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dna damage response

17779 relationships annotated with this phrase. Showing first 500 of 17779.
Source entity Relationship Target entity Species
ddrm2 mutants are not sensitive to HU-induced replication stress
SA can trigger DNA damage Arabidopsis thaliana
(ANAC008, SOG1, AT1G25580) (Suppressor of Gamma Response1) associates with DDRM2 promoter Arabidopsis thaliana
DDRM2 may be functional counterpart of MDC1
linear model best describes interaction between number of (ATRAD51, RAD51, AT5G20850) mRNAs and extent of DNA damage Arabidopsis thaliana
G2/M reporter expression increases with increasing concentrations of zeocin Arabidopsis thaliana
chronic exposure to As(III) can lead to increased DNA damage
CIP treatment effect is most likely due to DSB-inducing activity
DDRM2 functions downstream of (ANAC008, SOG1, AT1G25580) Arabidopsis thaliana
(ATRAD51, RAD51, AT5G20850) transcriptional output exhibits decrease in elongation zone compared with meristem region Arabidopsis thaliana
(ATWHY1, PTAC1, WHY1, AT1G14410) and (ATWHY3, PTAC11, WHY3, AT2G02740) mutants are sensitive to ciprofloxacin (CIP) Arabidopsis thaliana
ddrm2-1 mutant shows hypersensitivity to camptothecin (CPT) Arabidopsis thaliana
DNA damage can lead to programmed cell death (PCD) Arabidopsis thaliana
(AT4G02110) gene encodes protein with four (ATBRCA1, BRCA1, AT4G21070) C-terminal (BRCT) domains Arabidopsis thaliana
(ANAC008, SOG1, AT1G25580) (Suppressor of Gamma Response1) activates DDRM2 expression Arabidopsis thaliana
phosphorylated H2AX forms foci DNA damage foci
DNA damage response reveals new associations with cell cycle Arabidopsis thaliana
phosphorylated H2A.X histone variant (γH2AX) participates in early signaling of DNA lesion
DDRM2 functions downstream of (ANAC008, SOG1, AT1G25580) (Suppressor of Gamma Response1) Arabidopsis thaliana
zeocin promotes arrest at G1/S checkpoint
induced expression of DDRM2 is abolished in sog1-1 mutant Arabidopsis thaliana
PTIP contains BRCT domain
(ATRAD51, RAD51, AT5G20850) transcription is dose-dependent Arabidopsis thaliana
(ATRAD51, RAD51, AT5G20850) transcription occurs outside S/G2 cell cycle phases
(ATRAD51, RAD51, AT5G20850) shows transcriptional response to DNA damage Arabidopsis thaliana
stem cell death likely explains highest (ATRAD51, RAD51, AT5G20850) mRNA levels in stem cells following 10 μM zeocin treatment Arabidopsis thaliana
higher (ATRAD51, RAD51, AT5G20850) transcript output in stele cells is possibly explained by abundance of EdU-positive cells in stele Arabidopsis thaliana
E. coli ITPA mutant has induced SOS response Escherichia coli
BRCT domain is present in many DNA damage response (DDR) proteins
DDRM2 may have functions other than homologous recombination (HR)
H2AXA-YFP and DDRM2-mCherry foci partially overlap DNA damage sites
histone γH2AX levels correlate with DNA damage amounts
ddrm2-2 (ATRAD51, RAD51, AT5G20850) double mutant is more sensitive to camptothecin (CPT) Arabidopsis thaliana
greater accumulation of damage may underscore elevated transcriptional response of (ATRAD51, RAD51, AT5G20850) in stele cells
(ANAC008, SOG1, AT1G25580) plays crucial role in transcriptional regulation of DDR genes
DSBs induce expression of DDRM2 Arabidopsis thaliana
DNA damage response (DDR) activation leads to cell cycle arrest
increasing zeocin concentration causes drastic decline in number of EdU-positive cells Arabidopsis thaliana
root stele cells differ from other cell types in cell cycle changes
root stele cells exhibit more extensive (ATRAD51, RAD51, AT5G20850) transcriptional activation
(ANAC008, SOG1, AT1G25580) induces expression of DDRM2
different sources of DNA damage induce different types of lesions
DDRM2 expression is induced upon DNA damage treatment Arabidopsis thaliana
ddrm2-2 (ATRAD51, RAD51, AT5G20850) double mutant is more sensitive to CPT than (ATRAD51, RAD51, AT5G20850) single mutant
zeocin treatment increases (ATRAD51, RAD51, AT5G20850) mRNA levels Arabidopsis thaliana
SUPPRESSOR OF GAMMA RESPONSE1 (ANAC008, SOG1, AT1G25580) is functional counterpart of p53
DNA damage induces DNA damage response (DDR) Arabidopsis thaliana
Arabidopsis thaliana roots is model system for investigating DNA damage response Arabidopsis thaliana
(ATRAD51, RAD51, AT5G20850) transcription shows positive correlation with increasing amounts of damage
repair of double-strand breaks (DSBs) is critical for cell survival
DDRM2 is homolog of human HsTOPBP1
CRISPR-Kill system relies on double-strand break (DSB) induction
cell cycle arrest provides necessary time for repair
stem cells show highest RAD51 mRNA levels following 10 μM zeocin treatment Arabidopsis thaliana
DNA damaging agent induces varying (ATRAD51, RAD51, AT5G20850) mRNA transcriptional output
DNA damage may directly impact expression of reporter genes
G2/M-marker gene (CYC1, CYCB1, CYCB1;1, AT4G37490) is responsive to DNA damage
genomic repeated genomic DNA is susceptible to damage DNA damage Neurospora crassa
double-stranded breaks (DSBs) triggers DNA damage response (DDR) activation
differences in (ATRAD51, RAD51, AT5G20850) promoter activity may explain varying (ATRAD51, RAD51, AT5G20850) mRNA transcriptional output
camptothecin (CPT) causes double-strand breaks (DSBs) Arabidopsis thaliana
phosphorylation of H2AX is one of the earliest events following formation of double-strand breaks (DSBs)
(ATRAD51, RAD51, AT5G20850) can be transcribed in G1 phase
DSBs induces expression of DDRM2 Arabidopsis thaliana
double-strand breaks (DSBs) activate (ANAC008, SOG1, AT1G25580)
DNA damage response in plants demonstrates quantitative differences in DDR activation Arabidopsis thaliana
ddrm2-2 (ATRAD51, RAD51, AT5G20850) double mutant is more sensitive to CPT than ddrm2-2 single mutant
Arabidopsis thaliana encodes (G-H2AX, GAMMA-H2AX, H2AXA, HTA5, AT1G08880) and (G-H2AX, GAMMA-H2AX, H2AXB, HTA3, AT1G54690) Arabidopsis thaliana
G1/S and G2/M checkpoints can be used to ensure cell cycle arrest in response to DNA damage
genome is constantly challenged by genotoxic insults
histone γH2AX dynamics of recruitment and loss are employed to measure DSB repair dynamics
MDC1 contains BRCT domain
number of (ATRAD51, RAD51, AT5G20850) mRNA molecules detected per cell increases in response to increasing zeocin concentrations Arabidopsis thaliana
DDRM2 expression is dependent on (ANAC008, SOG1, AT1G25580) (Suppressor of Gamma Response1) Arabidopsis thaliana
zeocin concentration and cell type parameters show significant interaction in (ATRAD51, RAD51, AT5G20850) transcriptional response Arabidopsis thaliana
