ENR), and acyl carrier protein 1 genes have transcript ratio of KR:ENR:ACP = 1:1:8 Brassica napus
plastids are involved in fatty acid biosynthesis
3-oxyacyl- (ACP, ACP1, AtACP1, AT3G05020) reductase (KR), enoyl- reductase (ENR), and acyl carrier protein 1 genes is similar to transcript ratio of KR:ENR:ACP = 1:1.2:6.9 in seeds at 20-32 DAF Brassica napus
de novo fatty acid biosynthesis requires ATP
ATP and reducing equivalents are generated by substrate-level phosphorylation
cultured Arabidopsis embryos show decrease in long chain fatty acid accumulation
(ATX4, SDG16, AT4G27910) mutant shows variation in total fatty acid content Arabidopsis thaliana
constitutive expression of (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) in wild-type plants increased ALA/LA ratio Arabidopsis thaliana
ONI1 and ONI2 encode homologs of FA condensing enzymes Oryza sativa
genes encoding the FA condensing enzymes include large number of homologs (around 20 or more homologous sequences have been identified in the genome of rice and other plants) Oryza sativa
(AtFAP1, FAP1, AT3G63170) is FA-binding protein which localizes in plastid stroma
GRMZM5G853065 encodes fatty acid synthase (FAS, EC: 2.3.1.85) Zea mays
de novo fatty acid biosynthesis is localized in non-green plastids
(FAD4, FADA, AT4G27030) mutant was first discovered through screen for changes in total leaf FA composition Arabidopsis thaliana
3-oxyacyl-ACP reductase (KR) gene has approximately two copies in plastids Brassica napus
lipid biosynthesis capacity in tomato chromoplast is attested by presence of all acetyl-CoA-carboxylase monomers Solanum lycopersicum
coexpression of EcCPS with SfLPAT suggests that substrate supply is not limiting for cyclopropane fatty acid (CPA) accumulation
(BADC2, BLP1, AT1G52670) mutant shows smaller increase in seed fatty acid content relative to wild type Arabidopsis thaliana
high-throughput sequencing of differentially expressed genes revealed altered expression of genes involved in fatty acid biosynthesis Brassica napus
expansion of resources through increased 0-HFA-TAG and common FA availability leads to greater FA synthesis and decreased retention of HFA in the polar lipid during establishment
desaturation and elongation of long-chain fatty acids proceed at endoplasmic reticulum (ER) membrane Nannochloropsis oceanica
cytosolic, homomeric ACCase is involved in later stages of fatty acid biosynthesis Arabidopsis thaliana; Brassica napus
acetyl-CoA synthase proteins are involved in early stages of de novo fatty acid biosynthesis Dunaliella bardawil
(BADC3, BLP2, AT3G15690) mutant shows significant increase in fatty acid per seed Arabidopsis thaliana
production of myristic acid was observed in all three plant species expressing ShMKS2 under the 35S promoter Arabidopsis thaliana; Nicotiana tabacum; Solanum lycopersicum
highly expressed seed isoform GmSACPD-C mutants at M6 generation were not able to recover and/or restore phenotype and showed greater than 21% stearic acid content Glycine max
mutations of histone methylation- or acetylation-related genes resulted in highly variable fatty acid (FA) contents and compositions Arabidopsis thaliana
NF-YB-1 is highly expressed in mesocarp and endosperm at stages when FAS gene transcription peaked Elaeis guineensis
KASII is the only gene that clearly opposed 16:0 Elaeis guineensis
low rates of FA synthesis results in high concentrations of (PAS2, PEP, PEPINO, AT5G10480) and 3-PGA
GRMZM2G120987 encodes fatty acyl carrier protein reductase (FAR2, MS2, AT3G11980) Zea mays
fatty acid synthase (FAS) catalyzes formation of 16:0 and 18:0 fatty acids
soft impact on GmSACPD-C protein activity subsequently resulting in slight increase in seed stearic acid (~7%) Glycine max
(BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) mutation decreases ratio of α-linolenic acid (ALA) to linoleic acid (LA) Arabidopsis thaliana
(AtFAD3, FAD3, AT2G29980) (LACS2, LRD2, AT1G49430) (ATLPP3, LPP3, AT3G02600) and PLAIII β are targets of (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) involved in fatty acid synthesis Arabidopsis thaliana
(BCCP2, CAC1-B, AT5G15530) is downregulated in wri4-1 mutant stems Arabidopsis thaliana
ZFP-1 is linked to 10 guide genes Elaeis guineensis
(AtFAP3, FAP3, AT1G53520) was coexpressed with FAS genes in Arabidopsis Arabidopsis thaliana
(ATSUC5, SUC5, AT1G71890) mutants ( .1, .2 and .3) show transient decrease in total fatty acid content at 8 DAF Arabidopsis thaliana
(AtPPT1, HRL1, PPT1, AT4G23660) overexpression in wild-type Col-0 did not increase fatty acid content Arabidopsis thaliana
mutation in (ATX5, SDG29, SET29, AT5G53430) significantly increased total fatty acid (FA) content Arabidopsis thaliana
histone methylation might be involved in fatty acid (FA) biosynthesis Arabidopsis thaliana
(WRI4, AT1G79700) upregulates genes encoding enzymes associated with fatty acid biosynthesis Arabidopsis thaliana
substrate preferences of oil palm (AtFaTA, FaTA, FATA1, AT3G25110) and FATB1 and B2 isoforms remain unknown Elaeis guineensis
EgWRI1-1 is transcriptional enhancer of fatty acid biosynthesis genes Elaeis guineensis; Arabidopsis thaliana
transcripts for KASII were higher in cotyledons relative to EA tissues Brassica napus
fatty acid biosynthetic genes show differential expression between M+ and M− plants Medicago truncatula
stearoyl-ACP-desaturase gene has approximately two copies in plastids Brassica napus
genes involved in lipid and sugar metabolism are most linked to at least two of the three transcription factors Elaeis guineensis
LC-PUFAs engineered to economically viable levels in camelina seeds Camelina sativa
Arabidopsis (AtFAD2, FAD2, AT3G12120) (FAE1, KCS18, AT4G34520) mutant has high levels of oleic acid in seeds Arabidopsis thaliana
constitutive expression of ShMKS2, either with or without ShMKS1, in transgenic tobacco led to myristic acid accumulation in planta Nicotiana tabacum
constitutive down-regulation of ACCase by BADC supported by observation that rates of fatty acid synthesis in (BADC1, BLP3, AT3G56130) (BADC3, BLP2, AT3G15690) are 26% higher than wild-type Arabidopsis thaliana
Δ12 desaturases (AtFAD2, FAD2, AT3G12120) catalyzes production of unusual fatty acids
rate of fatty acid synthesis with malate as precursor approximately 4.5 and 120 times higher than rate of fatty acid synthesis with pyruvate and acetate as precursors
PbFAR3 (accession number 103931004) transcript levels are significantly higher in rainfall-treated russet and semi-russet fruit than in control fruit Pyrus × bretschneideri
altered fatty acid (FA) biosynthesis is involved in rainfall-induced russeting in sand pear fruit Pyrus × bretschneideri
VfHB21 overexpression causes downregulation of (AtLSM5, AtSAD1, LSM5, SAD1, AT5G48870) Arabidopsis thaliana
non-productive, competing pathways possibly down-regulated in seeds of host oilseeds seeds of host oilseeds
fatty acid structures in plant seed oils has guided discovery of novel biosynthetic enzymes
DEGs involved in fatty acid biosynthesis were expressed at very low levels prior to oil onset and then sharply upregulated in early days of rapid oil accumulation period oil accumulation onset
fatty acid metabolic pathways requires in-depth understanding in seeds that naturally accumulate high levels of unusual fatty acids solving bottlenecks that limit synthesis and accumulation of unusual fatty acids