putative orthologs of 22 genes induced by genotoxic agents were analyzed for expression patterns in EBC Mesembryanthemum crystallinum
gh1-hmga1-2 mutants are hypersensitive to mitomycin C (MMC) Arabidopsis thaliana
ddrm2 mutant is hypersensitive to DSB-inducing reagents Arabidopsis thaliana
phosphorylated H2A.X histone variant (γH2AX) participates in recruitment of DNA repair machinery proteins
cells modulate (ATRAD51, RAD51, AT5G20850) transcription
hydroxyurea (HU) treatment activates G1/S checkpoint
down-regulation of (HMGA, AT1G14900) proteins enhances cancer cell sensitivity to DNA damage
cells undergo arrest at G2/M checkpoint
absence of GH1-HMGA1 would result in higher amounts of histone H1 on DNA at double-strand break (DSB) sites Arabidopsis thaliana
absence of histone H1 promotes homologous recombination (HR) Saccharomyces cerevisiae
genotoxic stress causes severe damage to nucleic acids
two genes in DNA damage response set were significantly down-regulated Mesembryanthemum crystallinum
(HMGA, AT1G14900) proteins have role in DNA damage response (DDR) process
(PARP1, AT2G31320) and (APP, PARP2, PP, AT4G02390) genes are up-regulated by DNA damage
seedlings of wild-type, main-2 and pp7l-1 were incubated for 2 h with DNA damaging drug zeocin Arabidopsis thaliana
transgenic plants harboring iMseI expression vector subjected to incubation at elevated temperatures show elevated expression of DSB-responsive genes ( (ATBRCA1, BRCA1, AT4G21070) and (ATRAD51, RAD51, AT5G20850) ) Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) mutant shows MMS sensitivity Arabidopsis thaliana
WT or m123-2 genotypes show relatively mild effect of acute (ACPT, AtcPT3, CPT, cPT3, AT2G23410) treatment Arabidopsis thaliana
plateau of (PARP1, AT2G31320) and (ATBRCA1, BRCA1, AT4G21070) expression is lower in (FAS1, FUGU2, NFB2, AT1G65470) m123-2 than Arabidopsis thaliana
DNA-damage response (DDR) results in chromosome fusions
limiting amount of histone H1 on DNA at double-strand break (DSB) sites favors homologous recombination (HR) repair Arabidopsis thaliana
gh1-hmga1-2 mutants show less than 20% of plants showing resistance to γ-irradiation Arabidopsis thaliana
higher order chromatin organization imposed by histone H1 inhibits homologous recombination (HR)
DNA repair function of GH1-HMGA1 seems to be widely conserved in eukaryotes
Arabidopsis (CST, CX32, Kin4, PBL30, AT4G35600) subunit ( (ATCTC1, CTC1, AT4G09680) (ATSTN1, STN1, AT1G07130) or (MDO1, TEN1, AT1G56260) ) mutation is accompanied by massive genomic instability Arabidopsis thaliana
Arabidopsis (GRL, LPL3, NAP1, NAPP, AT2G35110) is important for somatic homologous recombination (HR) Arabidopsis thaliana
cell death in (PP7L, AT5G10900) mutants was caused by constitutive activation of (ANAC008, SOG1, AT1G25580) Arabidopsis thaliana
SOG1-independent cell death was suggested to be consequence of DNA repair processes not being efficiently activated Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) m123-2 mutant shows ratio more similar to m123-2 mutant than (FAS1, FUGU2, NFB2, AT1G65470) or WT Arabidopsis thaliana
mammalian (HMGA, AT1G14900) overexpression sensitizes cancer cell lines to cisplatin Homo sapiens
DSBs-induced expression of DDRM2 is SOG1-dependent manner Arabidopsis thaliana
(ATXRCC1, XRCC1, AT1G80420) contains BRCT domain
increasing zeocin concentrations increases total number of (ATRAD51, RAD51, AT5G20850) transcripts in root meristem Arabidopsis thaliana
absence of histone H1 correlates with greater ability to repair double-strand breaks (DSB) Saccharomyces cerevisiae; Mus musculus
release of (POL, AT2G46920) II and its nascent transcript from the 3′end of highly transcribed genes enhances genome stability Saccharomyces cerevisiae
(FAS1, FUGU2, NFB2, AT1G65470) (GRL, LPL3, NAP1, NAPP, AT2G35110) ;1 ;2 ;3 quadruple mutant shows decreased sensitivity to genotoxic stress Arabidopsis thaliana
(GRL, LPL3, NAP1, NAPP, AT2G35110) is not required to activate H2A.X phosphorylation via (ATATM, ATM, ATM-1, PIG1, AT3G48190) or (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) in (FAS1, FUGU2, NFB2, AT1G65470) Arabidopsis thaliana
loss of function of MAIN and its interaction partners (MAIL1, AT2G25010) and (PP7L, AT5G10900) leads to genome instability
(FAS1, FUGU2, NFB2, AT1G65470) mutant shows equal sensitivity to MMS, MMC and bleomycin Arabidopsis thaliana
(PARP1, AT2G31320) binds damaged DNA
(ABO4, EMB142, EMB2284, EMB529, ESD7, POL2A, TIL1, AT1G08260) mutants did not accumulate more DSBs than wild type
(POLQ, TEB, AT4G32700) gene genetically interacts with (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) Arabidopsis thaliana
DDR signalling was not impaired in main-2 and pp7l-1 mutants Arabidopsis thaliana
typical symptoms of active DNA damage response includes precocious cell differentiation in RAM
DNA damage detection leads to activation of (ATATM, ATM, ATM-1, PIG1, AT3G48190) AND RAD3-RELATED (ATATR, ATR, ATR-2, ATRAD3, AT5G40820)
(FAS1, FUGU2, NFB2, AT1G65470) genotype shows overall highest level of damage Arabidopsis thaliana
incorrect chromatin assembly in (FAS1, FUGU2, NFB2, AT1G65470) is related to increased sensitivity to genotoxic stress Arabidopsis thaliana
six-base cutters do not significantly elevate (ATBRCA1, BRCA1, AT4G21070) expression Arabidopsis thaliana
disruption of (GRL, LPL3, NAP1, NAPP, AT2G35110) genes in (FAS1, FUGU2, NFB2, AT1G65470) causes general tolerance to genotoxic stress Arabidopsis thaliana
conserved pathways are activated in a similar way in (FAS1, FUGU2, NFB2, AT1G65470) and m123-2 Arabidopsis thaliana
severe DNA damage leads to expression of DNA replication-related and DNA repair-related genes Oryza sativa
loss of function of MAIN/ (MAIL1, AT2G25010) (PP7L, AT5G10900) complex was associated with genome instability Arabidopsis thaliana
DNA damage response (DDR) activation results in transient arrest of root growth Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) m123-2 mutant shows about half of (ATBRCA1, BRCA1, AT4G21070) and (PARP1, AT2G31320) expression in (FAS1, FUGU2, NFB2, AT1G65470) Arabidopsis thaliana
PARP family members in humans are activated and recruited in response to single-strand and double-strand DNA breaks Homo sapiens
DNA damage accumulates in seeds even in the absence of external stresses
OsPARP1 is upregulated by bleomycin Oryza sativa
chloroplast-targeted RecA mRNA increases in response to DNA damage Physcomitrella patens
SOG1-independent cell death supported conclusion that cell death was caused by genome instability Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) genotype shows all roots examined with small or large lesions Arabidopsis thaliana
treatment with DNA damaging agents (zeocin or bleomycin) or ionizing radiation leads to activation of DNA damage response (DDR) Arabidopsis thaliana
activation of programmed cell death (PCD) in root initials is an important response to DNA damage Arabidopsis thaliana
typical symptoms of active DNA damage response includes reduced cell division
DSB-responsive genes upregulated in a heat-dependent manner in tetraploid plants Arabidopsis thaliana
(ATATM, ATM, ATM-1, PIG1, AT3G48190) AND RAD3-RELATED (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) phosphorylates SUPPRESSOR OF GAMMA-RESPONSE 1 (ANAC008, SOG1, AT1G25580)
loss of function of MAIN and its interaction partners (MAIL1, AT2G25010) and (PP7L, AT5G10900) leads to constitutive DNA damage
MseI restriction enzyme induces highest (ATBRCA1, BRCA1, AT4G21070) expression Arabidopsis thaliana
(ANAC008, SOG1, AT1G25580) is activated upon DNA damage
bleomycin treatment activated OsPARP1 expression Oryza sativa
all tested genes was induced in (POLQ, TEB, AT4G32700) single mutants and (ABO4, EMB142, EMB2284, EMB529, ESD7, POL2A, TIL1, AT1G08260) compared to wild type
Chaos1 mouse mutants are viable but show genomic instability, especially in erythrocytes Mus musculus
DNA damage triggers via the activity of (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) and STEMINs Physcomitrella patens
main-2 sog1-7 double mutant showed more cell death than main-2 single mutant
(GRL, LPL3, NAP1, NAPP, AT2G35110) genes or act as key mediators of DNA damage response in (FAS1, FUGU2, NFB2, AT1G65470) Arabidopsis thaliana
repair of protein–DNA crosslinks occurs via dedicated enzyme complexes
constitutive activation of DDR is consistent with role of (POL, AT2G46920) θ in maintenance of genome integrity Arabidopsis thaliana
replicative stress induced by (POL, AT2G46920) ε deficiency is enhanced by lack of (POL, AT2G46920) θ
cells overexpressing HMGA2 have prolonged presence of DNA-PKcs at DSB sites
(FAS1, FUGU2, NFB2, AT1G65470) mutant shows four-fold higher (PARP1, AT2G31320) than WT Arabidopsis thaliana
successful DNA repair allows cell survival
cell-type-specific programmed cell death (PCD) is seen after 20-h treatment with radiometric drug zeocin Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) m123-2 genotype shows stronger response to acute (ACPT, AtcPT3, CPT, cPT3, AT2G23410) treatment Arabidopsis thaliana
WT genotype indicates relatively mild effect of chronic (ACPT, AtcPT3, CPT, cPT3, AT2G23410) treatment Arabidopsis thaliana
all tested DDR marker genes were significantly induced in (POLQ, TEB, AT4G32700) mutants grown in the presence of salt compared to control conditions
DNA damage signalling is little known in plants
poly [ADP-ribose] polymerase 1 (PARP-1) plays critical role in genomic stability by mediating DNA damage surveillance network
ETHYLEN RESPONSE FACTOR 115 (ERF115, AT5G07310) showed significantly increased expression in pp7l-1 and pp7l-3 mutant lines compared with wild-type Arabidopsis thaliana
increased expression of DDR-related genes was previously shown to occur in root tips of main-2 and mail1-1 seedlings Arabidopsis thaliana
riboflavin deficiency caused DNA damage Oryza sativa
severe DNA damage may induce permanent cell proliferation arrest
transcription factors (anac044, NAC044, AT3G01600) and (anac085, NAC085, AT5G14490) are activated by DNA damage Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) m123-2 shows lower levels of (ATBRCA1, BRCA1, AT4G21070) and (PARP1, AT2G31320) transcripts Arabidopsis thaliana
PARPs play critical roles in regulating DNA damage
impaired repair of replication-associated DNA damage could lead to activation of the DDR
mutations in Drosophila gene MUS308 induce hypersensitivity to replication-blocking lesions such as inter-strand cross-links Drosophila melanogaster
(ATATM, ATM, ATM-1, PIG1, AT3G48190) mutant meiocytes have increased DSB numbers
atbrca2a-1 / atbrca2b-1 double mutant shows additive increase in sensitivity to genotoxic stresses Arabidopsis thaliana
AtBRCA2a-1 –/– / AtBRCA2a-1 +/– heterozygous plants shows sensitivity to cisplatin same as atbrca2a single mutant plants Arabidopsis thaliana
expression levels of XRI-1, BRCA2, and (SMR7, AT3G27630) were increased approximately 1.7-fold by salt treatment in wild type
chilling, heavy metal, or oxidative stresses can cause DNA strand breaks
SUPPRESSOR OF GAMMA-RESPONSE 1 (ANAC008, SOG1, AT1G25580) induces transcriptional induction of cell cycle inhibitors
(ANAC008, SOG1, AT1G25580) induces cell-type-specific programmed cell death in root initials
(FAS1, FUGU2, NFB2, AT1G65470) mutant shows no further induction of (ATBRCA1, BRCA1, AT4G21070) expression after (ACPT, AtcPT3, CPT, cPT3, AT2G23410) treatment Arabidopsis thaliana
repair of protein–DNA crosslinks occurs via conserved repair machineries, such as the (ATMRE11, MRE11, AT5G54260) (ATRAD50, RAD50, AT2G31970) /NBSI complex and (ATBRCA1, BRCA1, AT4G21070)
these genes displayed even higher upregulation in (ABO4, EMB142, EMB2284, EMB529, ESD7, POL2A, TIL1, AT1G08260) (POLQ, TEB, AT4G32700) than in single mutants
atbrca2a-1 single mutant is hypersensitive to cisplatin Arabidopsis thaliana
Deficiency in non-replicative polymerases results in hypersensitivity to various DNA-damaging agents
DNA single-strand breaks (SSBs) trigger complex cascade of events involving (PARP1, AT2G31320)
reactive carbonyls form genotoxic DNA–protein cross-links Arabidopsis thaliana
energy-rich radiation exerts chromatin changes
repair of DNA strand breaks requires (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) kinase Physcomitrella patens
programmed cell death (PCD) in root initials prevents accumulation and propagation of deleterious mutations
homologous recombination-mediated DNA repair pathway might not be activated in pp7l-1 and pp7l-3 mutant lines Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) m123-2 mutant shows higher proportion of PI-stained roots than WT Arabidopsis thaliana
(ATATM, ATM, ATM-1, PIG1, AT3G48190) kinase deletion in (FAS1, FUGU2, NFB2, AT1G65470) mutant causes expression of (ATBRCA1, BRCA1, AT4G21070) and (PARP1, AT2G31320) returns to wild-type levels Arabidopsis thaliana
low UV-C doses produced limited amounts of topo I covalent complexes (TCCs) Homo sapiens
large-scale decondensation of the chromatin could promote DNA damage as a response to substances occurring in enzyme solution for cell wall degradation
DNA lesions are recognized and trigger DNA damage response (DDR)