cryoelectron microscopy is emerging technique that can be applied to fatty acid elongase complex and putative acyltransferase metabolons
NMR and protein–protein docking simulations used to characterize interactions present during E. coli fatty acid biosynthesis Escherichia coli
light-upregulated DEGs showed enrichment of carbon metabolism, biosynthesis of amino acid, fatty acid metabolism, and fatty acid biosynthesis pathway genes
three genes identified by Xu et al. (2019) were duplicated and predicted to be important in regulating VLCFA biosynthesis pathway in Moringa oleifera Moringa oleifera
fatty acid (FA) synthesis pathway is inhibited with up to 30 downregulated differentially expressed genes (DEGs) Arabidopsis thaliana
removal of (CTI1, AT1G42960) leads to enhanced de novo fatty acid biosynthesis Arabidopsis thaliana
transcription factors that up regulate fatty acid synthesis engineering of fatty acid synthesis
novel biosynthetic enzymes have provided insights into how structural variations can lead to alternative catalytic outcomes
α-ESA in developing seed cotyledons makes up approximately 50% of fatty acid components
reduced (CTI1, AT1G42960) level in the envelope membrane should result in enhanced de novo fatty acid biosynthetic flux Arabidopsis thaliana
enhanced de novo fatty acid biosynthesis rate is likely caused by (CTI1, AT1G42960) and cti123 mutants Arabidopsis thaliana
dense shade causes repression of genes involved in de novo FA biosynthesis Vernicia fordii
oleic acid remained largely equal between rich light and canopy light samples
engineered seeds of crop and model plant species produce long-chain omega-3 polyunsaturated fatty acids
FADX catalyzes conjugation of linoleic acid to produce α-ESA
linoleic acid produced by (AtFAD2, FAD2, AT3G12120) serves as substrate for FADX
very long-chain fatty acid (VLCFA) production bypasses PC-linked biosynthetic pathways
soybeans carrying mutations in GmSACPD-A, GmSACPD-B, and GmSACPD-D genes are potential new sources of high seed stearic acid while retaining good seed yield Glycine max
Acer truncatum produces seeds with high levels of valuable fatty acids Acer truncatum
fatty acid biosynthesis-related genes were systematically identified in Brassica napus Brassica napus
phosphatidylcholine is site of synthesis of novel fatty acids
(NTRC, AT2G41680) /2-Cys PRX redox system is important for lipid metabolism Arabidopsis thaliana
de novo fatty acid biosynthesis requires acetyl-CoA
acetate would have to be imported into chloroplast
thylakoid membranes harbor biochemical pathways for the synthesis of fatty acids (FAs)
GmLEC1c and GmLEC1d were unlikely to be involved in regulation of seed fatty acid biosynthesis Glycine max
GmLEC1a and GmLEC1b are involved in regulation of seed fatty acid biosynthesis Glycine max
lack of strong phenotypes of plastidial enolase and phosphoglycerate mutase mutants led to the suggestion that in oilseed embryos, all the 3-PGA generated in the plastid may be exported to the cytosol Arabidopsis thaliana
(AtSRT2, SRT2, AT5G09230) mutant shows variation in total fatty acid content Arabidopsis thaliana
epigenetic modulator (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) positively regulates expression of (AtFAD3, FAD3, AT2G29980) (LACS2, LRD2, AT1G49430) (ATLPP3, LPP3, AT3G02600) and PLAIII β Arabidopsis thaliana
(AAE13, AT3G16170) gene encodes mtAAE13 protein Arabidopsis thaliana
(FUS3, AT3G26790) overexpression increases expression of lower proportion of genes involved in fatty acid biosynthesis Arabidopsis thaliana
(AtFAP1, FAP1, AT3G63170) is found in module 2 Elaeis guineensis
palmitic acid is significantly higher in cultured pennycress embryos
histone acetyltransferase general control non-repressed protein 5 (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) modulates fatty acid biosynthesis Arabidopsis thaliana