(ABO4, EMB142, EMB2284, EMB529, ESD7, POL2A, TIL1, AT1G08260) (POLQ, TEB, AT4G32700) double mutants accumulated significantly higher levels of γ-H2AX foci
consequences of salinity on DNA have been less explored
DDR gene activation did not differ significantly between small and big (POLQ, TEB, AT4G32700) mutants
loss of (POL, AT2G46920) θ results in increase in DNA damage accumulation in proliferating cells
consequences of drought on DNA have been less explored
DNA damage occurs in cell nuclei
topoisomerase I (topo I) shows temporal accumulation at damaged sites
(FAS1, FUGU2, NFB2, AT1G65470) mutant shows increased sensitivity to MMS Arabidopsis thaliana
constitutive activation of DNA repair occurs in both (FAS1, FUGU2, NFB2, AT1G65470) and m123-2 mutants Arabidopsis thaliana
DNA double-strand breaks trigger complex cascade of events involving (PARP1, AT2G31320)
DNA lesions activate ATAXIA TELANGIECTASIA MUTATED (ATATM, ATM, ATM-1, PIG1, AT3G48190) target genes Arabidopsis thaliana
WT genotype shows 50% of roots remaining intact after 6 days of (ACPT, AtcPT3, CPT, cPT3, AT2G23410) treatment Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) and (FAS2, MUB3.9, NFB01, NFB1, AT5G64630) mutants show increased expression levels of (ATRAD51, RAD51, AT5G20850) Arabidopsis thaliana
(ATBRCA1, BRCA1, AT4G21070) and (PARP1, AT2G31320) expression in (FAS1, FUGU2, NFB2, AT1G65470) m123-2 is higher than in wild-type Arabidopsis thaliana
consequences of light intensity on DNA have been less explored
chloroplast-targeted RecA mRNA increases in response to DNA damage pea
chloroplast chromosomes transmitted to next generation might sustain less damage than cpDNA in green cells Arabidopsis thaliana
mutants of genes associated with DNA metabolism are sensitive to DNA mutagens
UV-light is efficient inducer of formation of topo I-DNA complexes
fragmentation of cpDNA molecules in cprecA mutants increased only slightly after treatment with ciprofloxacin Arabidopsis thaliana
ectopically expressed marker (APP, PARP2, PP, AT4G02390) is not supported by present transcriptome analysis of (ATTOP6B, BIN3, HLQ, HYP6, RHL3, TOP6B, AT3G20780) Arabidopsis thaliana
GSTs and superoxide dismutase protect DNA against radiation
(MOM, MOM1, AT1G08060) mutants do not show hypersensitivity to DNA damage agent MMS Arabidopsis thaliana
response of (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) loss-of-function mutants to Al is opposite to response of (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) loss-of-function mutants to hydroxurea or ionizing radiation Arabidopsis thaliana
molecular integrity of branched cpDNA was greatly reduced in wt plants treated with ciprofloxacin Arabidopsis thaliana
hydrogen peroxide is efficient inducer of formation of topo I-DNA complexes
(POL, AT2G46920) θ deficiency results in dramatic increase of tumorigenesis upon UV exposure Homo sapiens
chloroplast-targeted RecA mRNA increases in response to DNA damage Chlamydomonas reinhardtii
chloroplast-targeted RecA mRNA increases in response to DNA damage Arabidopsis thaliana
γ-irradiation (600 Gy) accelerates stem fasciation phenotype Arabidopsis thaliana
AtCYCB1;1 induction in response to cisplatin in atbrca2a-1/atbrca2b-1 double mutant is compared to AtCYCB1;1 induction in wild-type plants Arabidopsis thaliana
Ataxia telangiectasia mutated related (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) -related pathway could actively slow root growth
OsPARP1 respond to DNA damage Oryza sativa
PARP, (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) (ATRAD51C, RAD51C, AT2G45280) and RAD51A2 have upregulated transcript levels in (ELL1, FK, HYD2, AT3G52940) plants Oryza sativa
staurosporine is efficient inducer of formation of topo I-DNA complexes
homozygous BRCA2 mutant mice show chromosomal rearrangements and breaks Mus musculus
rpa2-4 mutant is extremely sensitive to methyl methanesulfonate (MMS) Arabidopsis thaliana
(ATATM, ATM, ATM-1, PIG1, AT3G48190) kinase is the major kinase that phosphorylates (h2a.w.7, HTA7, AT5G27670) and H2A.X Arabidopsis thaliana
(h2a.w.7, HTA7, AT5G27670) performs unique function in heterochromatin-associated DNA damage response (DDR) Arabidopsis thaliana
ATM-dependent phosphorylation of HP1 and KAP1 facilitates double-strand break (DSB) repair mammals
γ-irradiation increases ratio of plants displaying fasciation and abnormal phyllotaxy phenotypes Arabidopsis thaliana
cells respond to DNA lesions by activation of intricate web of signalling pathways
Nossen ecotype is one of ecotypes with relatively higher sensitivity to γ-irradiation Arabidopsis thaliana
SQEF motif of Arabidopsis H2A.X is phosphorylated in response to DNA damage Arabidopsis thaliana
application of bleomycin may further induce DNA damage at M phase in CDKB2;1 knockdown callus
AtBRCA2 mutation enhances AtCYCB1;1 induction by cisplatin Arabidopsis thaliana
AtCYCB1;1 is strongly induced by DNA damaging agents Arabidopsis thaliana
extrinsic DSBs and inefficient repair of DSBs induce abnormal morphological phenotype Arabidopsis thaliana
disruption of TgPCNA2 gene did not influence response to chemical mutagens Toxoplasma gondii
atbrca2a-1 / atbrca2b-1 double mutant shows additive increase in sensitivity to genotoxic stresses Arabidopsis thaliana
transcription machinery may play important role in sensing DNA damage and activating DNA repair and stress response pathways Synechocystis sp. PCC 6803
ros1rpa2-1 mutant is extremely sensitive to methyl methanesulfonate (MMS) Arabidopsis thaliana
wild-type plants are tolerant to methyl methanesulfonate (MMS) Arabidopsis thaliana
genes presenting type III variability have likely functions that are diverse
(ANAC008, SOG1, AT1G25580) functions in DNA damage signalling response Arabidopsis thaliana
atbrca2b-1 single mutant is hypersensitive to γ-irradiation Arabidopsis thaliana
atbrca2a-1 / atbrca2b-1 double mutant shows additive increase in sensitivity to genotoxic stresses Arabidopsis thaliana
UV-C and γ-rays cause wide variety of DNA breaks and damage Arabidopsis thaliana
ros1rpa2-1 mutant shows no difference to UV stress Arabidopsis thaliana
(ATATR, ATR, ATR-2, ATRAD3, AT5G40820) encodes ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) Arabidopsis thaliana
plants may have evolved histone variants combining the properties of H2A.X and H2A.W plants
DNA double-strand breaks (DSBs) enhance endoreduplication Arabidopsis thaliana
plants use endoreduplication as bypass pathway to avoid cell-cycle arrest or cell death by DNA damage
G 2 arrest or inhibition of mitosis is not major DNA damage response in rice
(ANAC008, SOG1, AT1G25580) functions downstream of (ATATM, ATM, ATM-1, PIG1, AT3G48190) and (ATATR, ATR, ATR-2, ATRAD3, AT5G40820)
genetic screening for DNA damage response mutants (DDRMs) found ddrm2 mutant Arabidopsis thaliana
DNA damage activates (ATRAD51, RAD51, AT5G20850) transcription
G1 cells increase in amount with increasing concentrations of zeocin Arabidopsis thaliana
DDRM2-YFP forms foci in approximately 90% of cells when treated with bleomycin (BLM) Arabidopsis thaliana
number of (ATRAD51, RAD51, AT5G20850) mRNA molecules per cell shows positive correlation with γH2AX levels Arabidopsis thaliana
differences in DNA damage sensitivity may explain varying (ATRAD51, RAD51, AT5G20850) mRNA transcriptional output
TOPBP1 contains BRCT domain
double-stranded breaks (DSBs) requires immediate repair
DNA strand distortions caused by photodimers block transcription and replication
(ANAC008, SOG1, AT1G25580) (SUPPRESSOR OF GAMMA RESPONSE 1) appears to function in responses to UV-B-induced DNA damage Arabidopsis thaliana
ataxia telangiectasia mutated (ATATM, ATM, ATM-1, PIG1, AT3G48190) kinase phosphorylates H2A.X histone variant
function of cell cycle-related factors in the DNA damage response in plants is not clear in plants
double-strand breaks (DSBs) is most threatening type of DNA damage in living cells
DNA lesions are rapidly detected in cells
gamma irradiation induces (ATRAD54, CHR25, RAD54, AT3G19210) foci emergence Arabidopsis
BRCT domain of MDC1 is the major mediator for recognition of phosphorylated H2AX
cells with no EdU signal contain abundant number of (ATRAD51, RAD51, AT5G20850) mRNA molecules Arabidopsis thaliana
increase in G1 cells indicates potential cell cycle arrest at G1/S checkpoint Arabidopsis thaliana
upregulation of DDR genes is key element of DDR response
γH2AX foci in rfc1–2 mutant decrease slowly and more remain at pachytene stage Arabidopsis thaliana
plants do not display arrest in prophase I or apoptosis in response to unrepaired DSBs
γH2AX foci in rfc1–2 meiocytes were maintained at relatively high level Arabidopsis thaliana
anthers of ctf7-1 plants contained elevated transcript levels for (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) kinase Arabidopsis thaliana
TUNEL-positive signal in (MAIL1, AT2G25010) mutant root meristem may be direct consequence of unstable and damaged DNA or result from programmed cell death
(ATRAD51, RAD51, AT5G20850) transcription in response to DNA damage is coincident with cell cycle arrest at G2/M checkpoint Arabidopsis
(SMR5, AT1G07500) control cell cycle arrest in response to genotoxic stress Arabidopsis thaliana
DDRM2 is involved in both non-homologous end joining (NHEJ) and homologous recombination (HR) Arabidopsis thaliana
shorter cell cycle duration may explain elevated (ATRAD51, RAD51, AT5G20850) transcriptional response in stele cells
sog1-1 mutation reversed UV-B-hypersensitive phenotype of xpf Arabidopsis thaliana
genes involved in damage sensing ( (RBB1, AT5G40450) (CIPK3, SnRK3.17, AT2G26980) (AtCPK21, CPK21, AT4G04720) ) were upregulated by low CO2 Arabidopsis thaliana
(ANAC008, SOG1, AT1G25580) (SUPPRESSOR OF GAMMA RESPONSE 1) is responsible for expression of several genes induced after γ-irradiation Arabidopsis thaliana
histones, ubiquitin-related genes, and DNA-binding proteins are higher in BQC compared to good-quality cork (GQC) Quercus suber
(ATRPA2, ATRPA32A, ROR1, RPA2, RPA32A, AT2G24490) mutants are hypersensitive to methyl methanesulphonate Arabidopsis thaliana
two histone variants H2A.X and (h2a.w.7, HTA7, AT5G27670) function in parallel to protect genome integrity Arabidopsis thaliana
(ANAC008, SOG1, AT1G25580) (SUPPRESSOR OF GAMMA RESPONSE 1) has been shown to process signals associated with multiple responses to DNA damage
Arabidopsis thaliana mutants of the photolyases and NER enzymes are hypersensitive when irradiated with UV-B or UV-C Arabidopsis thaliana
SQEF motif of Arabidopsis H2A.X phosphorylation suggests conservation of H2A.X function in DNA damage response (DDR) Arabidopsis thaliana
bleomycin and zeocin treatment strongly induced transcription of DNA damage response genes (ATRAD51, RAD51, AT5G20850) (ATBRCA1, BRCA1, AT4G21070) and (CYC1, CYCB1, CYCB1;1, AT4G37490) Arabidopsis thaliana
H2A.X and (h2a.w.7, HTA7, AT5G27670) act in parallel in DNA damage response (DDR) Arabidopsis thaliana
(FAS1, FUGU2, NFB2, AT1G65470) mutants are hypersensitive to DNA damage agent MMS Arabidopsis thaliana
CDKB2 functions differently in response to DNA damage Arabidopsis thaliana; Oryza sativa
ectopically expressed marker (ATRAD51, RAD51, AT5G20850) is not supported by present transcriptome analysis of (ATTOP6B, BIN3, HLQ, HYP6, RHL3, TOP6B, AT3G20780) Arabidopsis thaliana
genotoxic agents (such as H2O2) treatment with causes DNA lesions in mitochondrial DNA (mtDNA)
mutations in C-terminal acetyltransferase domain of (AtCTF7, CTF7, ECO1, AT4G31400) /Esco2 increase sensitivity to DNA-damaging agents Saccharomyces cerevisiae; Mus musculus; Homo sapiens
TUNEL assay in (MAIL1, AT2G25010) mutant found high number of TUNEL-positive nuclei in mutant but not in wild-type
UV-B light (280–320nm) causes damage to biomolecules such as DNA
HMGA1 and HMGA2 positively regulating (ATATM, ATM, ATM-1, PIG1, AT3G48190) expression occurs via positive feedback loop in response to DNA damage
mammalian (HMGA, AT1G14900) overexpression sensitizes cancer cell lines to methyl-methanesulfonate Homo sapiens
higher expression of histones, ubiquitin-related genes, and DNA-binding proteins in BQC is consequence of indirect effect of damaged DNA caused by UV-B radiation Quercus suber
MCM and (AGD10, MEE28, RPA, AT2G35210) proteins have been shown to play roles in triggering DNA damage repair mechanisms in response to stalled replication forks
(ATATR, ATR, ATR-2, ATRAD3, AT5G40820) responds to replication fork stall
partial depletion of H2A.X.3 and H2A.X.5 by artificial miRNA resulted in weak sensitivity to DNA damage Arabidopsis thaliana
all three histone variants (H2A.X.3, H2A.X.5, (h2a.w.7, HTA7, AT5G27670) ) act within the same genetic pathway Arabidopsis thaliana
γH2A.X foci decorate sites of double-strand breaks (DSBs) Arabidopsis thaliana; metazoa
DNA damage leads to degradation of CDKB2 Arabidopsis thaliana
profuse production of root hairs in X-ray-irradiated B2RNAi-7 plants is typical morphological phenotypic response to DNA damage in roots
UV-B photodimers can activate DNA damage response pathways
regulating cell cycle progress might be protective mechanism to prevent cells with damaged DNA from dividing
GH1-HMGA1 mutants have higher sensitivity to mitomycin C Arabidopsis thaliana