(ATX2, SDG30, AT1G05830) mutant has total fatty acid content significantly reduced compared with wild-type plants Arabidopsis thaliana
lipid phosphate phosphatase 3 (ATLPP3, LPP3, AT3G02600) is downregulated gene in (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) mutant involved in fatty acid synthesis Arabidopsis thaliana
disruption of (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) results in moderately increased linoleic acid (LA, C18:2) content Arabidopsis thaliana
acetyl-CoA carboxylase catalyzes irreversible formation of malonyl CoA Chlorella UTEX29
inhibition of the glyoxylate cycle leads to increased availability of acetyl-CoA for fatty acid synthesis Chlamydomonas
ctAAE13 protein is not capable of complementing loss of (AAE13, AT3G16170) gene function Arabidopsis thaliana
ketoacyl-ACP synthase III (KASIII) is absent from Module 1 Elaeis guineensis
SAD-1 might correspond to main SAD isoform for 18:1 production Elaeis guineensis
two novel TFs identified in the FAS subnetwork play important role in FA biosynthesis
combining different alleles carrying Gmsacpd-a, Gmsacpd-b, Gmsacpd-d, and/or soft Gmsacpd-c (group II) mutations may have additive effect resulting in dramatic increase of stearic acid content Glycine max
35S:TPT lines had significantly increased total fatty acid content in seeds Arabidopsis thaliana
another alternative pathway for fatty acid biosynthesis should be considered in seeds Arabidopsis thaliana
fatty acid biosynthesis genes include one member of plant SACPD family proteins (GmSACPD-C) Glycine max
GmSACPD-C enzyme has been over-explored for use in producing high-stearic-acid soybeans Glycine max
mutations in GmSACPD-C play important role in nodule and leaf stearic acid content Glycine max
oleate desaturase (AtFAD2, FAD2, AT3G12120) gene modifications in biosynthesis of epoxy fatty acids
three alleles of CsFAD3 may explain higher levels of 18:3 (~35% versus ~20%) than found in diploid Arabidopsis Camelina sativa; Arabidopsis thaliana
potential dual sites for fatty acid biosynthesis can be proposed based on identification of PKS/FAS type I Chlorella vulgaris
DE genes were over-represented among genes related to fatty acid biosynthetic process, abiotic stress response, photosynthesis, integral components of membrane, and cell wall Zea mays
alternative pathways to provide precursors for fatty acid biosynthesis could exist fatty acid biosynthesis Arabidopsis thaliana
characterizations of effects of exogenous or engineered enzymes on fatty acid biosynthesis intermediates via mass spectrometry
high-stearic-acid lines will positively impact development of soybean nutritional value enhancement
Arabidopsis (ROD1, AT3G15820) mutant defective in phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT)-mediated flux displayed reduced hydroxy fatty acid synthesis in seeds engineered for castor bean hydroxylase expression Arabidopsis thaliana
GmWRI1a expression level is significantly correlated to seed oil content in mature seeds Glycine max
acetyl-CoA origin in chloroplast is still under debate
histone acetyltransferase general control non-repressed protein 5 (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) targets (LACS2, LRD2, AT1G49430) Arabidopsis thaliana
(BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) mutant has altered ratio of α-linolenic acid (ALA) to linoleic acid (LA) Arabidopsis thaliana
(ASHH3, SDG7, AT2G44150) mutant shows variation in total fatty acid content Arabidopsis thaliana
increased abundance in acetyl-CoA carboxylase (ACCase) and other fatty acid biosynthesis-related proteins upon long-term nitrogen starvation (−N) was observed in Chlorella vulgaris Chlorella vulgaris