absence of GH1-HMGA1 led to genomic instability Arabidopsis thaliana
UV light exposure causes genotoxic stress
(SMR5, AT1G07500) and (SMR7, AT3G27630) expression is induced under various DNA-damaging conditions Arabidopsis thaliana
53BP1 contains BRCT domain
CRISPR-Kill relies on induction of multiple double-strand breaks (DSBs)
root cells exhibit substantial variability in sensitivity to DSBs induced by zeocin Arabidopsis thaliana
(APP, PARP2, PP, AT4G02390) is upregulated in m56-1fas2-4 mutant Arabidopsis thaliana
bleomycin treatment induced γ-H2A.X elevation Arabidopsis thaliana
root and shoot SCN may have distinct protection to DNA damage Arabidopsis thaliana
(ATXRCC3, XRCC3, AT5G57450) mutant showed greater sensitivity to bleomycin (BLM) Oryza sativa
RAD51A1 and RAD51A2 have no effect on the protein loading of (ATRAD51C, RAD51C, AT2G45280) and (ATXRCC3, XRCC3, AT5G57450) Oryza sativa
(ARLIM15, ATDMC1, DMC1, AT3G22880) cannot load at irradiation-induced double-strand breaks (DSBs) in rice mitotic nuclei Oryza sativa
SUPPRESSOR OF GAMMA RESPONSE 1 (ANAC008, SOG1, AT1G25580) binds to the promoters of B1-type cyclin (CYC1, CYCB1, CYCB1;1, AT4G37490) Arabidopsis thaliana
high concentration of Boron (B) induces DNA double-stranded breaks
cadmium induces genome instability
Col-0 and (AtTK1b, TK1b, TK2, AT5G23070) mutant seedlings challenged with ciprofloxacin in the absence/presence of sucrose, glucose or fructose tested effects of sugars in response to genotoxic agents Arabidopsis thaliana
(AtTK1a, TK1, TK1a, AT3G07800) promoter induction by HU or Zeocin™ is consistent with hypersensitivity shown by (AtTK1a, TK1, TK1a, AT3G07800) mutants to these genotoxins Arabidopsis thaliana
(ATRAD51, RAD51, AT5G20850) plays key role in DNA damage response
m56-1fas2-4 mutant root tip showed clearly detectable immunostaining signals of γ-H2A.X Arabidopsis thaliana
DSBs induced by I- Sce I nuclease only a portion was repaired by synthesis-dependent strand annealing (SDSA) Oryza sativa
(ATRAD51, RAD51, AT5G20850) paralogs have been shown to function in homologous recombination (HR)
(ATRAD51, RAD51, AT5G20850) and (ARLIM15, ATDMC1, DMC1, AT3G22880) are two Escherichia coli RecA homologs found in yeast, mice, and humans
SUPPRESSOR OF GAMMA RESPONSE 1 (ANAC008, SOG1, AT1G25580) upregulates expression of (SMR7, AT3G27630) Arabidopsis thaliana
(anac103, NAC103, AT5G64060) mutants suppress root growth inhibition Arabidopsis thaliana
quantitative shotgun phosphoproteomics provided high-throughput analysis of the DNA damage response network in callus cells
(AtTK1a, TK1, TK1a, AT3G07800) and (AtTK1b, TK1b, TK2, AT5G23070) are required for appropriate response to different kinds of genotoxic stress Arabidopsis thaliana
diRNA production is dependent on (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) (Ataxia Telangiectasia and Rad3-related) Arabidopsis thaliana
(ATNBS1, NBS1, AT3G02680) plays key role in DNA damage response
predominant localization of γH2A.W.7 in heterochromatin and γH2A.X in euchromatin affects dynamics of dephosphorylation and turnover in DNA damage response (DDR) Arabidopsis thaliana
functional conservation of H2A.X is shown in Arabidopsis Arabidopsis thaliana
(h2a.w.7, HTA7, AT5G27670) histone variant plays a role similar to KAP1 and HP1 phosphorylation in mammals Arabidopsis thaliana
γH2A.W.7 foci associated with chromocenters after 2-hr bleomycin treatment represent 13.8% of total γH2A.W.7 foci Arabidopsis thaliana
(h2a.w.7, HTA7, AT5G27670) phosphorylation is phosphorylated with slower dynamics than H2A.X phosphorylation Arabidopsis thaliana
histone variants combining the properties of H2A.X and H2A.W in plants facilitate heterochromatin accessibility during DNA damage response (DDR) plants
DNA damage responses are mediated by highly conserved (ATATM, ATM, ATM-1, PIG1, AT3G48190) and (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) protein kinases
γH2A.X levels in (h2a.w.7, HTA7, AT5G27670) mutant decreased with slower dynamics than in WT Arabidopsis thaliana
photodimer formation is specific to UV-B light Arabidopsis thaliana
role of H2A.X in response to DNA damage is conserved in Arabidopsis Arabidopsis thaliana
overall patterns of (h2a.w.7, HTA7, AT5G27670) and H2A.X did not change upon DNA damage induction Arabidopsis thaliana
h2a.x mutants showed same dynamics of γH2A.W.7 foci as in WT Arabidopsis thaliana
proportion of γH2A.X foci associated with chromocenters in (h2a.w.7, HTA7, AT5G27670) mutant increased significantly compared to WT Arabidopsis thaliana
significant increase of γH2A.X foci within the chromocenters in (h2a.w.7, HTA7, AT5G27670) mutant correlates with slower dynamics of γH2A.X dephosphorylation Arabidopsis thaliana
Oryza sativa may enhance DNA repair capacity upon genotoxic stress Oryza sativa
OsRAD51A2 transcription is increased by 5 Gy X-ray irradiation
DSBs are required for normal localization of (AtRFC1, RFC1, AT5G22010) to meiotic chromosomes Arabidopsis thaliana
(ATATM, ATM, ATM-1, PIG1, AT3G48190) /ATR-dependent DNA damage response activation presumably leads to halt of endoreduplication Arabidopsis thaliana
homologous recombination (HR) is initiated by DNA double-strand breaks (DSBs)
γ-irradiation induces double-strand breaks Arabidopsis thaliana
versatile approach will contribute to improving studies of DNA damage in plants Arabidopsis thaliana
levels of γH2A.X were not altered in (h2a.w.7, HTA7, AT5G27670) mutants compared to WT Arabidopsis thaliana
SQ phosphorylation in (h2a.w.7, HTA7, AT5G27670) may antagonize chromatin condensation Arabidopsis thaliana
role of (h2a.w.7, HTA7, AT5G27670) in DNA damage response (DDR) in Arabidopsis is parallel to role of heterochromatic proteins HP1 and KAP1 in mammals Arabidopsis thaliana; mammals
CDKB2 functions differently in Arabidopsis thaliana and Oryza sativa Arabidopsis thaliana; Oryza sativa
DNA damage neither induces endoreduplication Oryza sativa
transcription of RAD51A2 is enhanced by DNA damage
bleomycin-treated calli support conclusion that endoreduplication is not a major DNA damage response in rice
phosphorylated H2AX (γH2AX) may be regarded as marker to detect double-strand breaks (DSBs) Arabidopsis thaliana
(ATATR, ATR, ATR-2, ATRAD3, AT5G40820) mutants are hypersensitive to replication-blocking agents Arabidopsis thaliana
histone variant H2A.X phosphorylation results in γ-H2A.X Arabidopsis thaliana
γ-H2AX focus formation in (ATRAD51, RAD51, AT5G20850) paralog mutants showed no significant decrease compared with (ATXRCC3, XRCC3, AT5G57450) wild-type Oryza sativa
(ATXRCC3, XRCC3, AT5G57450) immune signals are dramatically reduced following wortmannin treatment Oryza sativa
SUPPRESSOR OF GAMMA RESPONSE 1 (ANAC008, SOG1, AT1G25580) plays a crucial role in DNA damage response as tumor suppressor protein p53
CHK1 phosphorylates tumor suppressor protein p53
(anac103, NAC103, AT5G64060) knockout (KO) lines showed significantly less sensitive root cell death phenotype Arabidopsis thaliana
NAC103-GFP overexpressing (NAC103-OE) lines showed commonly and significantly enhanced transcription levels of (ATBRCA1, BRCA1, AT4G21070) Arabidopsis thaliana
NAC103-OE-in-sog1-1 lines demonstrated partial, but significant, complemented expression of (ATBRCA1, BRCA1, AT4G21070) Arabidopsis thaliana
Overexpression of (anac103, NAC103, AT5G64060) in WT significantly increased zeocin-induced true leaf inhibition Arabidopsis thaliana
ATM-dependent protein phosphorylation establishes functional significance of plant DNA damage response Arabidopsis thaliana
(ATRBR1, RB, RB1, RBR, RBR1, AT3G12280) localized to γ-H2AX foci Arabidopsis thaliana
MIM396 transgenic plants accumulated lower CPDs after UV-B treatment compared with WT and E2FcRNAi plants Arabidopsis thaliana
GUS activity driven by the (AtTK1b, TK1b, TK2, AT5G23070) promoter remained unchanged with all treatments tested Arabidopsis thaliana
DNA double-strand breaks (DSBs) induce selective cell death in stem cells Arabidopsis thaliana
rfc1–2 mutant exhibits >50 γH2AX foci during leptotene Arabidopsis thaliana
Ddc1 protein requires DSBs for localization to meiotic chromosomes
human (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) binds to UV-damaged DNA Homo sapiens
(ATATR, ATR, ATR-2, ATRAD3, AT5G40820) mutant regulate CYCB1;1 at the transcriptional level in root tips Arabidopsis thaliana
Reducing reactive oxygen species (ROS) protects genomic integrity
(ATATM, ATM, ATM-1, PIG1, AT3G48190) (Ataxia Telangiectasia Mutated) is ATAXIA TELANGIECTASIA MUTATED
reduced expression of AtRad52-2 had sensitivity to Mitomycin C Arabidopsis thaliana
γ-irradiation induces loading of (ATRAD51B, RAD51B, AT2G28560) at DSBs Oryza sativa
DNA-damage-triggered phosphorylation of (ANAC008, SOG1, AT1G25580) is required for efficient binding of (ANAC008, SOG1, AT1G25580) to target sites Arabidopsis thaliana
CTT(N)7AAG motif is crucial for DNA damage-induced expression of (ANAC008, SOG1, AT1G25580) target genes in planta Arabidopsis thaliana
(anac103, NAC103, AT5G64060) expression was less strongly induced by MMS Arabidopsis thaliana
NAC103-GFP overexpressing (NAC103-OE) lines showed commonly and significantly enhanced transcription levels of (RPA1E, AT4G19130) Arabidopsis thaliana
overexpression of (anac103, NAC103, AT5G64060) did not increase the transcription levels of (AT4G22960) Arabidopsis thaliana
NAC103-OE-in-sog1-1 lines demonstrated partial, but significant, complemented expression of (AT4G22960) Arabidopsis thaliana
Overexpression of (anac103, NAC103, AT5G64060) in WT significantly increased zeocin-induced root growth inhibition Arabidopsis thaliana
(anac103, NAC103, AT5G64060) mutants displayed incomplete, but significant, inhibition in transcriptional induction of (ATBRCA1, BRCA1, AT4G21070) Arabidopsis thaliana
H2AX-silenced lines displayed mild hypersensitivity to bleomycin Arabidopsis thaliana
gamma-irradiated mature Arabidopsis plants were used in phosphoproteomic study Arabidopsis thaliana
(ATATM, ATM, ATM-1, PIG1, AT3G48190) post-translational signalling networks operating in seeds Arabidopsis thaliana
(ATATM, ATM, ATM-1, PIG1, AT3G48190) (ataxia telangiectasia mutated) and (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) ( and (RAD3, AT2G05635) related) are involved in perception of double-strand breaks and single-stranded DNA
(AtTK1a, TK1, TK1a, AT3G07800) and (AtTK1b, TK1b, TK2, AT5G23070) differ by their regulation in response to DNA damage Arabidopsis thaliana
decrease in auxin signaling is one of the causes of stem cell death Arabidopsis thaliana
DNA crosslinks is one of types of DNA damage tested Chlamydomonas reinhardtii
alt1-1 and alt1-2 mutants root growth is affected similarly to (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) mutant after treatment with hydroxurea Arabidopsis thaliana
(h2a.w.7, HTA7, AT5G27670) mutant expressing S135A mutant did not complement sensitivity of (h2a.w.7, HTA7, AT5G27670) to DNA damage Arabidopsis thaliana
ATM-dependent phosphorylation of histone variant (h2a.w.7, HTA7, AT5G27670) is required for DNA damage response (DDR) Arabidopsis thaliana
DNA damage does not down-regulate Oryza sativa CDKB2;1 Oryza sativa
X-ray exposure increases DNA damage
catalytic activities of CDKs play critical role in the DNA damage response
ATAXIA-TELANGIECTASIA MUTATED (ATATM, ATM, ATM-1, PIG1, AT3G48190) is involved in plant response to DNA damage Arabidopsis thaliana
(ATATM, ATM, ATM-1, PIG1, AT3G48190) has a crucial role in H2A.X phosphorylation and DSB repair Arabidopsis thaliana
γ-irradiation induces loading of (ATXRCC3, XRCC3, AT5G57450) at DSBs Oryza sativa
recombination vectors (pSSA.I– Sce I and pSDSA.I– Sce I) contain recombination substrate Oryza sativa
(ATSUS2, SSA, SUS2, AT5G49190) repairs in (ATRAD51D, RAD51D, SSN1, AT1G07745) mutant were greatly compromised (ATRAD51D, RAD51D, SSN1, AT1G07745) mutant Oryza sativa
wortmannin inhibits plant (ATATM, ATM, ATM-1, PIG1, AT3G48190) and/or other upstream PI3K-like kinases involved in the DNA damage response Oryza sativa
(ATRAD51B, RAD51B, AT2G28560) focus formation in (ATXRCC3, XRCC3, AT5G57450) and (ATXRCC2, XRCC2, AT5G64520) mutant plants displayed normally compared with (ATRAD51B, RAD51B, AT2G28560) wild-type Oryza sativa
(ATBRCA1, BRCA1, AT4G21070) was induced by zeocin in wild-type Arabidopsis thaliana
NAC103-GFP overexpressing (NAC103-OE) lines showed commonly and significantly enhanced transcription levels of (AT4G22960) Arabidopsis thaliana
E2FcRNAi plants show similar DNA damage as found in WT plants Arabidopsis thaliana
QDE-2-interacting small RNAs (qiRNAs) are derived from rDNA repeats Neurospora crassa
ATM-mediated DNA damage response is required to trigger death of CSCDs
(h2a.w.7, HTA7, AT5G27670) mutant expressing S135D mutant did not complement sensitivity of (h2a.w.7, HTA7, AT5G27670) to DNA damage Arabidopsis thaliana
improved accessibility to DNA damage response machinery within heterochromatin would explain delayed dynamics of DNA damage response (DDR) in heterochromatin Arabidopsis thaliana; mammals
Orysa;CDKB2;1 accumulates in response to DNA damage Oryza sativa
X-ray sensitivity of B2RNAi plants analyzed effect of CDKB2;1 knockdown on DNA damage response
induction of DSBs up-regulates CDK inhibitors Arabidopsis thaliana