metabolic flux study in nitrogen-starved heterotrophic Chlorella protothecoides suggests increased flux of carbon towards the synthesis of fatty acids upon nitrogen starvation (−N) Chlorella protothecoides
mitochondria require malonyl-CoA to support biosynthesis of fatty acids
plastidial and mitochondrial systems is Type II FAS systems
Module 1 contains genes involved in core fatty acid biosynthetic machinery Elaeis guineensis
(AtFaTA, FaTA, FATA1, AT3G25110) FATB1, FATB2, KASII, SAD-1, SAD-2 are genes likely to control fatty acid composition of mesocarp oil Elaeis guineensis
evolution of variations in enzymatic and nonenzymatic protein structures, stoichiometry, and protein–protein interactions can give rise to extremes in fatty acid chain lengths—short and long—as well as unique functional groups
successive condensation reactions catalysed by KAS, KAR, HD, and ENR yield C16:0- and C18:0-ACP Haematococcus pluvialis
(AtSRT2, SRT2, AT5G09230) mutant has total fatty acid content significantly reduced compared with wild-type plants Arabidopsis thaliana
(AtFAD3, FAD3, AT2G29980) has crucial role in ALA synthesis Arabidopsis thaliana
constitutive expression of (AtFAD3, FAD3, AT2G29980) in (BGT, GCN5, HAC3, HAG01, HAG1, HAT1, AT3G54610) mutant seeds significantly increases ALA content Arabidopsis thaliana
acetyl-CoA is substrate of plastidial fatty acid synthase (ptFAS) system
18:3 at the sn-2 position of TAG in ar21 showed major reduction Arabidopsis thaliana
GO term 'fatty acid biosynthetic process' is significantly enriched in downregulated genes in spines of 1.6cm fruit Cucumis sativus
three different proteins of nuclear-encoded subunits of acetyl CoA carboxylase corresponding to four different genes ( (BCCP, BCCP-1, BCCP1, CAC1, CAC1-A, CAC1A, AT5G16390) (CAC2, AT5G35360) and (CAC3, AT2G38040) ) Solanum lycopersicum
significant up-regulation of acetyl-CoA carboxylase gene (ACCD, ATCG00500) reported in chromoplasts Solanum lycopersicum
overexpression of acyl-ACP Δ9-desaturase gene does not significantly change total fatty acid accumulation Phaeodactylum tricornutum
microalgal fatty acid synthetic process in the chloroplast is shown in Figure 8 Haematococcus pluvialis
dense shade inhibits total oil and α-ESA biosynthesis
(AtFAD2, FAD2, AT3G12120) desaturase catalyzes desaturation of oleic acid to produce linoleic acid
(AtFAD2, FAD2, AT3G12120) RNAi transgene increases oleic acid content Crambe abyssinica
reassimilation of CO2 generated from OxPPP by Rubisco clearly shown in non-photosynthetic oil-accumulating seeds
stearoyl-ACP desaturase is responsible enzyme for oleate production Olea europaea
significant decrease in several saturated fatty acids during the 2-h dark period could be expected since fatty acid biosynthesis is known to be stimulated in the light Arabidopsis thaliana
overexpression of CsaLPAT2 significantly increased C20:0 content Arabidopsis thaliana
Fatty acid biosynthetic process (GO:0006633) is enriched for GPAT5-associated translatome Arabidopsis thaliana
heteromeric acetyl-CoA carboxylase (ACCase) functions in de-novo biosynthesis of fatty acids
lipid biosynthesis capacity in tomato chromoplast is attested by presence of all proteins involved in synthesis of 3-oxoacyl-ACP Solanum lycopersicum
plastid-encoded (ACCD, ATCG00500) found in tomato chromoplast proteome Solanum lycopersicum
(ACCD, ATCG00500) is only plastid-encoded gene involved in fatty acid biosynthesis showing stable expression in chromoplasts Solanum lycopersicum
CM102G09, CM006G10, and CM032E11 are important for fatty acid biosynthesis Gossypium hirsutum
metabolic changes are a direct consequence of missing mtAAE13 function Arabidopsis thaliana