chilling stress can cause DNA strand breaks
(ANAC008, SOG1, AT1G25580) is essential for efficient activation of DNA repair pathways
restriction enzymes with four-base recognition sequences induce greater than two-fold (ATBRCA1, BRCA1, AT4G21070) expression Arabidopsis thaliana
DNA repair is improved in (FAS1, FUGU2, NFB2, AT1G65470) m123-2 Arabidopsis thaliana
DNA repair gene (ATRAD51, RAD51, AT5G20850) was not increased in pp7l-1 and pp7l-3 mutant lines Arabidopsis thaliana
main-2 and pp7l-1 mutants were both able to transcriptionally respond to DNA damage treatment Arabidopsis thaliana
alt1-2 mutant demonstrated substantial reduction in root growth in presence of 1 mM hydroxurea Arabidopsis thaliana
DNA DSBs in Arabidopsis endoreduplicating differentiating cells do not cause cell-cycle arrest at G 1 /S Arabidopsis thaliana
Adachi et al. (2011) demonstrated expression of Arath ;CDKB2;1 was suppressed in response to DSBs at both transcriptional and protein level Arabidopsis thaliana
DDR genes are involved in DNA repair
non-recombinogenic functions in DNA repair are suggested for some HR proteins
GH1-HMGA1 is identified as factor involved in DNA damage repair in Arabidopsis Arabidopsis thaliana
oxidative stress can cause DNA strand breaks
DNA damage detection leads to activation of ATAXIA-TELANGIECTASIA MUTATED (ATATM, ATM, ATM-1, PIG1, AT3G48190)
DNA damage response (DDR)-related genes would be expected to be increased if cell death was due to impaired genome stability Arabidopsis thaliana
typical symptoms of active DNA damage response includes increased expression of DNA repair genes
Cells deficient in any of the (ATRAD51, RAD51, AT5G20850) paralogs show similar phenotype of elevated frequencies of chromosomal instability
(ATRAD51B, RAD51B, AT2G28560) represents the main functionality of single-strand annealing (SSA) recombination repair Oryza sativa
SUPPRESSOR OF GAMMA RESPONSE 1 (ANAC008, SOG1, AT1G25580) is a key transcription factor that governs DNA damage response Arabidopsis thaliana
ATAXIA-TELANGIECTASIA MUTATED (ATATM, ATM, ATM-1, PIG1, AT3G48190) phosphorylates SUPPRESSOR OF GAMMA RESPONSE 1 (ANAC008, SOG1, AT1G25580) Arabidopsis thaliana
(ATBZIP60, BZIP60, AT1G42990) transcription level did not increase after zeocin treatment Arabidopsis thaliana
γ-H2AX potential function in promotion of HR activity in plants Arabidopsis thaliana
(AtTK1a, TK1, TK1a, AT3G07800) is upregulated by genotoxic agents such as mitomycin C and UV-C radiation Arabidopsis thaliana
(AtTK1a, TK1, TK1a, AT3G07800) and RNR subunit genes are direct targets of (ANAC008, SOG1, AT1G25580) Arabidopsis thaliana
diRNAs most likely function downstream of H2AX phosphorylation Arabidopsis thaliana
(AtMYB56, BRAVO, MYB56, AT5G17800) dynamics upon DNA damage suggest involvement in promoting quiescence
(SMR5, AT1G07500) is important for cell-cycle checkpoint activation following DNA damage Arabidopsis thaliana
CRL4 C3D E3 ubiquitin ligases targets for proteasomal degradation damaged DNA sensor (DDB2, AT5G58760) Arabidopsis thaliana
homologous recombination (HR) acts in repair of DNA breaks occurring after environmental stress
γ-ray induced (ATRAD51, RAD51, AT5G20850) focus formation is observed in (ATRAD51B, RAD51B, AT2G28560) (ATRAD51D, RAD51D, SSN1, AT1G07745) and (ATXRCC2, XRCC2, AT5G64520) mutant plants Arabidopsis thaliana
pyrimidine dimers inhibit transcription
ATAXIA-TELANGIECTASIA MUTATED (ATATM, ATM, ATM-1, PIG1, AT3G48190) and /RAD3-RELATED (ATATR, ATR, ATR-2, ATRAD3, AT5G40820) induce cell-cycle arrest
DNA damage response system (DDR) is crucial in addressing DNA double-strand breaks (DSBs)
(ANAC008, SOG1, AT1G25580) hyperphosphorylation is followed by activation of several (ANAC008, SOG1, AT1G25580) target genes Arabidopsis thaliana
(ANAC008, SOG1, AT1G25580) phosphorylation mutants demonstrate that hyperphosphorylation sites remain unchanged over time Arabidopsis thaliana
(AtPRD1, MEI1, PRD1, AT4G14180) is homolog of human HsTOPBP1
meristematic cells exhibit increasing trend of (ATRAD51, RAD51, AT5G20850) mRNAs Arabidopsis thaliana
DNA damage increases transcriptional output per cell
DDR via HR is associated with S and G2 phases of the cell cycle
(ATRAD54, CHR25, RAD54, AT3G19210) foci emerge with high frequency in G1 and G2 cells Arabidopsis
SOS response is turned on by DNA damage Escherichia coli
ddrm2-2 (ATRAD51, RAD51, AT5G20850) double mutant is more sensitive to (ACPT, AtcPT3, CPT, cPT3, AT2G23410) (camptothecin)
cell cycle arrest is integral part of DNA damage response
stele cells show distinct RAD51 transcriptional response compared to other root cell types (Epidermis, Cortex, Endodermis) Arabidopsis thaliana
faster proliferation rates correlate with increased susceptibility to DNA damage
zeocin promotes arrest at G2/M checkpoint
(CYC1, CYCB1, CYCB1;1, AT4G37490) responds to DNA damage Arabidopsis thaliana
(ANAC008, SOG1, AT1G25580) (Suppressor of Gamma Response1) plays a central role in transcriptional regulation of DNA repair genes Arabidopsis thaliana
(PARP1, AT2G31320) contains BRCT domain
(ATRAD51, RAD51, AT5G20850) transcriptional response shows consistent variations among distinct cell types and developmental zones Arabidopsis thaliana
variations in abundance of cis-regulators may explain varying (ATRAD51, RAD51, AT5G20850) mRNA transcriptional output
ddrm2-2 (ATRAD51, RAD51, AT5G20850) double mutant is more sensitive to CPT than ddrm2-2 and (ATRAD51, RAD51, AT5G20850) single mutants Arabidopsis thaliana
cells in the root tips of X-ray-irradiated B2RNAi-7 mutant were swollen and disorganized
(ATATM, ATM, ATM-1, PIG1, AT3G48190) mutant is hypersensitive to double-strand break (DSB)-inducing reagents Arabidopsis thaliana
increasing zeocin concentrations increases number of DSBs per cell Arabidopsis thaliana
study results shed light on DNA damage response in plants
H2A.X phosphorylation in (FAS1, FUGU2, NFB2, AT1G65470) m123-2 was not affected in (FAS1, FUGU2, NFB2, AT1G65470) m123-2 Arabidopsis thaliana
cell cycle arrest ensures integrity of genetic material
G2/M reporter expression potentially corresponds to checkpoint arrest Arabidopsis thaliana
hydroxyurea (HU) treatment activates G2/M cell cycle arrest
study results uncover distinctions in transcriptional response of (ATRAD51, RAD51, AT5G20850) across cell types
DDRM2 expression induction by DSBs is SOG1-dependent manner Arabidopsis thaliana
DDRM2 is a target gene of (ANAC008, SOG1, AT1G25580) (Suppressor of Gamma Response1) Arabidopsis thaliana
BRAD1 contains BRCT domain
Arabidopsis thaliana lacks homolog of MDC1 Arabidopsis thaliana